Cancer incidence and mortality patterns in South Eastern Europe in the last decade: Gaps persist compared with the rest of Europe

Znaor, Ariana; Hurk, Corina van den; Primic-Žakelj, Maja; Agius, Dominic; Coza, Daniela; Demetriou, Anna; Dimitrova, Nadya; Eser, Sultan; Karakilinc, Hulya; Živković, Snežana; Bray, Freddie; Coebergh, Jan Willem

doi:10.1016/j.ejca.2012.11.030

Cited by 68 publications

(59 citation statements)

References 22 publications

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“…This phenomenon has also been observed in the Netherlands since the mid-1990s in women <50 years old [25]. In southern Europe, declines in male incidence were also reported by Znaor et al in central Serbia over the 1999-2008 period [26]. While the peak of lung cancer cases seems to have been reached in men, as already reported by Malvezzi et al [27], our analyses indicate that it has not yet been reached in women.…”

Section: Lung Cancersupporting

confidence: 87%

Convergence of decreasing male and increasing female incidence rates in major tobacco-related cancers in Europe in 1988–2010

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Rentería

Sharp³

et al. 2015

European Journal of Cancer

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Introduction: Smoking prevalence has been declining in men all over Europe, while the trend varies in European regions among women. To study the impact of past smoking prevalence, we present a comprehensive overview of the most recent trends in incidence, during 1988-2010, in 26 countries, of four of the major cancers in the respiratory and upper gastro-intestinal tract associated with tobacco smoking. Methods: Data from 47 population-based cancer registries for lung, laryngeal, oral cavity and pharyngeal, and oesophageal cancer cases were obtained from the newly developed data repository within the European Cancer Observatory (http://eco.iarc.fr/). Truncated agestandardised incidence rates (35-74 years) by calendar year, average annual percentage change in incidence over 1998-2007 were calculated. Smoking prevalence in selected countries was extracted from the Organisation for Economic Co-operation and Development and the World Health Organization databases. Results: There remained great but changing variation in the incidence rates of tobacco-related cancers by European region. Generally, the high rates among men have been declining, while the lower rates among women are increasing, resulting in convergence of the rates. ScienceDirectj o u r n a l h o m e p a g e : ww w . e j c a n c e r . c o m cancer rates were above male rates in Denmark,

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Section: Lung Cancersupporting

confidence: 87%

Convergence of decreasing male and increasing female incidence rates in major tobacco-related cancers in Europe in 1988–2010

Lortet‐Tieulent

Rentería

Sharp³

et al. 2015

European Journal of Cancer

Self Cite

150

106

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“…Furthermore, despite the decrease in prevalence in some European countries, our country has shown a sustained increase [25]. On average, in our country breast cancer is diagnosed at a younger age (44.3 years) comparing with patients in other Eastern European countries such as Hungary (63.0 years), Croatia (55.8 years), Serbia (57.9 years), and Poland (44.5 years) [26]; additionally, Romania has the highest cancer mortality rate (30.9/100,000).…”

Section: Discussionmentioning

confidence: 89%

Qualitative strain elastography – strain ratio evaluation - an important tool in breast cancer diagnostic

et al. 2016

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Aims: To assess the quality of real time elastography as a differential diagnosis tool for breast nodules and to compare it with standard ultrasonography. Material and methods: In this prospective study we enrolled 174 patients in which 174 dominant breast nodules were considered for the final diagnosis. The results of ultrasonography and real time elastography, both qualitative and quantitative, were compared with pathology findings from the biopsy specimens. Results: Pathology examinations determined 102 nodules were benign and 72 malignant. Qualitative elastography had a better diagnostic performance (82.4% sensitivity and 81.9% specificity) than ultrasonography plus Doppler evaluation (70.3% sensitivity and 73.5% specificity). Quantitative elastography, assessed using the fat-to-lesion ratio, was a good discriminant for malignancy (AUROC = 0.93, p < 0.001). Our results pointed to an optimal threshold for malignancy of > 4.88; by using this threshold, the diagnostic reliability of the fat-to-lesion ratio was better than both ultrasonography and qualitative elastography (86.5% sensitivity and 90.4% specificity). Conclusion: Real time elastography is superior to ultrasonography in diagnosing malignant breast nodules. The evaluation of nodules using a fat-to-lesion ratio was a better discriminant for malignancy than qualitative elastography.

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“…There are significant differences in cancer incidence and mortality across Europe; the overall incidence is higher in Western European (WE) countries, whereas the mortality rate is higher in the Central and Eastern European (CEE) countries [2]. Furthermore, while cancer mortality has generally been decreasing in WE countries lately, this trend has not been observed in CEE countries [3][4][5][6]. Moreover, the incidence rates of several cancers in CEE countries have already reached the rates in WE or Nordic countries [2].…”

Section: Introductionmentioning

confidence: 99%

Cancer Control in Central and Eastern Europe: Current Situation and Recommendations for Improvement

et al. 2016

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The incidence of many cancers is higher in Western European (WE) countries, but mortality is frequently higher in Central and Eastern European (CEE) countries. A panel of oncology leaders from CEE countries participating in the South Eastern European Research Oncology Group (SEEROG) was formed in 2015, aiming to analyze the current status and trends of oncology care in CEE and to propose recommendations leading to improved care and outcomes. The SEEROG panel, meeting during the 11th Central European Oncology Congress, proposed the following: (a) national cancer control plans (NCCPs) required in all CEE countries, defining priorities in cancer care, including finance allocation considering limited health care budgets; (b) national cancer registries, describing in detail epidemiological trends; (c) efforts to strengthen comprehensive cancer centers; (d) that multidisciplinary care should be mandated by the NCCPs; (e) that smaller hospitals should be connected to multidisciplinary tumor boards via the Internet, providing access to specialized expertise; (f) nationwide primary prevention programs targeting smoking, obesity, and alcohol consumption and centrally evaluated secondary prevention programs for cervical, colorectal, and breast cancers; (g) prioritize education for all involved in cancer care, including oncology nurses, general practitioners, and palliative care providers; (h) establish outpatient care in day hospitals to reduce costs associated with the current inpatient model of care in CEE countries and to improve patients' quality of life; (i) long-term pharmacoeconomic evaluations of new therapies in CEE countries; (j) increase national oncology budgets in view of the higher mortality rates in CEE compared with WE countries; and (k) CEE countries urgently need help from the European Union to increase and monitor overall investment in cancer care.

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Cancer incidence and mortality patterns in South Eastern Europe in the last decade: Gaps persist compared with the rest of Europe

Cited by 68 publications

References 22 publications

Convergence of decreasing male and increasing female incidence rates in major tobacco-related cancers in Europe in 1988–2010

Convergence of decreasing male and increasing female incidence rates in major tobacco-related cancers in Europe in 1988–2010

Qualitative strain elastography – strain ratio evaluation - an important tool in breast cancer diagnostic

Cancer Control in Central and Eastern Europe: Current Situation and Recommendations for Improvement

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