Cancer genetics program: Follow‐up on clinical genetics and genomic medicine in Qatar

Al-Bader, Salha Bujassoum; Alsulaiman, Reem; Bugrein, Hekmet; Omran, Tawfeg Ben; Abbaszadeh, Fatemeh; Bakheet, Nawal; Kusasi, Sitti Apsa; Abdou, Nema Mahmoud Ghobashy; Solomon, Benjamin D.; Ghazouani, Hafedh

doi:10.1002/mgg3.534

Cited by 7 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Significant mutations in PTEN gene was documented in breast cancer patients in Saudi Arabia [24]. Bujassoum et al demonstrated a variant of uncertain significance was more common than pathogenic variety in a mixed ethnic population similar to ours [25].…”

Section: Discussionsupporting

confidence: 78%

Clinicopathological characteristics of gene-positive breast cancer in the United Arab Emirates

et al. 2020

View full text Add to dashboard Cite

Introduction Breast cancer is the most prevalent cancer in the United Arab Emirates (UAE). This is the first study to provide data on predisposition of breast cancer susceptibility genes with associated clinical and pathological aspects in the UAE. Material & methods A retrospective chart review for breast cancer patients undergoing genetic testing from 2016 to 2018. According to National Comprehensive Cancer Network (NCCN) guidelines genetic testing was offered. The analyzed data included; age, ethnicity, family cancer history, pathogenic variant, histopathology, stage, molecular subtype and proliferation. Results 309 patients underwent genetic testing with a positive result in 130 patients (11.9%) over a period of 36 months. In 34.6% pathogenic and likely pathogenic variants were identified. BRCA2 was the most common gene identified. The mean age was 42.9 years (±9.01). Positive family history was identified in 66 patients (50.7%). Majority had stage 1 or 2 disease (66.2%), invasive ductal carcinoma (81.5%) and hormone receptor positive cancer (45.3%). Conclusions This is the first study in the UAE to describe the clinical and pathological characteristics of hereditary breast cancer in a mixed ethnic group with dominant Arabic population. Further genetic studies will be required in the UAE population, as the prevalence of breast cancer continues to rise.

show abstract

Section: Discussionsupporting

confidence: 78%

Clinicopathological characteristics of gene-positive breast cancer in the United Arab Emirates

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Several single nucleotide variations in either novel or rare genes involving in the BRCA1/2 pathway were detected [7]. Multiple genes were detected in Qatar during 2013 to 2018 that are associated with breast cancer, similar to many studies BRCA1 was the most common mutation detected, followed by BRCA2 [8]. Similarly, BRCA1 mutations were mostly associated with hereditary breast cancer in Oman and Bahrain [9,10].…”

Section: Consanguineous Marriages Are Very Common Among Thementioning

confidence: 66%

“…A positive family history was very common among Arabs with BRCA1&2. Although; patients who were unaffected form genetic mutations also had significant family history, which suggest genetic testing should not be based on family history alone [8].…”

Section: Consanguineous Marriages Are Very Common Among Thementioning

confidence: 99%

Genetic Predisposition of Breast Cancer in the United Arab Emirates

2021

Archives of Cancer Biology and Therapy

View full text Add to dashboard Cite

“…The key-points of cancer predisposition are as 7 follows: Most cancers have a multifactorial etiology and are attributable to a varying blend of genetic and environmental factors; only about 5% of common cancers are due to a strongly inherited susceptibility; A strong family history of the same or related cancers on the same side of the family (especially early-onset and multiple cancers) suggests a significant genetic predisposition and an increased risk of cancer to individuals in that family; A minority of cancers are due to monogenic cancer predisposition syndromes in which there is Mendelian inheritance with incomplete penetrance, conferring increased susceptibility to a characteristic spectrum of cancers; Identification of people with increased risk of cancer by considering the family genealogy is crucial as surveillance and prophylactic surgery may be indicated. Targeted chemoprophylaxis is under 5,6 investigation although some has been encouraged; Cancer genetics services and family clinics play an important role to evaluate the risk of an inherited cancer predisposition by performing genetic testing, surveillance, and preventive actions…”

Section: Cancer Risk Factorsmentioning

confidence: 99%

“…Laboratory results will determine the patient's eligibility for targeted therapy or lead the patient to have change(s) of lifestyle, prophylactic surgery, chemoprevention, or surveillance. It is a challenge for 5,6 clinical pathologists.…”

Section: Introductionmentioning

confidence: 99%

Cancer Risk Assessment and Screening; A Challenge for Clinical Pathology Service?

Kresno

2020

Indonesian J. Clin. Pathol. Med. Lab.

View full text Add to dashboard Cite

There is evidence demonstrating that cancer etiology is multi-factorial and modification of risk factors has achievedcancer prevention. There is therefore a need to advance the understanding of cancer etiology through interaction effectsbetween risk factors when estimating the contribution of an individual to the cancer burden in a population. It has beenknown that cancer may arise from genetic susceptibility to the disease as an intrinsic factor; however, non-intrinsic factorsdrive most cancer risk as well and highlight the need for cancer prevention. Are our clinical pathologists aware of thesefacts?. Are they ready to understand and to provide an excellent test with good expertise?. Hereditary cancer testing istypically performed using gene panels, which may be either cancer-specific or pan-cancer to assess risk for a defined orbroader range of cancers, respectively. Given the clinical implications of hereditary cancer testing, diagnostic laboratoriesmust develop high-quality panel tests, which serve a broad, genetically diverse patient population. The result will determinea patient's eligibility for targeted therapy, for instance, or lead a patient to prophylactic surgery, chemoprevention, andsurveillance. This review will introduce the definitions of intrinsic and non-intrinsic risk factors, which have been employed inrecent work and how evidence for their effects on the cancer burden in human subjects has been obtained. Genetic testingof cancer susceptibility genes by use of liquid biopsies and New Generation Sequencing (NGS) is now widely applied inclinical practice to predict the risk of developing cancer, help diagnosis, and treatment monitoring.

show abstract

Cancer genetics program: Follow‐up on clinical genetics and genomic medicine in Qatar

Abstract: This article presents an overview of the cancer genetics program in Qatar. In addition to summarizing clinical, research, educational, and other aspects, data related to testing outcomes (over the course of approximately 5.5 years) are presented.

Cited by 7 publications

References 6 publications

Clinicopathological characteristics of gene-positive breast cancer in the United Arab Emirates

Clinicopathological characteristics of gene-positive breast cancer in the United Arab Emirates

Genetic Predisposition of Breast Cancer in the United Arab Emirates

Cancer Risk Assessment and Screening; A Challenge for Clinical Pathology Service?

Contact Info

Product

Resources

About