Cancer chemotherapy: new strategies for success.

Berger, Nathan A.

doi:10.1172/jci112692

Cited by 21 publications

(9 citation statements)

References 66 publications

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“…Recently, researchers have attempted to regulate autophagy and prevent further tumor progress . Compared to present cancer therapy strategies, such as chemo‐, immuno‐, gene, radiation, photothermal, and photodynamic therapies, the autophagy‐based conceptual pilot studies for cancer therapy are of particular – and growing – interest in autophagy‐deficient cancers, for example, breast, ovarian, and prostate cancers …”

Section: Methodsmentioning

confidence: 99%

Self‐Assembled Autophagy‐Inducing Polymeric Nanoparticles for Breast Cancer Interference In‐Vivo

et al. 2015

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A peptide-conjugated poly(β-amino ester) that self-assembles into micelle-like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer-beclin-1 (P-Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small-molecule drugs: poor delivery to tumors owing to enzymatic degradation, and unstable, non-specific bio-distribution and targeting in the tumor tissues.

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Section: Methodsmentioning

confidence: 99%

Self‐Assembled Autophagy‐Inducing Polymeric Nanoparticles for Breast Cancer Interference In‐Vivo

et al. 2015

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“…The current choice of treatment for this disorder is chemotherapy, which has been proven to be effective in treatment of all types of cancer. [1] In current anticancer therapy, the drugs are administered using intravenous route or oral route using conventional formulations. Episodes of acute and delayed emesis are common in patients receiving chemotherapy and this affects the quality of life of cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Oral buccoadhesive films of ondansetron: Development and evaluation

Kumria

Gupta

Bansal

et al. 2013

Int J Pharma Investig

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Introduction:Difficulty or inability in swallowing tablets/capsules during or after chemotherapy is common due to chemotherapy induced nausea and vomiting in patients. Buccoadhesive films of ondansetron hydrochloride were prepared for the prevention and treatment of chemotherapy-induced emesis. Films of varying polymeric composition were prepared in order to facilitate initial as well as prolonged drug release that could take care of acute as well as delayed emesis.Materials and Methods:Mucoadhesive films were prepared using polymers such as hydroxypropyl methylcellulose (HPMC) E5, HPMC K100, and Eudragit® NE 30 D. The effect of concentration of these polymers on physical properties and drug release were studied. All the films were prepared by solvent casting method. In another part of the study, the effect of drug concentration on physical and mucoadhesive properties of film were assessed, keeping the polymer concentration fixed.Results:Films containing HPMC showed good mucoadhesion. Increasing the concentration of Eudragit® NE 30 D in the films retarded drug release and increased residence time, however, reduced mucoadhesion. At a fixed polymer concentration and ratio, films prepared using an increased drug content showed an increased mucoadhesion.Conclusion:Films prepared using HPMC E5 (1000 mg), HPMC K100 (500 mg), and Eudragit® NE 30 D (750 mg) provided initial rapid followed by sustained drug release over a period of 6 h. Given the promising results, the study concluded that the developed buccal films have the potential to release ondansetron required for chemotherapy induced acute and delayed emesis.

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“…The first mechanism involves activation of poly(ADP-ribose) polymerase following hydrogen peroxide-induced DNA strand breaks (Schraufstatter et al, 1986). Activation of poly(ADP-ribose)polymerase consumes NAD+, a process that is subsequently associated with a loss of ATP levels (Ueda & Hayaishi, 1985;Berger et al, 1986;Bruchelt et al, 1991). This second mechanism involves hydrogen peroxide inhibition of glycolysis by the inactivation of glyceraldehyde 3-phosphate dehydrogenase resulting in depletion of ATP levels (Brodie & Reed, 1987 Optimisation of this therapeutic approach will require improvements in the delivery and control of the ROS-generating enzyme system and assessment of the pathological consequences.…”

Section: Discussionmentioning

confidence: 99%

Oxidation therapy: the use of a reactive oxygen species-generating enzyme system for tumour treatment

Ben-Yoseph

Ross²

1994

Br J Cancer

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Summary Oxygen radicals induce cytotoxicity via a variety of mechanisms, including DNA damage, lipid peroxidation and protein oxidation. Here, we explore the use of a polyethylene glycol (PEG)-stabilised enzyme capable of producing reactive oxygen species (ROS), glucose oxidase (GO), for the purpose of harnessing the cytotoxic potential of ROS for treating solid tumours. PEG-GO (200 U), administered by two intratumoral injections 3 h apart, produced a significant growth delay in subcutaneous rat 9L gliomas as compared with control animals receiving heat-denatured PEG-GO. Rats were protected from systemic toxicity by subsequent i.v. administration of PEG-superoxide dismutase (PEG-SOD) and PEG-catalase. In vivo tumour metabolic changes, monitored using 31P magnetic resonance spectroscopy (3'P-MRS) 6 h following initial administration of PEG -GO, revealed a 96 ± 2% reduction in the ATP/P, ratio and a 0.72 ± 0.10 unit decline in intracellular pH. A 3-fold sensitisation of 9L glioma cells in vitro to hydrogen peroxide could be achieved by a 24 h preincubation with buthionine sulphoximine (BSO). This study suggests that oxidation therapy, the use of an intratumoral ROS-generating enzyme system for the treatment of solid tumours, is a promising area which warrants further exploration.

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Cancer chemotherapy: new strategies for success.

Cited by 21 publications

References 66 publications

Self‐Assembled Autophagy‐Inducing Polymeric Nanoparticles for Breast Cancer Interference In‐Vivo

Self‐Assembled Autophagy‐Inducing Polymeric Nanoparticles for Breast Cancer Interference In‐Vivo

Oral buccoadhesive films of ondansetron: Development and evaluation

Oxidation therapy: the use of a reactive oxygen species-generating enzyme system for tumour treatment

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