Cancer Incidence and Survival in Kidney Transplant Patients

Native Nephrectomy for Renal Cell Carcinoma in Transplant Recipients

“…Potential risk factors they identified for solid organ malignancies included recipient age, duration of renal transplant, number of renal transplants, and use of tacrolimus. The duration of renal transplant, number of renal transplants, and use of tacrolimus all implicate immunosuppression as a major causative factor (16). The time between transplantation and detection of malignancy varied greatly among patient patients in our population, with the shorted period being 37 days and the longest being 14 years, with an average of approximately 3 years, thus many of our patients were transplanted with unknown malignancies.…”

Neoplasias urológicas de novo en pacientes trasplantados renales: experiencia en 1.751 pacientes

“…En los países occidentales el tumor de piel y el linfoma son las neoplasias más comunes en la población trasplantada 25,27 . Sin embargo, Vogt et al 28 , en un estudio de una población alemana trasplantada, no observan la alta incidencia de linfomas y cáncer de piel informados por otros grupos.…”

Novel Renal Transplant-Related Surgical Approaches in the 21st Century

“…(Berger et al, 2008;Steinberg et al, 2004) Long-term oncologic outcomes (overall, cancer-specific, and recurrence-free survivals) of laparoscopic radical nephrectomy, either with pure laparoscopic or HAD technique, or with trans-peritoneal or trans-retroperitoneal approach, for renal cell carcinoma (RCC) are comparable to those of its open counterpart, with the obvious benefits of less pain, less blood loss and earlier recuperation (Colombo et al, 2008;Chung et al, 2007;Venkatesh et al, 2007;Desai et al, 2005;Nambirajan et al, 2004). Patients with ESRD are known to have higher surgical risks (higher American Society of Anesthiologists score, higher comorbidity index, higher incidence of previous abdominal surgery, and higher incidence of hypertension), and yet they also have higher incidence of renal tumors and which does not decrease even after renal transplantation because of maintenance immunosuppression (Chueh SC et al, 2011a;Melchior et al, 2011;Navarro et al, 2008;Tollefson et al, 2010). Laparoscopic radical nephrectomy among this special patient group, even though more challenging and might be associated with slightly longer admission and higher perioperative risks, is well recognized as feasible and safe (Bird et al, 2010).…”

“…Kidney transplant recipients are at increased risk for malignancies (Chueh SC et al, 2011a;Navarro et al, 2008;Tollefson et al, 2010). Development of cancer depends on the duration and type of immunosuppression or association with viral infection.…”