Cáncer de próstata: biomarcadores prometedores relacionados con la enfermedad agresiva

Silva, M.N. Ribeiro da; Tobias-Machado, Marcos; Lima-Pompeo, Antonio Carlos; Reis, Leonardo Oliveira; Pinhal, Maria Aparecida da Silva

doi:10.1016/j.acuro.2011.11.017

Cited by 3 publications

(1 citation statement)

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“…In 2017 the recommendation was updated and for men between 55 to 69 years the new recommendation is C, meaning that the decision about whether to be screened for prostate cancer should be an individual one. This discussion has increased the efforts to identify molecules that are expressed in prostate cancer and that can be associated with invasion and metastasis to improve the current prognostic capabilities and management of prostate cancer (1).…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of Chondroitin sulfate, Heparan sulfate and Hyaluronic acid in prostate cancer

et al. 2018

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Purpose: The present study evaluates chondroitin sulfate (CS) and heparan sulfate (HS) in the urine and hyaluronic acid (HA) in the plasma of patients with prostate cancer before and after treatment compared to a control group. Materials and Methods: Plasma samples were used for HA dosage and urine for quantification of CS and HS from forty-four cancer patients and fourteen controls. Clinical, laboratory and radiological information were correlated with glycosaminoglycan quantification by statistical analysis. Results: Serum HA was significantly increased in cancer patients (39.68 ± 30.00 ng/ mL) compared to control group (15.04 ± 7.11 ng/mL; p=0.004) and was further increased in high-risk prostate cancer patients when compared to lower risk patients (p = 0.0214). Also, surgically treated individuals had a significant decrease in seric levels of heparan sulfate after surgical treatment, 31.05 ± 21.01 μg/mL (before surgery) and 23.14 ± 11.1 μg/mL (after surgery; p=0.029). There was no difference in the urinary CS and HS between prostate cancer patients and control group. Urinary CS in cancer patients was 27.32 ± 25.99 μg/mg creatinine while in the men unaffected by cancer it was 31.37 ± 28.37 μg/mg creatinine (p=0.4768). Urinary HS was 39.58 ± 32.81 μg/ mg creatinine and 35.29 ± 28.11 μg/mg creatinine, respectively, in cancer patients and control group (p=0.6252). Conclusions: Serum HA may be a useful biomarker for the diagnosis and prognosis of prostate cancer. However, urinary CS and HS did not altered in the present evaluation. Further studies are necessary to confirm these preliminary findings.

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Section: Introductionmentioning

confidence: 99%