Cancer incidence in Conakry, Guinea: first results from the cancer registry 1992–1995

Koulibaly, M; Kabba, I S; Cissé, A; Diallo, S; Diallo, Mamadou Bobo; Keita, Namory; Camara, Naby Daouda; Diallo, Mamadou Sailou; Sylla, Bakary S.; Parkin, D. Maxwell

doi:10.1002/(sici)1097-0215(19970106)70:1<39::aid-ijc6>3.0.co;2-7

Cited by 64 publications

(43 citation statements)

References 26 publications

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“…Although younger subjects were underrepresented, such an age profile is comparable with other studies. The high cervical HPV infection prevalence and SIL are in agreement with Gambian Cancer Registry data (Koulibaly et al, 1997;Bah et al, 2001). Comparable prevalences of 14% have been observed in two cytologically normal populations in Senegal, the only nation on which The Gambia borders (Astori et al, 1999;Xi et al, 2003).…”

Section: Discussionsupporting

confidence: 86%

“…Cervical cancer is the most common malignancy in West African women (Koulibaly et al, 1997;Bah et al, 2001) but accurate, population-based HPV prevalence data are lacking. Many therapeutic and prophylactic vaccines against HPV infection are in development, with some now entering phase III trials Nardelli-Haefliger et al, 2003;Taira, 2004;Tomson et al, 2004;Christensen, 2005;Gravitt and Shah, 2005;Maclean et al, 2005).…”

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confidence: 99%

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Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology

et al. 2005

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The development of effective strategies against cervical cancer in Africa requires accurate type specific data on human papillomavirus (HPV) prevalence, including determination of DNA sequences in order to maximise local vaccine efficacy. We have investigated cervical HPV infection and squamous intraepithelial lesions (SIL) in an unselected cohort of 1061 women in a rural Gambian community. Squamous intraepithelial lesions was diagnosed using cytology and histology, HPV was typed by PCR-ELISA of DNA extracts, which were also DNA sequenced. The prevalence of cervical HPV infection was 13% and SIL were observed in 7% of subjects. Human papillomavirus-16 was most prevalent and most strongly associated with SIL. Also common were HPV-18, -33, -58 and, notably, -35. Human papillomavirus DNA sequencing revealed HPV-16 samples to be exclusively African type 1 (Af1). Subjects of the Wolof ethnic group had a lower prevalence of HPV infection while subjects aged 25 -44 years had a higher prevalence of cervical precancer than older or younger subjects. This first report of HPV prevalence in an unselected, unscreened rural population confirms high rates of SIL and HPV infection in West Africa. This study has implications for the vaccination of Gambian and other African populations in the prevention of cervical cancer.

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Section: Discussionsupporting

confidence: 86%

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confidence: 99%

Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology

et al. 2005

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“…The 50 articles considered irrelevant did not comply with the exclusion/inclusion criteria set for this review; however, some were retained for extra information, mainly in the discussion. The 15 relevant articles [10,20,[32][33][34][35][36][37][38][39][40][41][42] were then supplemented by the 21 data sets secured with permission from the IARC [43,44] and the further 21 data sets which were received from the directors of the cancer registries through the IACR [16]. Six articles, which were not suitable for contribution to the estimates of incidence but were sourced for full-text copies, were retained for information on the biological characteristics of CRC diagnosed in SSA.…”

Section: Search Strategy For Systematic Analysis and Data Extractionmentioning

confidence: 99%

Estimating the incidence of colorectal cancer in Sub–Saharan Africa: A systematic analysis

Graham¹,

Rudan²,

Grant³

et al. 2012

J Glob Health

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“…The country shows high birth rates (5.8 children per woman) and communicable diseases, notably malaria, which predominate as causes of death. Estimates of cervical cancer incidence and mortality rates in western Africa are among the highest in the world (Ferlay et al, 2004), and in Conakry, cervical cancer is by far the most common malignancy in women (Koulibaly et al, 1997).…”

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confidence: 99%

HPV infection in women with and without cervical cancer in Conakry, Guinea

et al. 2009

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BACKGROUND: Cervical cancer incidence in western Africa is among the highest in the world. METHODS: To investigate human papillomavirus (HPV) infection in Guinea, we obtained cervical specimens from 831 women aged 18 -64 years from the general population of the capital Conakry and from 77 locally diagnosed invasive cervical cancers (ICC). Human papillomavirus was detected using a GP5 þ /6 þ PCR-based assay. RESULTS: Among the general population, the prevalence of cervical abnormalities was 2.6% by visual inspection and 9.5% by liquidbased cytology. Fourteen of 15 high-grade squamous intraepithelial lesions were visual inspection-negative. Human papillomavirus prevalence was 50.8% (32.1% for high-risk types) and relatively constant across all age groups. Being single or reporting X3 sexual partners was significantly associated with HPV positivity. HPV16 was the most common type, both among the general population (7.3%) and, notably in ICC (48.6%). HPV45 (18.6%) and HPV18 (14.3%), the next most common types in ICC, were also more common in ICC than in HPV-positive women with normal cytology from the general population. CONCLUSION: The heavy burden of HPV infection and severe cervical lesions in Guinean women calls for new effective interventions. Sixty-three per cent of cervical cancers are theoretically preventable by HPV16/18 vaccines in Guinea; perhaps more if some cross-protection exists with HPV45.

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Cancer incidence in Conakry, Guinea: first results from the cancer registry 1992–1995

Cited by 64 publications

References 26 publications

Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology

Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology

Estimating the incidence of colorectal cancer in Sub–Saharan Africa: A systematic analysis

HPV infection in women with and without cervical cancer in Conakry, Guinea

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