Cancer in patients admitted to hospital with diabetes mellitus aged 30 years and over: record linkage studies

Abstract

Aims/hypothesis The aim of this study was to determine the risk of cancer in people admitted to hospital for diabetes mellitus when aged 30 or older. Methods This study involved the analysis of two statistical datasets of linked hospital and mortality data, in an area in southern England, between 1963 and 1998 Conclusions/interpretation Diabetes mellitus was associated with an elevated risk of some site-specific cancers and a reduction of risk of others. Considering the risk in diabetes of all cancers combined, the elevation of risk, if any, is likely to be small and numerically less important than other known complications of diabetes.

Glucose-lowering agents and the patterns of risk for cancer: a study with the General Practice Research Database and secondary care data

“…It is unlikely that glucose-lowering agents can cause pancreatic cancer within days of starting medication. Decreased rates of prostate cancer and NMSC have been reported in the literature [12,13] and also found in the present study. But the evidence is inconsistent for colorectal and breast cancer.…”

“…With respect to the association between type of cancer and diabetes, pancreatic cancer is one of the types most strongly associated with diabetes, as found in the present study and reported in literature [12,13]. The most likely explanation for this increased risk of pancreatic cancer is protopathic bias; an alternative explanation is detection bias.…”

“…The present study and a recent large UK study linking hospital admission records and death certificates [12] found that diabetes was not associated with an increased risk of cancer overall, as both reported relative rates close to unity. With respect to the association between type of cancer and diabetes, pancreatic cancer is one of the types most strongly associated with diabetes, as found in the present study and reported in literature [12,13].…”

Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies

“…From these 44 studies, 18 were rejected because they did not focus on incidence of lymphoma, leukemia, or myeloma; did not focus on DM2; or were cross-sectional. Finally, 26 studies (13 prospective cohort 10-22 and 13 case-control [23][24][25][26][27][28][29][30][31][32][33][34][35] ) were included in our analysis. …”

Plasma insulin, C‐peptide and blood glucose and the risk of gastric cancer: The Japan Public Health Center‐based prospective study

“…Some prospective studies reported that DM determined by questionnaire or medical records is positively associated with gastric cancer, [3][4][5][6] but others found a null association. [7][8][9][10][11][12] However, DM can be easily misclassified when based on self-report of disease in questionnaire survey or medical records. To overcome this problem, several studies were directly based on diabetic biomarkers, such as hemoglobin A1c (HbA1c) and blood glucose, but the associations were also inconsistent in these prospective studies.…”