Cancer chemoprotective effects of Curcuma xanthorrhiza

Abstract

Curcuma xanthorrhiza Roxb. (Zingiberaceae) is a medicinal plant widely spread in South East Asia. In particular, it is commonly used not only for food and medicinal purposes in Indonesia, but also for the topical treatment of acne and skin inflammations as Thai traditional medicine. It was found that the methanol extract of C. xanthorrhiza inhibited significantly 7,12-dimethylbenz[a]anthracene (DMBA)-induced bacterial mutagenesis of Salmonella typhimurium TA98 and TA100 in the presence of S9, and the mutagenesis induced by H2O2 and tert-butylhydroperoxide in S. typhimurium TA102, respectively. In addition, 12-O-tetradecanolyphorbol-13-acetate(TPA)-induced mouse ear edema was markedly inhibited by pretreatment with C. xanthorrhiza extract. C. xanthorrhiza extract dose-dependently reduced ODC expression in mouse skin with TPA-induced acute inflammation. Furthermore, repeated treatment with 0.1% C. xanthorrhiza extract reduced the average number of tumors per mouse and the percentage of tumor-bearing mice in a multistage mouse skin carcinogenesis induced by DMBA and TPA. These results demonstrate that the methanol extract of C. xanthorrhiza possesses cancer chemopreventive potential.

Optimizing oil and xanthorrhizol extraction from Curcuma xanthorrhiza Roxb. rhizome by supercritical carbon dioxide

“…It has been used to treat stomach diseases, liver disorders, constipation, bloody diarrhoea, dysentery, children's fevers, hypotriglyceridaemic, haemorrhoids and skin eruptions due to its antibacterial, antioxidative, antitumor, anti-inflammatory and hepatoprotective effects (Hwang et al 2000;Lin et al 1996;Masuda et al 1992;Park et al 2008;Ruslay et al 2007;Yasni et al 1994). The traditional benefits of Curcuma xanthorrhiza were further supported by isolation and identification of several active constituents, including xanthorrhizol, curcumin and few volatile substances.…”

Acetylcholinesterase inhibitors and compounds promoting SIRT1 expression from Curcuma xanthorrhiza

“…Curcuma xanthorrhiza Roxb., commonly known as temu lawak or Javanese turmeric in Indonesia, is a well-known traditional medicinal plant with its anti-inflammatory (Ozaki, 1990) and anticancer (Park et al, 2008) activities as well as protective effects against liver damage (Lin et al, 1995). Terpenoids and curcuminoids were reported as its most abundant compounds (Uehara et al, 1992;Sukari et al, 2008).…”

Therapeutic Effect of Supercritical CO2 Extracts of Curcuma Species with Cancer Drugs in Rhabdomyosarcoma Cell Lines

“…Similarly, anticancer properties of C . xanthorrhiza and its active ingredient xanthorrhizol have been described by several investigators (Park et al ., ; Cheah et al ., ; Choi et al ., ; Kang et al ., ; Tee et al ., ). However, a systematic comparison of cytotoxic activity of supercritical CO 2 extracts of Curcuma species and their combination effects with anticancer drugs have not been pursued to date.…”