Cancer in the Immunosuppressed Patient

Whelan, Patrick; Scadden, David T.

doi:10.1007/0-387-31056-8_96

Cited by 3 publications

(2 citation statements)

References 292 publications

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“…378 schwedische RAPatienten, bei denen es später zu einem malignen Lymphom kam, wurden in einer Fall-Kontroll-Studie über 30 Jahre hinweg rekrutiert. Aufgrund von seriellen Untersuchungen (Zahl der schmerzempfindlichen und geschwollenen Gelenke), Gesamtbeurteilung der Krankheitsaktivität durch den Arzt und Blutsenkungsrate wurde ein kumulativer Punktwert für die Krankheitsaktivität ermittelt: [32]. Man ist versucht, zu spekulieren, dass bestimmte Patienten mit RA unabhängig von ihrer medikamentösen Therapie eine bestimmte Art von Immundysfunktion haben, die diese Anfälligkeit für DLBCL erklären könnte, welche RA-Patienten mit anderen immunsupprimierten Patienten gemein haben.…”

Section: Lymphomeunclassified

Der Zusammenhang zwischen rheumatoider Arthritis und Krebs

Whelan

2006

Z. Rheumatol.

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Because it is a systemic disorder, rheumatoid arthritis (RA) is known to predispose affected individuals to other organ manifestations as well as arthritic problems. The serious complications include pericarditis, pulmonary and cutaneous nodules, episcleritis, and rheumatoid vasculitis. Of late, a significantly increased incidence of lymphoma has also accumulated. The overall risk is about double than in the general population, but that in patients with the most severe arthritis is dramatically higher. Men with RA appear to have an extremely elevated risk of Hodgkin's disease, which has also been observed at a higher incidence among the children of affected patients. These lymphomas are not typically infected with EBV, though RA patients have a defective capacity to control systemic EBV infection. Increasing attention is being paid to the effect of RA treatments on development of lymphoma, and some patients with EBV-positive tumors who have been taking methotrexate have shown a positive response after just discontinuing this drug. More controversial is the question of whether anti-TNF alpha agents involve an increased risk of lymphoma; in light of the conflicting evidence this matter is still unresolved.

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Section: Lymphomeunclassified

Der Zusammenhang zwischen rheumatoider Arthritis und Krebs

Whelan

2006

Z. Rheumatol.

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“…HIV infection has been calculated to increase the likelihood of developing a lymphoma by 60–110 times [ 5 , 6 ]. As noted by the World Health Organization (WHO), HIV/AIDS-related lymphomas are predominantly B-cell lymphomas [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Lymphoproliferative Lesions in the Setting of HIV Infection: A Five-Year Retrospective Case Series and Review

Mahé

Ross

Sur

2011

Pathology Research International

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A wide variety of noninfectious lesions have been identified in association with HIV infection. Many hematolymphoid lesions are possible in this patient group, both reactive and neoplastic. Epidemiologic data suggests that lymphoid malignancies are among the most common neoplasms in patients with HIV. We present a selective case series assembled over a 5-year period from the relatively low HIV-prevalence Hamilton Regional Laboratory Medicine Program (HRLMP), a tertiary care referral centre in Southern Ontario. This series serves to demonstrate the wide variety of lymphoid lesions that may be encountered in patients with HIV. In addition to outlining the pathologic work-up necessary in these cases, we discuss characteristics that distinguish the HIV-associated lesions from the pathobiologically similar non-HIV-associated lymphoid lesions.

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Benign and Malignant Lymphoproliferative Disorders in HIV/AIDS

Mahé¹,

Sur²

2011

HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies

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Cancer in the Immunosuppressed Patient

Cited by 3 publications

References 292 publications

Der Zusammenhang zwischen rheumatoider Arthritis und Krebs

Der Zusammenhang zwischen rheumatoider Arthritis und Krebs

Lymphoproliferative Lesions in the Setting of HIV Infection: A Five-Year Retrospective Case Series and Review

Benign and Malignant Lymphoproliferative Disorders in HIV/AIDS

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