2022
DOI: 10.1038/s41368-022-00192-2
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Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN

Abstract: Tumor volume increases continuously in the advanced stage, and aside from the self-renewal of tumor cells, whether the oncogenic transformation of surrounding normal cells is involved in this process is currently unclear. Here, we show that oral squamous cell carcinoma (OSCC)-derived small extracellular vesicles (sEVs) promote the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of normal epithelial cells but delay their apoptosis. In addition, nuclear-cytoplasmic invaginations a… Show more

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Cited by 4 publications
(2 citation statements)
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“…Serial freezing section of FAO and v-FAO was processed as we recently described 44 , 49 . The freezing section at the core of FAO/v-FAO was employed to analysis the cell composite and protein expression.…”
Section: Methodsmentioning
confidence: 99%
“…Serial freezing section of FAO and v-FAO was processed as we recently described 44 , 49 . The freezing section at the core of FAO/v-FAO was employed to analysis the cell composite and protein expression.…”
Section: Methodsmentioning
confidence: 99%
“…У той же час наявнiсть змiн, пов'язаних зi злоякiсним новоутворенням, у нормальних клiтинах стала загальновiдомим фактом [19,40]. Морфологiчний аналiз нормальних клiтин у хворих на рак зазвичай виконується поблизу пухлини, враховуючи, що раковi клiтини безпосередньо впливають на сусiднi тканини [22,32]). Однак нормальнi клiтини, розташованi далеко вiд пухлини, такi як клiтини букального епiтелiю, також реагують на наявнiсть пухлини в органiзмi [37,39].…”
Section: приклад застосування альтернативних постулатIвunclassified