Cancer Chemoprevention by Ginseng in Mouse Liver and Other Organs

Abstract

Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.

Therapeutic Effects of Korean Red Ginseng Extract in Egyptian Patients with Chronic Liver Diseases

“…They concluded that Rg3 + Rg5 had anticarcinogenic effects. Similar to the current observations, Nishino et al [70] reported that oral administration of red ginseng extracts significantly suppressed spontaneous liver tumour formation in C3H/He male mice.…”

Ochratoxin A Toxic Effect on Rat Kidneys and the Potential Protective Effect of Ginseng: Histopathologic, Histochemical, and Image Analysis Morphometric Studies

“…The injection of rats with ginseng only, led to a significant increase in DNA content in kidney cells. These effects may be due to the antioxidant nature of ginseng [33].…”

“…Nishino et al [33] reported that ginseng can increase body resistance to many harmful factors and protect tissue from damage and could inhibit lipid peroxidation of rat liver and kidney. Lee et al [34] stated that ginseng may reduce cell damage induced by toxic substance and acts to stabilize cell membranes there by providing protection against toxic agents induced tissue injury.…”

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“…Interestingly, oral administration of a white ginseng-containing Chinese medicinal prescription known as ren-shen-yang rong-tang, resulted in the suppression of skin tumor promotion by 12-otetradecanoylphorbol-13 acetate in 7, 12-dimethylbenz[a] anthraceneinitiated CD-1 mice, suggesting the usefulness of ginseng in the field of cancer prevention 46 . Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts that has significantly inhibited, in a doseand time dependent manner, the proliferation of cancer cells in the A549 human lung cancer cell line.…”