Cancer Genetics and Genomics – Part 2

Brothwell, Morag; Barnett, Gillian C.

doi:10.1016/j.clon.2022.02.014

Clinical Oncology

2022

DOI: 10.1016/j.clon.2022.02.014

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Cancer Genetics and Genomics – Part 2

Morag Brothwell

Gillian C. Barnett

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2022

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Targeting Platelet Activation Pathways to Limit Tumour Progression: Current State of Affairs

Xulu

Augustine

2022

Pharmaceuticals

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The association between cancer and a hypercoagulatory environment is well described. Thrombotic complications serve not only as a major mortality risk but the underlying molecular structure and function play significant roles in enhancing tumour progression, which is defined as the tumour’s capacity to survive, invade and metastasise, amongst other hallmarks of the disease. The use of anticoagulant or antiplatelet drugs in cardiovascular disease lessens thrombotic effects, but the consequences on tumour progression require interrogation. Therefore, this review considered developments in the management of platelet activation pathways (thromboxane, ADP and thrombin), focusing on the use of Aspirin, Clopidogrel and Atopaxar, and their potential impacts on tumour progression. Published data suggested a cautionary tale in ensuring we adequately investigate not only drug–drug interactions but also those unforeseen reciprocal interactions between drugs and their targets within the tumour microenvironment that may act as selective pressures, enhancing tumour survival and progression.

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Targeting Platelet Activation Pathways to Limit Tumour Progression: Current State of Affairs

Xulu

Augustine

2022

Pharmaceuticals

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Cancer Genetics and Genomics – Part 2

Cited by 1 publication

References 33 publications

Targeting Platelet Activation Pathways to Limit Tumour Progression: Current State of Affairs

Targeting Platelet Activation Pathways to Limit Tumour Progression: Current State of Affairs

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