Cancer? In Africa?

Morris, Kelly

doi:10.1016/s1470-2045(03)00969-0

Cited by 68 publications

(39 citation statements)

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“…KSHV infection is the most common cause of malignancies among patients infected with HIV, and coinfection is a common affliction among young individuals in many parts of the world (36,37). The K13 protein is one of the few KSHV proteins to be expressed in latently infected Kaposi's sarcoma spindle and PEL cells and a prime candidate for playing a causative role in the pathogenesis of KSHV-associated malignancies (38,39).…”

Section: Discussionmentioning

confidence: 99%

NEMO Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Encoded vFLIP K13-Induced Gene Expression and Protection against Death Receptor-Induced Cell Death, and Its N-Terminal 251 Residues Are Sufficient for This Process

Tolani

Matta

Gopalakrishnan

et al. 2014

J Virol

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IMPORTANCEKaposi's sarcoma-associated herpesvirus-encoded vFLIP K13 is believed to protect virally infected cells against death receptorinduced apoptosis and to activate the NF-B pathway by binding to adaptor protein NEMO/IKK␥. However, whether K13 can also induce gene expression independently of NEMO and the minimum region of NEMO that is sufficient for supporting K13-induced NF-B remain to be delineated. Furthermore, the contribution of NEMO and NF-B to the protective effect of K13 against death receptor-induced apoptosis is not clear. We demonstrate that NEMO is required for modulation of K13-induced genes and its N-terminal 251 amino acids are sufficient for supporting K13-induced NF-B. The ability of K13 to protect against TNF-␣-induced cell death is critically dependent on its ability to interact with NEMO and activate NF-B. Our results suggest that K13-based gene therapy approaches may have utility for the treatment of patients with NEMO mutations and immunodeficiency.

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Section: Discussionmentioning

confidence: 99%

NEMO Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Encoded vFLIP K13-Induced Gene Expression and Protection against Death Receptor-Induced Cell Death, and Its N-Terminal 251 Residues Are Sufficient for This Process

Tolani

Matta

Gopalakrishnan

et al. 2014

J Virol

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“…This is may be partially due to the short-life expectancy and young population structure of African women. However, the full spectrum of this phenomenon could relect complex gene-environment interactions associated with both traditional and new lifestyles in Africa [6,17,19,[28][29][30][31][32].…”

Section: Major Clinicopathological Features Of Breast Cancer In Sudanmentioning

confidence: 99%

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Mariani–Costantini¹,

Elhassan²,

Aceto³

et al. 2017

Breast Cancer - From Biology to Medicine

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Litle is known about breast cancer in Sudan. According to the recent data published by the Khartoum Cancer Registry, breast cancer was the most common cancer among Sudanese women. Generally, breast cancer in native African women is characterized by young age at onset, occurrence in multiparous premenopausal patients, advanced stage at diagnosis, large tumor size, high-grade and triple-negative phenotype, with correspondingly poor prognosis. In Sudan, it was reported that about 70% of the women diagnosed with breast cancer were younger than 50 years old. We present here data from local and international publications as well as primary information from the National Cancer Institute in Wad Medani (one of the only two cancer hospitals of the country, both located in Central Sudan in Khartoum and Wad Medani). We provide an up-to-date situation analysis of breast cancer in Central Sudan as an example for an African reality and the various open challenges of breast cancer in a limited resource seting. A beter understanding of breast cancer in black African women is of global relevance, as there is an alarming increase in breast cancer among young black women worldwide, and these patients have the lowest survival rates.

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“…The incidence of cancer and HIV/AIDS in many developing countries is increasing (4,8), and these figures do not take into account other chronic illnesses like diabetes, heart disease and lung disease, which also cause symptoms that are distressing such as shortness of breath, constipation, diarrhea, nausea as well as psychological distress, depression and anxiety. Including family members, or close companions, providing care and support to those who are dying raises the number of people benefiting from palliative care to a potential 100 million a year (and possibly more (9)) (1).…”

mentioning

confidence: 99%