Cancer cell membrane-coated mesoporous silica loaded with superparamagnetic ferroferric oxide and Paclitaxel for the combination of Chemo/Magnetocaloric therapy on MDA-MB-231 cells

Cai, Defu; Liu, Likun; Han, Chun; Ma, Xiaoxing; Qian, Jiayi; Zhou, Jianwen; Zhu, Wenquan

doi:10.1038/s41598-019-51029-8

Cited by 62 publications

(48 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A number of novel nanocarriers have emerged ( Table 1 ), e.g., liposomes [ 62 , 63 ], gold nanoparticles [ 64 ], mesoporous silica nanoparticles [ 65 , 66 ], iron oxide nanoparticles[ 67 , 68 ], black phosphorous [ 69 , 70 , 71 ], PLGA nanoparticles [ 58 , 72 ], and layered double hydroxide [ 73 ]. These nanocarriers can either act as drug delivery platforms or as active components in themselves due to their intrinsic physical and chemical properties.…”

Section: Cell Membrane Coated Nanoparticle and Its Applications In Cvdsmentioning

confidence: 99%

Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Zhu

et al. 2021

Molecules

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.

show abstract

Section: Cell Membrane Coated Nanoparticle and Its Applications In Cvdsmentioning

confidence: 99%

Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Zhu

et al. 2021

Molecules

View full text Add to dashboard Cite

show abstract

“…Iron nanomaterials are used as magnetic therapeutics in many MSN-based synergistic systems due to their strong response to AMFs (Zhu and Tao, 2015 ; Guisasola et al, 2018 ). Cai et al ( 2019 ) successfully synthesized CSiFePNs (220 nm) by loading superparamagnetic ferroferric oxide and paclitaxel (PTX) into MSNs coated with MDA-MB-231 cell membranes. The combination system showed the highest anticancer ability (IC 50 value of 0.8 μgL −1 ) compared to CSiFeNs with AMF (IC 50 value of 3.6 μgL −1 ) or CSiFePNs without AMF (>0.8 μgL −1 ), further demonstrating that the combination of magnetotherapy and chemotherapy possesses great potential for the treatment of carcinomas.…”

Section: Chemotherapy and Magnetic Hyperthermia Therapymentioning

confidence: 99%

A Review of Mesoporous Silica Nanoparticle Delivery Systems in Chemo-Based Combination Cancer Therapies

Gao

Shen

et al. 2020

Front. Chem.

View full text Add to dashboard Cite

Chemotherapy is an important anti-tumor treatment in clinic to date, however, the effectiveness of traditional chemotherapy is limited by its poor selectivity, high systemic toxicity, and multidrug resistance. In recent years, mesoporous silica nanoparticles (MSNs) have become exciting drug delivery systems (DDS) due to their unique advantages, such as easy large-scale production, adjustable uniform pore size, large surface area and pore volumes. While mesoporous silica-based DDS can improve chemotherapy to a certain extent, when used in combination with other cancer therapies MSN based chemotherapy exhibits a synergistic effect, greatly improving therapeutic outcomes. In this review, we discuss the applications of MSN DDS for a diverse range of chemotherapeutic combination anti-tumor therapies, including phototherapy, gene therapy, immunotherapy and other less common modalities. Furthermore, we focus on the characteristics of each nanomaterial and the synergistic advantages of the combination therapies. Lastly, we examine the challenges and future prospects of MSN based chemotherapeutic combination therapies.

show abstract

“…Taken together, upon application of an AM field, SPIONs encapsulated in MSN can increase the local temperature up to a certain point, to change the conformation of the temperature responsive gatekeepers and open the pore entrances to release the anti-cancer drugs efficiently without having any premature leakage. There are several reports showing the controlled release of anti-cancer therapeutics by applying a magnetic stimulus [ 180 , 184 , 185 ]. Moreover, there are a few FDA-approved SPIONs for using as imaging agents and EU-approved iron oxide nanoparticles to use in glioblastoma therapy; these can be further exploited in magnetic responsive drug delivery [ 20 ].…”

Section: Stimuli-responsive Drug Delivery Using Msnmentioning

confidence: 99%

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Barui

Cauda

2020

Pharmaceutics

View full text Add to dashboard Cite

The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

show abstract

Cancer cell membrane-coated mesoporous silica loaded with superparamagnetic ferroferric oxide and Paclitaxel for the combination of Chemo/Magnetocaloric therapy on MDA-MB-231 cells

Cited by 62 publications

References 50 publications

Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

A Review of Mesoporous Silica Nanoparticle Delivery Systems in Chemo-Based Combination Cancer Therapies

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Contact Info

Product

Resources

About