Cancer depends on fatty acids for ATP production: A possible link between cancer and obesity

Lee, Ho; Woo, Sang Myung; Jang, Hyonchol; Kang, Mingyu; Kim, Soo-Youl

doi:10.1016/j.semcancer.2022.07.005

Cited by 26 publications

(23 citation statements)

References 89 publications

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“…Warburg-like cells are characterized by abnormal mitochondrial activity, which pushes the cells towards aerobic glycolysis [ 47 , 48 ]. As a consequence, these cells have a reduced uptake of the (fatty acid) carrier serum protein albumin together with distinct differences in fatty acid metabolism (compare Figure 5 A) [ 49 ]. Our data further suggest that Warburg-like cells are less capable of coping with cisPt(PhB) 2 , leading to the rapid induction of a non-apoptotic form of cell death.…”

Section: Discussionmentioning

confidence: 99%

Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands

et al. 2023

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For a variety of cancer types, platinum compounds are still among the best treatment options. However, their application is limited by side effects and drug resistance. Consequently, multi-targeted platinum(IV) prodrugs that target specific traits of the malignant tissue are interesting new candidates. Recently, cisPt(PhB)2 was synthesized which, upon reduction in the malignant tissue, releases phenylbutyrate (PhB), a metabolically active fatty acid analog, in addition to cisplatin. In this study, we in-depth investigated the anticancer properties of this new complex in cell culture and in mouse allograft experiments. CisPt(PhB)2 showed a distinctly improved anticancer activity compared to cisplatin as well as to PhB alone and was able to overcome various frequently occurring drug resistance mechanisms. Furthermore, we observed that differences in the cellular fatty acid metabolism and mitochondrial activity distinctly impacted the drug’s mode of action. Subsequent analyses revealed that “Warburg-like” cells, which are characterized by deficient mitochondrial function and fatty acid catabolism, are less capable of coping with cisPt(PhB)2 leading to rapid induction of a non-apoptotic form of cell death. Summarizing, cisPt(PhB)2 is a new orally applicable platinum(IV) prodrug with promising activity especially against cisplatin-resistant cancer cells with “Warburg-like” properties.

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Section: Discussionmentioning

confidence: 99%

Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands

et al. 2023

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“…This indicates that the addition of BC2000 helps fatty acid degradation to provide energy for the body. Elevated levels of fatty acids in the blood are a major factor driving insulin secretion [ 48 ]. Bile acids are the major products of cholesterol metabolism in the liver.…”

Section: Discussionmentioning

confidence: 99%

Weizmannia coagulans BC2000 Plus Ellagic Acid Inhibits High-Fat-Induced Insulin Resistance by Remodeling the Gut Microbiota and Activating the Hepatic Autophagy Pathway in Mice

Jin

Dang

et al. 2022

Nutrients

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(1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; (2) Methods: C57BL/6J mice were divided into five groups (n = 10/group): low-fat-diet group, high-fat-diet group, EA intervention group, EA + W. coagulans BC77 group, and EA + W. coagulans BC2000 group; (3) Result: W. coagulans BC2000 showed a synergistic effect on EA’s lowering insulin resistance index and inhibiting high-fat diet-induced endotoxemia. The combined effect of BC2000 and EA activated the autophagy pathway in the mouse liver, a urolithin-like effect. This was associated with altered β-diversity of gut microbiota and increased Eggerthellaceae, a potential EA-converting family. Ellagic acid treatment alone and the combined use of ellagic acid and W. coagulans BC77 failed to activate the hepatic autophagy pathway; (4) Conclusions: W. coagulans BC2000 can assist EA in its role of preventing insulin resistance. This study provides a basis for the development of EA-rich functional food supplemented with W. coagulans BC2000.

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“…ATP is an essential compound for life, providing energy for most processes in living systems, such as chemical synthesis, dissolution of condensates, transmission of nerve impulses, and muscle contraction [ 63 , 64 , 65 ]. In particular, ATP is significantly elevated in tumor tissues due to its rapid proliferation and metabolism [ 66 ].…”

Section: Strategies For Controlled Drug Releasementioning

confidence: 99%

Recent Advances in Supramolecular-Macrocycle-Based Nanomaterials in Cancer Treatment

Zheng

Zhao

et al. 2023

Molecules

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Cancer is a severe threat to human life. Recently, various therapeutic strategies, such as chemotherapy, photodynamic therapy, and combination therapy have been extensively applied in cancer treatment. However, the clinical benefits of these therapeutics still need improvement. In recent years, supramolecular chemistry based on host–guest interactions has attracted increasing attention in biomedical applications to address these issues. In this review, we present the properties of the major macrocyclic molecules and the stimulus–response strategies used for the controlled release of therapeutic agents. Finally, the applications of supramolecular-macrocycle-based nanomaterials in cancer therapy are reviewed, and the existing challenges and prospects are discussed.

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Cancer depends on fatty acids for ATP production: A possible link between cancer and obesity

Cited by 26 publications

References 89 publications

Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands

Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands

Weizmannia coagulans BC2000 Plus Ellagic Acid Inhibits High-Fat-Induced Insulin Resistance by Remodeling the Gut Microbiota and Activating the Hepatic Autophagy Pathway in Mice

Recent Advances in Supramolecular-Macrocycle-Based Nanomaterials in Cancer Treatment

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