Cancer in patients with HIV infection: A new epidemiology

Kodali, Sucheel K.; Kancharla, Pragnan; Naik, SK; Sangal, Ashish; Rathnasabapathy, C.; Muhammad, Khushi; Berger, Bernhard; He, Zili; Kalavar, Madhumati

doi:10.1200/jco.2008.26.15_suppl.11108

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“…This double infection further decreases the cellular and humoral immune functions, resulting in a decrease in HPV clearance ability [6][7][8][9] . Persistent HPV infection leads to a significant increase in the incidence of cervical epithelial precancerous lesions, which eventually leads to the occurrence and rapid progression of invasive cervical cancer [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

HIV-1-infected cell-derived exosomes promote the growth and progression of cervical cancer

Chi

et al. 2019

Int. J. Biol. Sci.

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Background: Women infected with HIV are more likely to have aggressive cervical cancer, and patients with HIV infection are often more severely ill than those without HIV infection. However, the underlying mechanism for the progression of cervical cancer is not yet fully understood and requires further research. Methods: Exosomes were isolated from cell culture supernatants using differential ultracentrifugation. Confirmation of exosome isolation was based upon identification by electron microscopy and NanoSight particle tracking analysis of the purified fraction. The function of exosomes derived from HIV-infected T-cells in cervical cancer was determined by CCK8 and Transwell invasion assays. Results: Exosomal miR-155-5p derived from HIV-infected T-cells promotes the proliferation, migration and invasion of cervical cancer cells. Furthermore, we found that HIV-infected T-cells secrete exosomal miR-155-5p that directly targets ARID2 degradation, leading to activation of the NF-κB signaling pathway. MiR-155-5p promotes cervical cancer progression by secreting proinflammatory cytokines, including IL-6 and IL-8. Conclusions: In conclusion, we demonstrate that intercellular crosstalk between HIV-infected T-cells and cervical cancer is mediated by exosomes from HIV-infected T-cells that contribute to the malignant progression of cervical cancer, providing potential targets for the prevention and treatment of HIV-associated cervical cancer.

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Section: Introductionmentioning

confidence: 99%

HIV-1-infected cell-derived exosomes promote the growth and progression of cervical cancer

Chi

et al. 2019

Int. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

Cancer in patients with HIV infection: A new epidemiology

Cited by 1 publication

References 0 publications

HIV-1-infected cell-derived exosomes promote the growth and progression of cervical cancer

HIV-1-infected cell-derived exosomes promote the growth and progression of cervical cancer

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