Cancer Genomics in Precision Oncology: Applications, Challenges, and Prospects

Pereira, Michele Araújo; Lima, Marianna Kunrath; Couto, Patrícia Gonçalves Pereira; Penna, Michele Groenner; Alvim, Luige Biciati; Nani, Thaís Furtado; Freire, Maíra Cristina Menezes; Araujo, Luiz H.

doi:10.1007/978-981-15-1067-0_21

Cited by 20 publications

(10 citation statements)

References 236 publications

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“…The field of precision oncology appearing as the new branch of cancer research is essentially directed at strategizing cancer signaling-based targeted therapy by exploiting the peculiarities of the cancer genomes of the individuals for an efficient treatment. It is dedicated to studying the genetic profile of cancer cells to gain a thorough understanding of the signaling pathways and related molecular events during tumor growth and metastases and of drug resistance for a proper cure [156,157] Recent advances in cancer genomics and single-cell technologies have certainly made targeted therapy the accepted form of cancer treatment, and yet a huge amount of investment will be needed for future research, drug discovery, and diagnostics to fully unlock its potential and for their application in the management of cancer incidences in the time to come. Let us not forget that the socioeconomic burden of cancer remains high as the treatment options for most common cancers have been limited thus far and is an indication for a renewed approach to expedited drug development to bring effective anticancer agents from bench to bedside in a costeffective manner.…”

Section: Precision Oncology and Targeted Drug Therapy Of Cancermentioning

confidence: 99%

Precision Oncology-Based Targeting of Signaling Pathways toward a Holistic Approach to Cancer Therapeutics

Kumar¹

2023

Preprint

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The genetic changes appearing in the information system of the cell that program its unregulated growth and proliferation gradually lead to cancer manifestation, and the treatment options need to be guided accordingly. The critical roles played by some of the molecules associated with the signaling pathways and cell microenvironment that often induce tumorigenesis and metastasis have been described precisely in recent years based on findings of the human genome project and other related initiatives undertaken afterward to thoroughly understand the molecular basis of cancer cell behaviors. It is to rely upon the genomic study of cancer cells to fully understand the prognosis and pathways involved in disease progression to selectively target them for a cure. Furthermore, patients with the same cancer types often respond differently to cancer therapies, indicating the need for a patient-specific treatment regimen for cancer. In this direction, precision oncology, defined as the molecular profiling of tumors to identify targetable alterations for custom-tailored personalized treatment, is gaining ground as a potential means of cancer treatment and has started influencing the ways cancer has been treated in clinics. This article intends to comprehensively elucidate the foundations and frontiers of precision oncology in the context of recent advances in cancer genomics and single-cell technologies for assessing its scope and importance in the realization of a proper cure for cancer.

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Section: Precision Oncology and Targeted Drug Therapy Of Cancermentioning

confidence: 99%

Precision Oncology-Based Targeting of Signaling Pathways toward a Holistic Approach to Cancer Therapeutics

Kumar¹

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The field of precision oncology appearing as the new branch of cancer research is essentially directed at strategizing targeted drug therapy by exploiting the peculiarities of the cancer genomes of the individuals and/or a court of patients for desired results. It is dedicated to studying the genetic profile of cancer cells to gain a thorough understanding of the signaling pathways and related molecular events during tumor growth and metastases and of the mechanisms associated with drug resistance in cancer therapy for a possible cure [156,157] Recent advances in cancer genomics and single-cell technologies have certainly made targeted therapy the accepted form of cancer treatment, and yet a huge amount of investment will be needed for future research, drug discovery, and diagnostics to fully unlock its potential and for their application in the management of cancer incidences in the time to come. Let us not forget that the socioeconomic burden of cancer remains high as the treatment options for most common cancers have been limited thus far and is an indication for a renewed approach to expedited drug development to bring effective anticancer agents from bench to bedside in a cost-effective manner.…”

Section: Precision Oncology and Targeted Drug Therapy Of Cancermentioning

confidence: 99%

Precision Oncology-Based Targeting of Signaling Pathways toward a Holistic Approach to Cancer Therapeutics

Kumar¹

2023

Preprint

View full text Add to dashboard Cite

The mutational changes occurring in the regulatory genes responsible for the maintenance of optimal cell growth and proliferation gradually lead to cancer progression and metastasis. Furthermore, patients with the same cancer types often respond differently to different cancer therapies, indicating the need for a patient-specific treatment regimen for the disease. Precision oncology is the new field of cancer research that relies on genetic profiling of individual tumors to identify targetable alterations for custom-tailored personalized treatment of the disease. It is to rely upon the genomic study of cancer cells to get a clear picture of the prognosis and pathways involved in disease progression and to look for the means to selectively target them for a cure. This article intends to briefly explain the foundations and frontiers of precision oncology in the context of technological advances being made in this direction to assess its scope and importance in the realization of a proper cure for cancer.

show abstract

“…The field of precision oncology appearing as the new branch of cancer research is essentially directed at strategizing targeted drug therapy by exploiting the peculiarities of the cancer genomes of the individuals and/or a court of patients for desired results. It is dedicated to studying the genetic profile of cancer cells to gain a thorough understanding of the signaling pathways and related molecular events during tumor growth and metastases and of the mechanisms associated with drug resistance in cancer therapy for a possible cure [158,159]. Let us not forget that the socioeconomic burden of cancer remains high as the treatment options for most common cancers have been limited thus far and is an indication for a renewed approach to expedited drug development to bring effective anticancer agents from bench to bedside in a costeffective manner.…”

Section: Precision Oncology and Targeted Drug Therapy Of Cancermentioning

confidence: 99%

Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to

Kumar¹

2023

Preprint

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30 The mutational changes occurring in the regulatory genes responsible for the maintenance of 31 optimal cell growth and proliferation gradually lead to cancer progression and metastasis. 32 Furthermore, patients with the same cancer types often respond differently to different cancer 33 therapies, indicating the need for a patient-specific treatment regimen for the disease. Precision 34 oncology is the new field of cancer research that relies on genetic profiling of individual tumors 35 to identify targetable alterations for custom-tailored personalized treatment of the disease. It is to 36 rely upon the genomic study of cancer cells to get a clear picture of the prognosis and pathways 37 involved in disease progression and to look for the means to selectively target them for a cure. 38 This article intends to briefly explain the foundations and frontiers of precision oncology in the 39 context of technological advances being made in this direction to assess its scope and importance 40 in the realization of a proper cure for cancer. 41 42

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Cancer Genomics in Precision Oncology: Applications, Challenges, and Prospects

Cited by 20 publications

References 236 publications

Precision Oncology-Based Targeting of Signaling Pathways toward a Holistic Approach to Cancer Therapeutics

Precision Oncology-Based Targeting of Signaling Pathways toward a Holistic Approach to Cancer Therapeutics

Precision Oncology-Based Targeting of Signaling Pathways toward a Holistic Approach to Cancer Therapeutics

Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to

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