Cáncer de pulmón en la provincia de Ávila. Tasas de incidencia, epidemiología del año 2012 y tendencias en los últimos 20 años

Hernández-Hernández, Jesús; Vega-Herrero, M.B. Moreno de; Iglesias-Heras, M.; García‐García, Rebeca; Hernández-Terciado, F.; Celdrán-Gil, José

doi:10.1016/j.semerg.2014.07.003

Cited by 5 publications

(2 citation statements)

References 24 publications

(20 reference statements)

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“…Lung cancer is one of the most common malignant tumors worldwide, with smoking and other environmental factors considered the main risk factors of the disease ( 1 ). The disease markedly impairs patient health and quality of life ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway

Zhao

et al. 2016

Oncology Letters

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Gefitinib is a selective inhibitor of the tyrosine kinase epidermal growth factor receptor, which inhibits tumor pathogenesis, metastasis and angiogenesis, as well as promoting apoptosis. Therefore, gefitinib presents an effective drug for the targeted therapy of lung cancer. However, the underlying mechanisms by which gefitinib induces lung cancer cell death remain unclear. To investigate the effects of gefitinib on lung cancer cells and the mechanism of such, the present study analyzed the effect of gefitinib on the autophagy, apoptosis and proliferation of the A549 and A549-gefitinib-resistant (GR) cell lines GR. The regulation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/ mammalian target of rapamycin (mTOR) pathway was also investigated. Acridine orange staining revealed that gefitinib induced autophagy of A549 cells but not A549-GR cells. In addition, gefitinib promoted apoptosis and inhibited proliferation of A549 cells but not A549-GR cells. Furthermore, western blot analysis demonstrated that gefitinib treatment led to the downregulation of PI3K, AKT, pAKT, mTOR and phosphorylated-mTOR protein expression in A549 cells but not A549-GR cells. LY294002 blocked the PI3K/AKT/mTOR pathway and induced autophagy and apoptosis of A549 cells, however, no synergistic effect was observed following combined treatment with gefitinib and LY294002. In conclusion, the results of the present study indicate that gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway, which leads to lung cancer cell death.

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Section: Introductionmentioning

confidence: 99%

Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway

Zhao

et al. 2016

Oncology Letters

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show abstract

“…A nivel nacional, según The Global Cancer Observatory, los datos de 2018 indican que el CB fue el tercer cáncer en incidencia tras el carcinoma de mama y próstata, pero el más mortal, con aproximadamente 22.800 fallecimientos. Entre las mujeres españolas fue el cuarto en incidencia y el tercero en mortalidad [17] Es previsible que la mayor edad media de nuestra población condicione un aumento de casos de CB [18]. En contraposición, la disminución del hábito tabáquico que se comenzó a observar en varones en la década de los 80 [19] tenderá a reducir el número de casos, hecho que debiera empezar a apreciarse en breve.…”

Section: Epidemiologíaunclassified

Influencia de la estadificación multidisciplinar mediante ecobroncoscopia-ecoendoscopia en el cáncer de pulmón no microcítico con mediastino radiológicamente normal

Zubizarreta¹

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Trends in lung cancer incidence in Spain (1990–2019): insights from Global Burden of Diseases data

Cayuela,

Gaeta,

Lopez-Campos

et al. 2024

Clin Transl Oncol

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Cáncer de pulmón en la provincia de Ávila. Tasas de incidencia, epidemiología del año 2012 y tendencias en los últimos 20 años

Cited by 5 publications

References 24 publications

Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway

Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway

Influencia de la estadificación multidisciplinar mediante ecobroncoscopia-ecoendoscopia en el cáncer de pulmón no microcítico con mediastino radiológicamente normal

Trends in lung cancer incidence in Spain (1990–2019): insights from Global Burden of Diseases data

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