Cancer drug delivery in the nano era: An overview and perspectives

Li, Zhen; Tan, Shirui; Shuan, LI; Shen, Qiang; Wang, Kunhua

doi:10.3892/or.2017.5718

Cited by 340 publications

(243 citation statements)

References 191 publications

(158 reference statements)

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“…A simple synthetic methodology based on the 1,3-dipolar cycloaddition reaction between an alkyne based core and a bromonitrile oxide, followed by esterification for a stitching hydrophilic polyethylene glycol tail to the core, provides a novel route to architectural polymers containing an isoxazole-based dendron. The addition of a polyethylene glycol tail to the telodendrimer confers solubility in a variety of solvents including aqueous medium, as well as steric stability to the telodendrimer structure [51,52]. These architectural polymers are candidate macromolecular agents exerting marked loss of notoriously resistant glioblastoma cells to therapeutic interventions and our results show that U251N glioblastoma cells are almost completely eliminated when exposed to the telodendrimer.…”

Section: Resultsmentioning

confidence: 68%

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

et al. 2020

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An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.

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Section: Resultsmentioning

confidence: 68%

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

et al. 2020

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“…Although a remarkable range of water-insoluble guest molecules have been solubilized by dendrimer-based principles described earlier in Section 3, it is truly amazing how these dendrimer-drug enhancement activities have been applied to so many well-known FDA-approved APIs [127]. In addition to traditional formulation strategies, new parameters are being considered such as dendrimer core types, interior compositions, generation levels, surface chemistries, dendrimer surface PEGylation to produce new dendrimer core:PEG shell architectures to mention a few.…”

Section: The Significant Role Of Dendrimers In the Delivery Of Apismentioning

confidence: 99%

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Tomalia

Nixon²,

Hedstrand³

2020

Biomolecules

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This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster catalysts. Historically, it begins with early unreported work by the Tomalia Group (i.e., The Dow Chemical Co.) revealing that all known dendrimer family types may be divided into two major symmetry categories; namely: Category I: symmetrical branch cell dendrimers (e.g., Tomalia, Vögtle, Newkome-type dendrimers) possessing interior hollowness/porosity and Category II: asymmetrical branch cell dendrimers (e.g., Denkewalter-type) possessing no interior void space. These two branch cell symmetry features were shown to be pivotal in directing internal packing modes; thereby, differentiating key dendrimer properties such as densities, refractive indices and interior porosities. Furthermore, this discovery provided an explanation for unimolecular micelle encapsulation (UME) behavior observed exclusively for Category I, but not for Category II. This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs, engineering dendrimer critical nanoscale design parameters (CNDPs) for optimized properties and concluding with high optimism for the anticipated role of dendrimer-based solubilization principles in emerging new life science, drug delivery and nanomedical applications.

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“…Although CSO-SA/EMO released EMO relatively slowly, the antitumor effect of CSO-SA/EMO does not slow or decline. Many studies have shown nanodrug delivery systems can improve the antitumor activity of chemotherapy drugs [21].…”

Section: Toxicity Of Cso-sa/emo To Gastric Cancer Cellsmentioning

confidence: 99%

Preparation and Evaluation of Novel Emodin-loaded Stearic Acid-g-chitosan Oligosaccharide Nanomicelles

Jiang

et al. 2020

Nanoscale Res Lett

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The purpose of this study was to prepare and characterize emodin-loaded stearic acid-g-chitosan oligosaccharide (CSO-SA/EMO) and to evaluate its antitumor activity in vitro. In this study, stearic acid-g-chitosan oligosaccharide was used as a carrier and its physicochemical properties were determined by different methods. Cell uptake behavior was examined using FITC-labeled stearic acid-g-chitosan oligosaccharide. CSO-SA/EMO was prepared using ultrasonication and dialysis. Particle size, surface potential, entrapment efficiency, and drug release behavior were studied in vitro. The effects of CSO-SA/EMO on gastric cancer cells were investigated using MTT assay and flow cytometry. Results showed CSO-SA/EMO particle size was larger and potential was smaller than that of stearic acid-g-chitosan oligosaccharide. The 12 h micellar uptake by MGC803 and BGC823 cells was sufficient, and the micelles were able to abundantly accumulate at lesion sites in mice thus achieving good passive EPR targeting. MTT and cell cycle arrest assays showed CSO-SA/EMO-enhanced antitumor activity significantly towards MGC803 and BGC823 cells compared with that of free emodine. Tumor volume, hematoxylin and eosin staining, and terminal deoxynucleotide transferase dUTP nick-end labeling assay proved CSO-SA/EMO had a significant antitumor effect on tumor tissues in vivo. In conclusion, the ultrasonication-dialysis method provided a simple and effective method for preparing CSO-SA/EMO. The delivery of emodine using a micelle system improved its antitumor effects effectively.

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Cancer drug delivery in the nano era: An overview and perspectives

Cited by 340 publications

References 191 publications

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Preparation and Evaluation of Novel Emodin-loaded Stearic Acid-g-chitosan Oligosaccharide Nanomicelles

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