Câncer de mama: efeito prognóstico da resposta patológica completa após quimioterapia neoadjuvante

Vaisberg, Victor Van; Boas, Mariana da Silva Vilas; Stephan, Bruno de Oliveira; Matutino, Adriana Reis Brandão; Lima, Juliana Bezerra Medeiros de; Mano, Max Senna

doi:10.11606/issn.1679-9836.v94isupl.p31-31

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“…Of 213 patients evaluated, conservative surgery was possible in 59.0% of the cases, which corroborates data from the literature, in which NACT has become an alternative to expand the indication of conservative surgery in patients who, initially, are not candidates for the procedure. Axillary emptying was necessary in 89.3% of cases, similar results reported by Van Vaisberg et al 17 , in which 85% of patients were submitted to axillary emptying. Such data can be explained by the higher percentage of advanced stages and, in addition, during the sample collection period, axillary emptying was the choice in the case of clinically compromised armpits (N1+).…”

Section: Discussionsupporting

confidence: 84%

Influence of breast cancer subtype on pathological complete response

et al. 2020

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Objective: To compare the rates of pathological complete response (pCR) after treatment with neoadjuvant chemotherapy, in the different subtypes of breast cancer in patients followed at the Mastology Service of Hospital do Servidor Público Estadual. Methods: Descriptive and retrospective study, in which medical records of 213 patients diagnosed with breast cancer and submitted to neoadjuvant chemotherapy were reviewed, from February 2011 through January 2018. Histological data collected were: hormone receptors, hyperexpression of HER-2, grade, histological type and clinical data: age of the patient at diagnosis, tumor size and clinical stage at diagnosis and after chemotherapy, and rate of pCR. Results: The mean age of patients at diagnosis was 53.97 years. Forty-six patients (21,6%) had pCR, 77 (36.1%) were grade 2 and 136 (63.9%) were grade 3. Regarding cancer subtype, 29 patients (13.6%) were reported to have pure HER2 subtype, 48 patients (22.5%) corresponded to Luminal A subtype, 51 (23.9%) to Luminal B, and 66 patients (31.0%) were characterized as Triple Negative, while only 17 patients (7.9%) had Luminal B HER. Conclusion: The subtypes Pure HER 2 and Luminal B had the highest pCR rates.

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Section: Discussionsupporting

confidence: 84%