Cancer in older men: A gender-based review

Cepeda, Oscar A.; Gammack, Julie K.

doi:10.1080/13685530600804091

Cited by 12 publications

(8 citation statements)

References 50 publications

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“…Interestingly we observed that age-matched men from the highest SEIFA quintile were at an increased risk of ever having cancer. In surveillance studies, lower SEIFA quintiles have generally been shown to associate with increased morbidity and mortality [ 44 ]. It has been argued that improvements in recent years in cancer screening and awareness may have created an artificially high impression of cancer prevalence amongst affluent American men [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic disease prevalence and associations in a cohort of Australian men: The Florey Adelaide Male Ageing Study (FAMAS)

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Chronic disease prevalence and associations in a cohort of Australian men: The Florey Adelaide Male Ageing Study (FAMAS)

et al. 2008

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“…These results suggest that the high expression level of SCIN in prostate cancer may be involved in the pathogenesis of prostate cancers. Previous studies suggest that prostate cancer is associated with age and gender of patients (21,22). To investigate the association of SCIN expression with these two factors, we analyzed the SCIN expression level in prostate cancer tissues with different factors.…”

Section: Scin Is Highly Expressed In Prostate Cancermentioning

confidence: 99%

Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest

Wang

Sun

et al. 2013

International Journal of Oncology

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DNA polymerase kappa (POLkappa) is a low fidelity translesional DNA polymerase implicated in spontaneous and DNA damage-induced mutagenesis. We have previously shown that POLkappa was frequently overexpressed in human lung cancer tissues as compared with their matched non-tumorous tissue counterpart. In the present study, we found a close correlation between elevated POLkappa expression and p53 inactivation in lung cancer tissues. To investigate whether POLK expression might be regulated by p53, we have determined the transcriptional initiation site of POLK gene and examined its promoter activity in A549, H358-129, and PC-3 human lung cancer cell lines. Wild-type p53, but not a mutant p53 (R273H) devoid of the DNA-binding activity, strongly inhibited POLK promoter activity in these cells. In addition, POLK promoter exhibited a significantly higher activity in p53-/- murine embryo fibroblasts (MEF) than in p53+/- and p53+/+ MEF. These results link p53 status with POLkappa expression and suggest that loss of p53 function may in part contribute to the observed POLkappa upregulation in human lung cancers.

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“…Five-year survival for colorectal cancer is between 50-60 %, with females experiencing better survival rates than males despite the fact that women tend to be diagnosed with more advanced cancer compared with men [23][24][25]. Survival following diagnosis relates in part to the location of the cancer, with better prognosis for distal cancers -that is cancers that are further away from the centre of the body.…”

Section: Survivalmentioning

confidence: 95%

Not an equal opportunity disease – a sex and gender-based review of colorectal cancer in men and women: Part I

Payne¹

2007

The Journal of Men's Health & Gender

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This paper reviews the literature on colorectal cancer from a sex and gender-based perspective. Colorectal cancer is a major cause of death in the developed world, with rates increasing in developing countries. Although described by some writers as an 'equal opportunity' disease, it presents more risk to men than women. Both biological, or sex-linked factors, and gender-linked factors play a part in the aetiology of the disease, while gender differences in the use of screening and treatment also help shape the mortality gap between women and men for this condition. Without an appreciation of the part played by sex and gender in the risk of colorectal cancer, and without a gender-sensitive approach to screening in particular, it is possible that the mortality gap between men and women for this condition will widen in the future. ß 2007 WPMH GmbH. Published by Elsevier Ireland Ltd.There is an increasingly sophisticated understanding in medical science of the parts played by sex and gender in shaping the health of men and women, with an emerging specialism of gender medicine, alongside greater recognition of the need for gender-sensitive research and health care. However, gender is more commonly taken into account in areas of health where differences between women and men are particularly marked, for example in relation to specific conditions such as coronary heart disease, or health behaviours such as smoking. It is important to extend this debate to conditions where the differences between women and men appear to be less notable. Men and women largely die of the same conditions: worldwide around 27% of males and 32% of females die from cardiovascular disease, around 19% of both males and females die from infectious and parasitic diseases and 13% of men compared with 12% of women die from cancer [1]. While one difference between women and men that explains the gap in life expectancy is that women suffer many of the same health risks as men but at a later point in their life course, it is also important to consider the sex and gender differences influencing women's and men's risk of specific conditions such as cancer.This paper adopts a multi-disciplinary approach to explore sex and gender differences in the risk of colorectal cancer and in the role of screening to detect and treat early symptoms of the disease. The premise on which this paper is based is that an individual's risk profile for this disease is shaped by both biologically determined factors that influence vulnerability to the condition and gender or socially shaped factors that 1 Read the second part of this review in

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Cancer in older men: A gender-based review

Cited by 12 publications

References 50 publications

Chronic disease prevalence and associations in a cohort of Australian men: The Florey Adelaide Male Ageing Study (FAMAS)

Chronic disease prevalence and associations in a cohort of Australian men: The Florey Adelaide Male Ageing Study (FAMAS)

Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest

Not an equal opportunity disease – a sex and gender-based review of colorectal cancer in men and women: Part I

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