Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

Zhang, Jingwei; Yu, Miao; Ni, Weifeng; Xiao, Haijun; Zhang, Jieyuan

doi:10.1080/21691401.2019.1622554

Cited by 58 publications

(28 citation statements)

References 44 publications

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“…Though the surgery, chemotherapy, and targeted drugs offer symptomatic relief and modest improvement in survival for OS patients, the overall survival rate remains unfavourable . It is widely believed that further research on the underlying mechanisms of OS and the search for novel therapeutic targets are highly desirable to improve the prognosis of OS patients .…”

Section: Discussionmentioning

confidence: 99%

Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR‐382‐5p/YB‐1 axis

Wang

et al. 2019

Cell Biochemistry & Function

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Circular RNA (circRNA) can modulate the gene expression via sponging microRNA (miRNA) in multiple malignancies. Nevertheless, the detailed function of circ_0001658 in osteosarcoma (OS) and its regulatory mechanism remain elusive.Real-time PCR was carried out to detect the expressions of circ_0001658, miR-382-5p, and Y box-binding protein 1 (YB-1) mRNA in OS tissues. Besides, western blot was done to monitor YB-1 expression in OS cells. Chi-squared test was used to analyse the correlation between circ_0001658 and clinicopathologic characteristics of OS patients. CCK8 assay, colony formation assay, flow cytometry, and transwell assay were performed to determine the function of circ_0001658. Moreover, dualluciferase reporter gene assay was done to verify the targeting relationship between circ_0001658 and miR-382-5p. Compared with adjacent tissues, circ_0001658 displayed a significantly higher expression in OS tissues. Circ_0001658 could facilitate the proliferation, migration, and invasion of OS cells and impede apoptosis by sponging miR-382-5p. Further, circ_0001658 was proved to directly and negatively regulate the expression of miR-382-5 while positively modulate the expression of YB-1. Circ_0001658 promotes the proliferation and metastasis of OS cells via modulating miR-382-5p/YB-1 axis. Significance of the study:In recent years, the expression and function of circular RNA in cancer have been the focus of tumour research. The study on circular RNA helps elucidate the molecular pathology of tumorigenesis and cancer progression.This study demonstrated that circ_0001658 promotes the proliferation and metastasis of OS cells via modulating miR-382-5p/YB-1 axis. To our best knowledge, this work is the first to study the expression and function of circ_0001658 in cancer. K E Y W O R D Scirc_0001658, miR-382-5p, osteosarcoma, YB-1 | INTRODUCTIONOsteosarcoma (OS) is a common primary malignant bone tumour among children and adolescents, frequently diagnosed in the distal femur, the proximal tibia, and the proximal humerus. 1,2 Though multiple treatments offer symptomatic relief and modest improvement in survival for OS patients, the long-term disease-free survival rate of patients remains unfavourable, only 60% to 75%. 3,4 To make matters worse, the 5-year survival rate was only 27% to 55% in patients with local relapsing and distant metastasis treated by the available therapy clinically. 5 Hence, it is imperative to probe into the detailed mechanism of OS.Circular RNA (circRNA) is a novel class of endogenous noncoding RNA, which exists widely and stably in mammalian cells without the function of encoding proteins. 6,7 Circ-RNA, unlike linear RNAs, features a closed-loop structure. 8 This distinctive structure contributes

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Section: Discussionmentioning

confidence: 99%

Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR‐382‐5p/YB‐1 axis

Wang

et al. 2019

Cell Biochemistry & Function

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“…To date, a number of technologies for cancer treatments have been developed including chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy (PTT), and combination therapy. Among these options, PTT has great potential for effectively treating cancers because of its noninvasive procedure, low toxicity to normal tissues, and high tumour ablation efficiency [1][2][3][4][5][6][7]. Photothermal therapeutic agents that exhibit strong absorbance in the near-infra-red (NIR) region can convert light energy into heat energy to induce hyperthermia (>48 C) and kill tumour cells [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Near-infra-red fluorescent chitosan oligosaccharide lactate for targeted cancer imaging and photothermal therapy

Lee

Jung

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Photothermal therapy (PTT) is a promising approach for effective cancer treatment because of its noninvasive procedure, low toxicity to normal tissues, and high tumour ablation efficiency. Developing a PTT agent with precise tumour imaging capabilities is an essential prerequisite for effective PTT. In this study, we developed a bifunctional near-infra-red (NIR) fluorescent conjugate consisting of chitosan oligosaccharide lactate (COL) and the ZW800-1 NIR fluorophore (COL-ZW). We demonstrate that this conjugate is easy to use and that it is an effective theranostic agent for fluorescence-guided photothermal treatment. The temperature of COL-ZW increased by 62.3 C after NIR laser irradiation (1.1 W/cm 2) for 5 min in HT-29 tumour-bearing mice. The HT-29 tumours targeted by COL-ZW showed a remarkable decrease in tumour volume until a week after photothermal treatment. These in vivo results demonstrate that the bifunctional COL-ZW generates strong fluorescence and light-triggered PTT in tumour sites, indicating successful fluorescence-guided PTT. Importantly, no tumour recurrence or treatmentinduced toxicity was observed after a single dose of COL-ZW with laser irradiation. Therefore, a combinatorial treatment with COL-ZW and NIR laser irradiation could serve as a promising strategy for photothermal cancer therapy.

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“…In the study by Zhang et al, the silica nanoparticle loaded with photosensitive ICG and coated with osteosarcoma cancer cells showed the better performance of the formulation in both in vivo and in vitro experiments. [81] In a similar study, a silica nanoparticle loaded with photosensitive Chlorins e6 was also observed to show high efficacy in targeting and treatment against gastric cancer both in vivo and in vitro. [82] Combination therapies have always fared better in clinical trials because it helps to control different aspects of the innately complex cancer-ridden body.…”

Section: Photodynamic Therapy Combined With Chemo/immunotherapymentioning

confidence: 86%

Cancer Cell Membrane Technology for Cancer Therapy

et al. 2020

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Even after decades of research, one of the most significant challenges in nanotechnology-based cancer therapy is to increase the target specificity and to reduce the side effects. As a result, even after substantial progress in lab-scale research, clinical trials have mostly failed. One of the emerging new strategies to increase the target specificity and to increase the chemotherapeutic efficacy is to mimic biological moieties using cellular membranes. Owing to its preferential accumulation at the tumor site, cancer cell membrane presents itself as a promising surface functionalization to the nanocarriers. This review aims to summarize recent reports on the cancer cell membrane and the hybrid membrane-associated research for the comprehensive understanding of their successful implementation in cancer therapy.

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Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

Cited by 58 publications

References 44 publications

Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR‐382‐5p/YB‐1 axis

Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR‐382‐5p/YB‐1 axis

Near-infra-red fluorescent chitosan oligosaccharide lactate for targeted cancer imaging and photothermal therapy

Cancer Cell Membrane Technology for Cancer Therapy

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