Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

Russo, Mariangela; Chen, Mengnuo; Mariella, Elisa; Peng, Haoning; Rehman, Sumaiyah K.; Sancho, Elena; Sogari, Alberto; Toh, Tzen S.; Balaban, Nathalie Q.; Batlle, Eduard; Bernards, Rene; Garnett, Mathew J.; Hangauer, Matthew; Leucci, Eleonora; Marine, Jean-Christophe; O’Brien, Catherine A.; Oren, Yaara; Patton, E. Elizabeth; Robert, Caroline; Rosenberg, Susan M.; Shen, Shensi; Bardelli, Alberto

doi:10.1038/s41568-024-00737-z

Nat Rev Cancer

2024

DOI: 10.1038/s41568-024-00737-z

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Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

Mariangela Russo,

Mengnuo Chen,

Elisa Mariella

et al.

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Cited by 2 publications

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Radiation-induced senescence in glioblastoma: An overview of the mechanisms and eradication strategies

Dehghan,

Mousavikia,

Qasempour

et al. 2024

Life Sciences

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Radiation-induced senescence in glioblastoma: An overview of the mechanisms and eradication strategies

Dehghan,

Mousavikia,

Qasempour

et al. 2024

Life Sciences

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The molecular determinants of phenotypic plasticity in homeostasis and neoplasia

Balk,

Goodrich

2024

CANCER HETEROG PLAST

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Phenotypic plasticity, the capacity of cells to transition between distinct phenotypic and lineage states over time, is a genetically and epigenetically encoded trait essential for normal development and adult tissue homeostasis. In cancer, phenotypic plasticity programs can be deployed aberrantly to enable disease progression and acquired therapeutic resistance. Cancer phenotypic plasticity is a current barrier to achieving cures for advanced cancers using available molecularly targeted therapies. This review summarizes the complex and interconnected molecular pathways implicated in phenotypic plasticity, both in the context of normal tissue homeostasis and cancer. Molecular pathways convergent between these contexts are highlighted while pathways enabling plasticity are distinguished from those that specify the phenotype of already plastic cells. Key unresolved questions in the field are discussed along with emerging technologies that may be used to help answer them.

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Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

Cited by 2 publications

References 259 publications

Radiation-induced senescence in glioblastoma: An overview of the mechanisms and eradication strategies

Radiation-induced senescence in glioblastoma: An overview of the mechanisms and eradication strategies

The molecular determinants of phenotypic plasticity in homeostasis and neoplasia

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