Cancer incidence in Behçet’s disease

Güven, Deniz Can; Bolek, E. C.; Altıntop, Sabri Engin; Çelikten, Burcu; Aktaş, Burak Yasin; Kiraz, Sedat; Güllü, İbrahi̇m; Karadağ, Ömer; Dizdar, Ömer

doi:10.1007/s11845-020-02244-0

Cited by 10 publications

(6 citation statements)

References 44 publications

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“…In another retrospective study published in 2020 (12), including Turkey data, 11 cancer cases (3 females, 8 males) were observed during a median follow-up of 124 months in 451 cases with BD. Of these, 10 were solid tumours and 1 was myelodysplastic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…The remaining agents, including glucocorticoids, methotrexate, azathioprine and cyclosporine did not significantly correlate with cancer risk. In a study published in 2020 (12), which includes data from Turkey, azathioprine was also found to reduce the risk of cancer. In the present study, there was no relationship between the treatments used and malignancy in BD and malignancy in the family.…”

Section: Wang Et Al (mentioning

confidence: 99%

“…BD has previously been associated with an increased risk of malignancy, both solid tumours and hematologic malignancies (4)(5)(6)(7)(8)(9). Common environmental triggers, altered immune system, genetic factors and long-term use of immunosuppressants may be responsible for development of malignancy in BD (10)(11)(12)(13). In addition to the role in BD pathogenesis, the HLA-B51 polymorphism has also been reported to be related with lymphoma, cervical carcinoma, papillary thyroid carcinoma (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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The relationship between malignancy and Behçet's disease features

Doğan

Armağan

Gök

et al. 2022

Journal of Health Sciences and Medicine

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Introduction: Behçet's disease (BD) is an autoimmune, multisystemic vasculitis characterized by chronic inflammation. Autoimmune responses in BD could drive chronic inflammation which is a risk for malignant transformation. Some genetic, environmental, clinical features and immunosuppressive treatments in BD may increase the risk of malignancy. Common genetic factors and similar environmental factors play a role in the pathogenesis of some autoimmune diseases and malignancies. We hypothesized that the frequency of comorbidity and clinical features of BD may differ in BD patients with a family history of malignancy. So, we aimed to compare the demographic and clinical characteristics features of the BD patients with and without a family history of malignancy. Material and Method:The BD patients who admitted the rheumatology outpatient clinic consecutively were included in the study. The demographic and clinical characteristics, comorbidities including malignancy in BD patients and malignancies in their family were questioned. The acute phase reactant elevation of at least two follow-ups was accepted as chronic inflammation.Results: A total of 98 patients (57% male) were included. Mean age was 43.5±12.3 years. The frequency of comorbidity was 60% and malignant/premalignant lesions were seen in 5% of the patients. All lesions were solid organ related and all of them were in women. History of BD and malignancy in patients' families was found 28% and 38%, respectively. The patients with and without malignancy in their family were compared. Female gender and the frequency of erythema nodosum were higher in the patients with malignancy in their family. The other demographic and clinical characteristics, chronic persistent inflammation and medical treatments were statistically. not different Conclusion: Frequency of malignancy in BD patients' family was evaluated and to the best of our knowledge, there was no literature data on this subject interestingly. The family history of malignancy in BD patients could be associated with clinical characteristics. Further prospective studies were needed to show the clinical effect of malignancy history in families.

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Section: Discussionmentioning

confidence: 99%

Section: Wang Et Al (mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationship between malignancy and Behçet's disease features

Doğan

Armağan

Gök

et al. 2022

Journal of Health Sciences and Medicine

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“…In a retrospective cohort study, Yeh et al observed that the risk of obstructive sleep apnoea was significantly increased among patients with BS as well as Sjögren's syndrome (64). Guven et al demonstrated an increased cancer risk in BS (65). A high frequency of sexual dysfunction in BS especially among those with neurological involvement was observed (66).…”

Section: Miscellaneous Conditionsmentioning

confidence: 99%

One year in review 2021: Behçet's syndrome

Hatemi

Seyahi

Fresko

et al. 2021

Clinical and Experimental Rheumatology

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This review aims to provide a critical digest of the recent studies that enhance our understanding of Behçet's syndrome by evaluating time trends, differences in disease course between men and women, and between patients with an early and late disease onset, progress in disease assessment, novel findings on immunopathogenesis and genetics, clinical features and differential diagnosis of eye, vascular, nervous system and gastrointestinal system involvement, and new data on treatment modalities including tofacitinib, and apremilast, as well as surgical interventions.

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“…Similar to other inflammatory diseases, BS has been recently associated with an increased risk of cardiovascular disease, thromboembolic disease, and mortality [ 101 ]. Recent studies have also implicated an overall increased risk of malignancy [ 102 – 104 ].…”

Section: Behçet Syndromementioning

confidence: 99%

Neutrophilic Dermatoses: a Clinical Update

Weiss

Leung

et al. 2022

Curr Derm Rep

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Purpose of Review Neutrophilic dermatoses are defined by the presence of a sterile neutrophilic infiltrate on histopathology. This review focuses on the pathogenesis, epidemiology, clinicopathological features, diagnosis, and management of four disorders: Sweet syndrome, pyoderma gangrenosum, Behçet syndrome, and neutrophilic eccrine hidradenitis.Recent Findings Recent studies have provided insight into the complex pathogenesis of neutrophilic dermatoses. Evidence supports an intricate interplay of abnormal neutrophil function and inflammasome activation, malignant transformation into dermal infiltrating neutrophils, and genetic predisposition. Summary Neutrophilic dermatoses have diverse cutaneous and extracutaneous manifestations and may be associated with significant morbidity and mortality. Common underlying associations include infectious, inflammatory, and neoplastic disorders, as well as drug reactions. Emerging diagnostic and therapeutic frameworks identify an expanding role for biologic and targeted anti-inflammatory therapies. KeywordsAcute febrile neutrophilic dermatosis • Behçet disease • Neutrophilic dermatosis • Neutrophilic eccrine hidradenitis • Pyoderma gangrenosum • Sweet syndrome This article is part of the Topical Collection on Hospital-Based Dermatology

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Cancer incidence in Behçet’s disease

Cited by 10 publications

References 44 publications

The relationship between malignancy and Behçet's disease features

The relationship between malignancy and Behçet's disease features

One year in review 2021: Behçet's syndrome

Neutrophilic Dermatoses: a Clinical Update

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