Cancer incidence and mortality in France in 1975–95

Ménegoz, F; Rj, Black; Arveux, Patrick; Magne, V.; Ferlay, Jacques; Buémi, Antoine; Carli, Paule‐Marie; Chapelain, G.; Faivre, Jean; Gignoux, M; Grosclaude, Pascale; Macé-Lesec'h, J; Raverdy, N.; Schaffer, P.

doi:10.1097/00008469-199710000-00005

Cited by 101 publications

(42 citation statements)

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“…1,2 NHL are among the tumor localizations for which an increased risk has been associated with farm-related activities, including use of pesticides. 3 With the aim to further assess the risk of cancer associated to occupational exposure to pesticides, we are currently conducting an epidemiological and biological prospective study among farmers in Calvados (Normandy, France) using various biomarkers.…”

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confidence: 99%

BCL‐2/J_H translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features

Roulland

Lebailly

Roussel

et al. 2003

Intl Journal of Cancer

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Key words: BCL-2/J H translocation; biomarker; healthy; lymphocytesThe incidence of Non-Hodgkin's lymphoma (NHL) presents a 6 -8% increase since the 1970s for largely unknown reasons, even if AIDS in the USA and modification of diagnosis could play a role. 1,2 NHL are among the tumor localizations for which an increased risk has been associated with farm-related activities, including use of pesticides. 3 With the aim to further assess the risk of cancer associated to occupational exposure to pesticides, we are currently conducting an epidemiological and biological prospective study among farmers in Calvados (Normandy, France) using various biomarkers. Considered as an early step in lymphomagenesis, the translocation t(14;18)(q32;q21) between the BCL-2 protooncogene and the J H immunoglobulin gene region 4,5 will be used to assess the effect of pesticide exposure. Occurring in 85% of human follicular lymphoma and in 20% of diffuse large cell lymphoma, 6 it is also present in peripheral blood lymphocytes of healthy individuals. [7][8][9][10][11][12] Before studying the effect of pesticide exposure among farmers, it is necessary to evaluate the influence of potential confounding factors. Pesticide use follows a temporal cycle with potential effects on biomarkers of season-related environmental factors. We determined the characteristics of BCL-2/J H rearrangements in peripheral blood lymphocytes collected in winter (lowest pesticide exposure period) and at the end of spring (peak pesticide exposure period) from healthy individuals living in the same region and not involved in farming or pesticide handling. MATERIAL AND METHODS Study populationPeripheral blood lymphocytes were obtained, after authorization of the local ethical committee, from 33 healthy men recruited among white collar workers, laboratory or radiology staff in January 1999 and at the end of spring (May 1999). Information on age, workplace and smoking habits were recorded. Sample preparationMononuclear cells were isolated from peripheral blood by Ficoll-Hypaque gradient centrifugation. The cells were washed 2ϫ in PBS and then the samples were then cryopreserved in 20% FCS and 10% DMSO. DNA was isolated using standard procedure. 13 Briefly, cells were thawed at 37°C and washed in PBS. After centrifugation, they were resuspended in TEN-SDS 10% (10 mM Tris-HCl pH ϭ 7.4, 25 mM EDTA, 100 mM NaCl) with 1 mg/ml of proteinase K and incubated overnight at 56°C. DNA was extracted 3ϫ in phenol/chloroform/isoamylalcohol (25:24:1) and precipitated by sodium acetate 0.3 M/absolute ethanol at Ϫ20°C. The concentration and purity of the DNA was determined by spectrophotometry at 260 and 280 nm.

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confidence: 99%

BCL‐2/J_H translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features

Roulland

Lebailly

Roussel

et al. 2003

Intl Journal of Cancer

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“…1,2 Epidemiological studies have supported a model in which the majority of cases are sporadic with a small percentage being due to the presence of dominantly inherited susceptibility alleles. 3 Two such genes, BRCA1 and BRCA2, have been identified and found to be mutated in a large number of families with multiple cases of early-onset breast or ovarian cancer.…”

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confidence: 99%

Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population

2001

Intl Journal of Cancer

193

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The main focus of this German-wide multi-center study was to establish a BRCA1/2 mutation profile and to determine family types with high frequencies of mutations in these genes. In a comprehensive study, the entire coding sequences of the breast cancer genes BRCA1 and BRCA2 were analyzed in 989 unrelated patients from German breast/ovarian cancer families. A total of 77 BRCA1 and 63 BRCA2 distinct deleterious mutations were found in 302 patients. More than 1 ⁄3 of these mutations are novel and might be specific for the German population. Eighteen common mutations were found in 68% of cases in BRCA1 and 13 recurrent mutations in 44% of cases in BRCA2, facilitating prescreening approaches. Haplotype analysis indicate that 14 out of 20 recurrent mutations are likely originating from a common founder. An additional 50 different rare sequence variants with unknown relevance for tumorigenesis were found in 72 families. Correlation of BRCA1/BRCA2 detection rates with family history identified families with both breast and ovarian cancer to be at highest risk for BRCA1/BRCA2 mutations (43% and 10%, respectively), followed by families with at least 2 premenopausal cases of breast cancer (24% BRCA1 and 13% BRCA2 mutations). These data provide strong evidence for further predisposing genes in the German population. In breast cancer families with 2 or 3 affected females but only a single or no premenopausal case, mutations were detected with low frequencies (about 10% or less for both genes). The decision for or against molecular diagnosis is now aided by considering the expected mutation detection rates that greatly depend on family history and structure.

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“…Previous studies have shown that right colon tumors occur most of the time at older ages. The immunological study of proximal tumors is also different from that of the distal colon [42,43]. In a study conducted in Iran between 2008 and 2013 [44], the anatomical study and distribution of tumors was similar in the left colon (32.6%) and the right colon (29.5%).…”

Section: Discussion:-mentioning

confidence: 99%

Colorectal Cancer in Marrakech Tensift Elhaouz, Epidemiological and Anatomopathological Aspects, About 2584 Cases in 19 Years.

Rabbani¹,

Hakam²,

Narjis³

et al. 2017

IJAR

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Cancer incidence and mortality in France in 1975–95

Cited by 101 publications

References 0 publications

BCL‐2/J_H translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features

BCL‐2/J_H translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features

Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population

Colorectal Cancer in Marrakech Tensift Elhaouz, Epidemiological and Anatomopathological Aspects, About 2584 Cases in 19 Years.

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Cancer incidence and mortality in France in 1975–95

Cited by 101 publications

References 0 publications

BCL‐2/JH translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features

BCL‐2/JH translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features

Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population

Colorectal Cancer in Marrakech Tensift Elhaouz, Epidemiological and Anatomopathological Aspects, About 2584 Cases in 19 Years.

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Product

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BCL‐2/J_H translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features

BCL‐2/J_H translocation in peripheral blood lymphocytes of unexposed individuals: Lack of seasonal variations in frequency and molecular features