Cancer incidence in a cohort of infertile women who underwent in vitro fertilization

Dor, Jehoshua; Lerner‐Geva, Liat; Rabinovici, Jaron; Chetrit, Angela; Levran, David; Lunenfeld, Bruno; Mashiach, Shlomo; Modan, Baruch

doi:10.1016/s0015-0282(01)02986-7

Cited by 140 publications

(115 citation statements)

References 27 publications

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“…In general, our results indicated that treatment with fertility drugs is not related to breast cancer risk, a result that is in line with the main findings from most previous studies (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)). An exception, however, was the finding of a f4-fold increased risk of ductal breast cancer after use of progesterone.…”

Section: Discussionsupporting

confidence: 92%

“…Results, thus far, have been contradicting, as most studies found no association between use of fertility drugs and risk of breast cancer (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), two studies found that fertility drugs increase the risk of breast cancer (23,24), whereas two other studies found that use of fertility drugs decrease the risk of developing breast cancer (25,26). Many of the previous studies have faced various methodologic limitations, for example, low statistical power due to a low number of breast cancer cases and inability to control for potential confounders.…”

Section: Introductionmentioning

confidence: 99%

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Risk of Breast Cancer After Exposure to Fertility Drugs: Results from a Large Danish Cohort Study

Jensen

Sharif

Svare

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Few epidemiologic studies have examined the association between fertility drugs and breast cancer risk, and results have been contradicting. Using data from the largest cohort of infertile women to date, the aim of this study was to examine the effects of fertility drugs on breast cancer risk overall and according to histologic subtypes. Method: A cohort of 54,362 women with infertility problems referred to all Danish fertility clinics between 1963 and 1998 was established. A detailed data collection, including information of type and amount of treatment, was conducted. We used case-cohort techniques to calculate rate ratios (RR) of breast cancer associated with use of five groups of fertility drugs, after adjustment for parity status. Results: Three hundred thirty-one invasive breast cancers were identified in the cohort during follow-up through 1998. Analyses within cohort showed no overall increased breast

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Risk of Breast Cancer After Exposure to Fertility Drugs: Results from a Large Danish Cohort Study

Jensen

Sharif

Svare

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Limitations of their studies included the relatively short periods of follow-up, with medians of %10 years and an inability to adjust for important breast cancer risk factors, including parity. Their results were confirmed in two later papers (13,14), but these were based on only a few breast cancer cases (n ¼ 11 and 4) and short periods of follow-up (mean follow-ups 3.6 and 6.5 years). In contrast, two other studies found a possible increase in the risk of breast cancer in those undergoing IVF, with those aged >40 years (15) and >30 years (16) at increased risk.…”

mentioning

confidence: 71%

In vitro fertilization and breast cancer: is there cause for concern?

Stewart

Holman

Hart

et al. 2012

Fertility and Sterility

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“…In 1082 women undergoing IVF, there was an increased rate of cancer in the first year after DOI:http://dx.doi.org/10.7314/APJCP.2013.14.11.6529 Very Young Breast Cancer in a Referral Center in Tehran, Iran;Review of 55 Cases Aged 25 or Less throughout 33 Years treatment but no increased risk afterwards (Lerner-Geva et al, 2003), and a large cohort of 5026 women undergoing in vitro fertilization (IVF), showed no excess risk for cancer (Dor et al, 2002). There was one case of infertility among our patients; this surely cannot disclose any special association between the two diseases.…”

Section: Discussionmentioning

confidence: 99%

Very Young Breast Cancer in a Referral Center in Tehran, Iran: Review of 55 Cases Aged 25 or Less throughout 33 Years

Alipour¹,

Omranipour²,

Jahanzad³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer is mostly the disease of postmenopausal women but very young affected women are seen more than occasionally in developing countries. We reviewed our cases of very young breast cancer in order to help in better understanding of such cases. Materials and Methods: The records of patients 25 years of age or less who had been admitted for breast cancer surgery in the Cancer Institute of Tehran from 1979 to 2012 were reviewed and relevant data were extracted. Results: From 5,265 cases of breast cancer, 62 patients had 25 years of age or less. There were 55 cases of breast adenocarcinoma, all female. More than 78% of the patients had presented with a palpable mass, the family history was positive in 2% of cases, and about 94% of the histologies were invasive ductal carcinoma. Gestational breast cancer constituted 10% of the cancers; another 10%were bilateral. The median size of the tumors was 5.72 centimeters, 63.2% of them had axillary lymphatic involvement, and more than half were negative for hormone receptors. Conclusions: Our study shows an incidence of 1.17% for very young breast cancer and a 10% rate of bilaterality which probably warrants special guidelines for contralateral screening. Cancer stage and features were poor in comparison with breast cancer in all ages.

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Cancer incidence in a cohort of infertile women who underwent in vitro fertilization

Cited by 140 publications

References 27 publications

Risk of Breast Cancer After Exposure to Fertility Drugs: Results from a Large Danish Cohort Study

Risk of Breast Cancer After Exposure to Fertility Drugs: Results from a Large Danish Cohort Study

In vitro fertilization and breast cancer: is there cause for concern?

Very Young Breast Cancer in a Referral Center in Tehran, Iran: Review of 55 Cases Aged 25 or Less throughout 33 Years

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