Cancer Drugs

Ambhaikar, Narendra B.

doi:10.1002/9781118354483.ch8

Cited by 1 publication

(1 citation statement)

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“…Hoffmann synthesized 2-substituted BT, captivated by its diverse activities and straightforward cyclization mechanism [9]. The fundamental structure of BTs comprises a fusion of a thiazole ring, which consists of a five-membered ring containing sulfur and nitrogen, with a benzene ring, forming a bicyclic structure [10][11][12]. This unique arrangement grants BTs their distinctive properties, making them intriguing subjects of study in both laboratory and industrial applications [13,14].…”

Section: Introductionmentioning

confidence: 99%

Pioneering Synthetic Strategies of 2-Substituted Benzothiazoles Using 2-Aminothiophenol

Teli,

Sethiya,

Agarwal

2024

Chemistry

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Heterocycles, compounds featuring heteroatoms like nitrogen, sulfur, and oxygen, are integral in fields such as synthesis, pharmacology, and medicine. Among these, benzothiazoles, formed by fusing thiazole with benzene, hold significant prominence. Their unique reactivity, especially at the carbon position between nitrogen and sulfur, has sparked wide interest. Notably, 2-substituted benzothiazoles exhibit diverse biological activities, including anticonvulsant, antimicrobial, and antioxidant properties, making them valuable in drug discovery. This review unveils an array of mesmerizing methods employed by chemists to prepare these compounds using 2-aminothiophenol as one of the precursors with other varied reactants. From novel strategies to sophisticated methodologies, each section of this review provides a glimpse into the fascinating world of synthetic chemistry of 2-substituted benzothiazoles. Delving into the diverse synthetic applications of 2-substituted benzothiazoles, this paper not only enriches our understanding of their synthesis but also sparks the imagination with the possibilities for future advancements.

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