Câncer gástrico em adultos jovens: um grupo de pior prognóstico?

Ramos, Marcus Fernando Kodama Pertille; Pereira, Marina Alessandra; Sagae, Victor Masaro Takamatsu; Mester, Marcelo; Morrell, André Luiz Gioia; Dias, André Roncon; Zilberstein, Bruno; Ribeiro, Ulysses; Cecconello, Ivan

doi:10.1590/0100-6991e-20192256

Cited by 18 publications

(21 citation statements)

References 26 publications

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“…The Lauren classification demonstrates numerous differences in etiology, epidemiology and pathology of gastric cancer and diffuse type gastric carcinomas often show a poor prognosis. [24][25][26][27] We observed that diffuse type gastric cancers have a poorer prognosis with shorter overall survival compared to intestinal type gastric cancer, consistent with the literature. Regarding tumor grade, we had conflicting results as we found a significant association between tumor grade and prognosis in Kaplan-Meier analysis and no significant association between tumor grade and survival in univariate and multivariate analyses.…”

Section: Discussionsupporting

confidence: 91%

ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort

et al. 2021

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Objective: Gastric cancer is among the most common human cancers with high mortality rates. ADAM10, a member of the ADAM (a disintegrin and metalloproteinase) family has also been found to be associated with gastric carcinoma and has been suggested as a potential therapeutic target. Here, we investigated the association of ADAM10 expression with prognosis in gastric adenocarcinoma patients that underwent gastric resection with D2 lymph node dissection. Methods: Total 86 consecutive patients that underwent resection for gastric adenocarcinoma were included. Immunohistochemical ADAM10 expression and its association with clinicopathological parameters were analyzed. Univariate and multivariate analyses and survival analyses were performed using SPSS ver.22. Results: High grade tumors, advanced stage tumors and diffuse type tumors showed significantly worse prognosis. A statistically significant association between ADAM10 expression and overall survival (OS) was observed in the univariate analysis, however, this association did not maintain its significance in the multivariate analysis. No statistically significant association was found ADAM-10 expression and clinicopathological parameters. Conclusion: Immunohistochemical ADAM10 expression may be used as a prognostic marker in gastric adenocarcinoma, however, introduction of a standardized immunohistochemical scoring system seems to be necessary for evaluation of ADAM10 staining. doi: https://doi.org/10.12669/pjms.37.2.3613 How to cite this:Alakus H, Kaya M, Ozer H, Egilmez HR, Karadayi K. ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3613 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 91%

ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort

et al. 2021

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“…GC patients were commonly classified into a young group and an old group; however, the cutoff value of age was different [8,9]. In this study, we chose 45 years of age as the cutoff age for analysis, which was consistent with the majority of previous studies [18][19][20].…”

Section: Discussionmentioning

confidence: 78%

The outcome of young vs. old gastric cancer patients following gastrectomy: a propensity score matching analysis

et al. 2021

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Purpose The purpose of the current study was to compare the postoperative complications, overall survival and disease-free survival in young and old gastric cancer patients after gastrectomy using propensity score matching (PSM). Methods Adult patients (aged ≥ 18 years) who underwent gastrectomy for gastric cancer in a single clinical center from January 2013 to December 2017 were enrolled continuously for retrospective analysis. To minimize the selection bias between the young and old groups, the PSM was conducted in this study. Results A total of 558 patients were included in this study, with 51 patients in the young group (aged ≤ 45 years) and 507 patients in the old group (aged > 45 years). After 1:1 matching according to PSM, 51 patients in the young group were matched to 51 patients in the old group. After PSM, there was no difference in the baseline information. In terms of short-term outcomes, no difference was found in operation time (P = 0.190), intraoperative blood loss (P = 0.336), retrieved lymph nodes (P = 0.948), blood transfusion (P = 0.339), postoperative hospital stay (P = 0.194), or postoperative complications (P = 0.477) between the two groups. For overall survival, no statistically significant difference was found in all stages (P = 0.383), stage I (P = 0.431), stage II (P = 0.875) or stage III (P = 0.446) gastric cancer. Furthermore, regarding disease-free survival, no differences were found between the two groups in all stages (P = 0.378), stage I (P = 0.431), stage II (P = 0.879) or stage III (P = 0.510) gastric cancer. Conclusion Age might not be an independent prognostic factor for short-term outcomes, OS, or DFS in gastric cancer patients who underwent gastrectomy. The pTNM stage of GC might be an independent prognostic factor for OS and DFS.

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“…Younger patients have fewer comorbidities and a higher tolerance for surgery and adjuvant chemotherapy than older patients [11,12]. Additionally, they can undergo intensive chemotherapy followed by gastrectomy with adequate lymph node dissection, which improves long-term prognosis [13,14]. However, some young patients present with rapidly progressive disease and distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Survival of Young Adults with Stage IV Gastric Cancer: A Japanese Population-based Study

Yamamoto

Honda

Kawamura

et al. 2021

Preprint

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Purpose: With the aging of society, the age of patients with gastric cancer (GC) in Japan has been increasing. However, there are few documented outcomes for young patients with stage IV GC. We investigated the clinical characteristics and prognosis of patients with stage IV GC aged under 40 years using a dataset from an integrated population-based cohort study.Methods: We conducted this multicenter population-based cohort study to determine whether earlier onset of GC was a poor prognostic factor. We enrolled patients with metastatic GC aged under 40 years (young group) and those aged between 60 and 75 years (middle-aged group). Patients were histologically diagnosed as having gastric adenocarcinoma. We evaluated the overall survival (OS) of both groups and the hazard ratio (HR) for OS based on age. The adjusted HR with 95% confidence interval (CI) was evaluated using the Cox proportional hazards model after adjusting for confounding factors, including sex, histology, number of metastatic lesions, surgical resection, and chemotherapy.Results: This study enrolled 555 patients. The patients were classified into the young group (n=20) and the middle-aged group (n=535). The median OS values were 5.7 months and 8.8 months in the young and middle-aged groups, respectively (P=0.029). The adjusted HR (95% CI) of the young group was 1.88 (1.17–3.04, P=0.009).Conclusions: Age was an independent prognostic factor in patients with stage IV GC. Further studies investigating the genomic characteristics of GC and exploring more effective chemotherapeutic agents are required.

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Câncer gástrico em adultos jovens: um grupo de pior prognóstico?

Cited by 18 publications

References 26 publications

ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort

ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort

The outcome of young vs. old gastric cancer patients following gastrectomy: a propensity score matching analysis

Clinical Features and Survival of Young Adults with Stage IV Gastric Cancer: A Japanese Population-based Study

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