Cancer in children and young adults born after assisted reproductive technology: a Nordic cohort study from the Committee of Nordic ART and Safety (CoNARTaS)

Sundh, Karin Jerhamre; Henningsen, Anna-Karina Aaris; Källén, Karin; Bergh, Christina; Romundstad, Liv Bente; Gissler, Mika; Pinborg, Anja; Skjærven, Rolv; Tiitinen, Aila; Vassard, Ditte; Lannering, Birgitta; Wennerholm, Ulla‐Britt

doi:10.1093/humrep/deu143

Cited by 76 publications

(95 citation statements)

References 43 publications

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“…Moreover, neither parental age nor ART seems to be associated with an increased cancer risk in our study cohort. This is in line with previous findings that children born after ART are not at increased cancer risk [15,17].…”

Section: Discussionsupporting

confidence: 93%

Genetic predisposition in children with cancer – affected families' acceptance of Trio-WES

et al. 2017

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A considerable percentage of childhood cancers are due to cancer predisposition syndromes (CPS). The ratio of CPSs caused by inherited versus de novo germline mutations and the risk of recurrence in other children are unknown. We initiated a prospective study performing whole-exome sequencing (WES) of parent-child trios in children newly diagnosed with cancer. We initially aimed to determine the interest in and acceptance of trio WES among affected families and to systematically collect demographic, medical, and family history data to analyze whether these point to an underlying CPS. Between January 2015 and December 2016, 83 (88.3%) of 94 families participated; only 11 (11.7%) refused to participate. Five (6.0%) children presented with congenital malignancies and three (3.6%) with tumors with a high likelihood of an underlying CPS. Two (2.5%) families showed malignancies in family members < 18 years, 11 (13.8%) showed relatives < 45 years with cancer, 37 (46.3%) had a positive cancer history, and 14 (17.5%) families had > 1 relative with cancer.Conclusions: Genetic testing in pediatric oncology is of great interest to the families, and the vast majority opts for investigation into potentially underlying CPSs. Trio sequencing provides unique insights into CPS in pediatric cancers and is increasingly becoming a common approach in modern oncology, and thus, trio sequencing needs also to be integrated routinely into the practice of pediatric oncology.

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Section: Discussionsupporting

confidence: 93%

Genetic predisposition in children with cancer – affected families' acceptance of Trio-WES

et al. 2017

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“…A total of 12 studies including 2,786,687 participants and 13,319 cases were selected in this meta-analysis of acute childhood leukemia [12][13][14][15][16][17][18][19][20][21][22][23]. The results suggested that preterm birth was significantly associated with an increased risk of acute childhood leukemia when compared to full-term birth (OR = 1.09, 95% CI = 1.02-1.17), with mild heterogeneity (I 2 = 12.0 %, P = 0.33) (Fig.…”

Section: Main Analysismentioning

confidence: 99%

Preterm Birth and Subsequent Risk of Acute Childhood Leukemia: a Meta-Analysis of Observational Studies

Huang¹,

Gao²,

Zhong³

et al. 2016

Cell Physiol Biochem

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Background: Preterm birth (PTB) has been recognized as a crucial long term risk factor for multiple non-communicable diseases. However, studies between the relationship of PTB and the risk of acute childhood leukemia have yielded inconclusive results. Therefore, we performed a meta-analysis to systematically review the current literature to investigate whether PTB is associated with increased risk of acute childhood leukemia. Methods: Three electronic databases (PubMed, Web of Science, and EMBASE) were searched up to December 1st, 2015. Relevant studies reporting the association between PTB and subsequent risk of acute childhood leukemia were included for further evaluation. Statistical analysis was performed using Revmen 5.3 and Stata 10.0. Results: A total of 12 studies for acute childhood leukemia, eight studies for acute lymphoblastic leukemia (ALL), and seven studies for acute myeloid leukemia (AML) were included in the current meta-analyses. We calculated pooled odds ratio (OR) and 95% confidence interval (CI) to evaluate the relationship between PTB and acute childhood leukemia as well as its two subtypes: ALL and AML. Our results suggested that PTB was significantly associated with increased risk of acute childhood leukemia (OR = 1.09, 95% CI = 1.02-1.17, P = 0.01) and AML (OR = 1.42, 95% CI = 1.21-1.67, P < 0.01). However, PTB was not significantly associated with an increased risk of ALL (OR = 1.04, 95% CI = 0.96-1.13, P = 0.29). Conclusion: Our data showed that PTB increased the risk of AML. Further studies are required to explore causality and dissect the biological mechanisms involved.

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“…Скандинавский Комитет по ВРТ и безопасности (CoNARTaSgroup) недавно опубликовал результаты масштабного реестрового исследования, где пред-ставлены данные о заболеваемости раком у детей, за-чатых с помощью методов ЭКО [62]. Не было выяв-лено значительного повышения рисков возникнове-ния каких-либо форм рака у детей, зачатых с исполь-зованием методов ЭКО, по сравнению с популяцией (AOR Рост, физическое и когнитивное развитие в раннем детстве у детей, зачатых с использованием методов ЭКО В ряде исследований оценивался рост детей, за-чатых с использованием методов ЭКО, по сравне-нию с детьми из общей популяции.…”

Section: заболеваемость раком после экоunclassified

Neonatal outcome after IVF

Sazonova¹

2016

Probl. reprod.

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Cancer in children and young adults born after assisted reproductive technology: a Nordic cohort study from the Committee of Nordic ART and Safety (CoNARTaS)

Cited by 76 publications

References 43 publications

Genetic predisposition in children with cancer – affected families' acceptance of Trio-WES

Genetic predisposition in children with cancer – affected families' acceptance of Trio-WES

Preterm Birth and Subsequent Risk of Acute Childhood Leukemia: a Meta-Analysis of Observational Studies

Neonatal outcome after IVF

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