Cancer Incidence in Systemic Sclerosis: Meta‐Analysis of Population‐Based Cohort Studies

Ōnishi, Akira; Sugiyama, Daisuke; Kumagai, Shunichi; Morinobu, Akio

doi:10.1002/art.37969

Cited by 164 publications

(150 citation statements)

References 44 publications

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“…In many cohort, prospective, retrospective, and case control studies, hematological cancers such as non-Hodgkin lymphoma, leukaemia, multiple myeloma, and myeloproliferative neoplasms were reported in patients with SSc (3-6). A 2.5-fold increased risk for hematological cancers in a nationwide population-based cohort study was reported by Olesen et al (8) Paraneoplastic scleroderma may accompany hematologic malignancies (3,4). An increased risk for non-Hodgkin lymphoma was reported in female patients with SSc (1).…”

Section: Case Presentationmentioning

confidence: 88%

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Refractory anemia in systemic sclerosis: myelodisplastic syndrome

2015

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Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by small vessel vasculopathy, autoantibodies, and skin or visceral organ fibrosis (lung, oesophagus, kidney etc.) as a result of extracellular collagen deposition. The cancer risk is higher in many rheumatic diseases, including SSc. Various defined malignancies may develop in 3%-11% of patients with SSc. These solid tumors are generally observed in the lung, oesophagus, or breast. In addition, an increased risk for hematological cancers were reported in literature. Herein, we describe an interesting case of SSc complicated by myelodisplastic syndrome (MDS). Our aim is to draw attention to developing cancers and the rare occurence of MDS in patients with SSc.

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Section: Case Presentationmentioning

confidence: 88%

“…In addition, the risk for hematological cancers has a lower frequency than solid tumors in SSc. (2)(3)(4). The occurence of myelodisplastic syndrome (MDS) secondary to SSc is rarely reported in literature (5,6).…”

Section: Introductionmentioning

confidence: 99%

Refractory anemia in systemic sclerosis: myelodisplastic syndrome

2015

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“…Malignancy associated with systemic scleroderma has been described as a direct consequence of fibrosing process involving internal organ as well as an origin of paraneoplastic manifestation predominately linked with lung cancer, liver cancer, urinary tract or malignant hematologic disorders (3,4). Up to date, several studies have pointed at sudden development of morphea before or in brief time interval after the diagnosis of malignancy.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Paraneoplastic Manifestation (Morphea, Lichen Sclerosus) – Two Case Reports

Pappova

Kozárová

et al. 2017

Acta Medica Martiniana

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A b s t r a c tInternal malignancy may be presented in the form of paraneoplastic syndromes, which may indicate either formation or recurrence of a previously treated malignancy. Furthermore cutaneous paraneoplastic disorders often precede a diagnosis of cancer. We present 2 unique case reports with cutaneous paraneoplastic manifestations. The first one describes a patient with sudden progression of long-term stabilized morphea in connection with newly diagnosed hepatocellular carcinoma (HCC). The second one describes female patient with breast cancer preceded by the development of extragenital lichen sclerosus (LS) with typical sclerotic lesions and hemorrhagic bullae.

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“…A comparison with other experiences performed in other countries regarding age-related cancer screening procedures was not feasible on the grounds of the different local guidelines. Recently, two meta-analyses were published about cancer incidence among SSc patients (27,28). The relative risk to develop all invasive cancer was quantified in 1.75 (27).…”

Section: N Discussion and Conclusionmentioning

confidence: 99%

“…The relative risk to develop all invasive cancer was quantified in 1.75 (27). SSc men were more prone than women to develop neoplastic diseases (28). The results for selected cancers showed that SSc patients have in comparison with the general population a higher risk of developing lung and haematological neoplasms (27,28), as well liver and bladder cancers (28).…”

Section: N Discussion and Conclusionmentioning

confidence: 99%

Adherence to recommendations for cervical and breast cancer screening in systemic sclerosis

et al. 2015

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In Italy, the current recommendations for the early diagnosis of the most frequent female cancers suggest screening women aged 25-64 years for cervical cancer with Papanicolaou (Pap) test at 3-year intervals and women aged 50-69 years at 2-year interval with mammography (1). The aim of cancer screening is to detect precancerous lesions or early neoplastic transformation, thereby resorting to earlier and potentially less invasive treatment than what is required for symptomatic and more advanced cancers. The benefit of cancer screening procedures in terms of lower incidence of the invasive disease and lower mortality has extensively been documented (2-5). There are discordant data regarding adherence to cancer screening programs in patients affected by systemic lupus erythematosus (SLE). A Canadian study showed that 53% of 48 SLE women aged 50-69 and 33% of 27 SLE women aged less than 30 years reported to have performed a mammogram and a Pap test, in the previous year. These figures compare with 74% and 56% of similarly aged control women, respectively. Moreover, among 51 SLE subjects aged 50 and older, only 18% reported screening for colorectal cancer compared to 48% in the general population. Non-white SLE patients, those with lower educational level, and with higher disease damage scores were less likely to undergo cervical Pap testing (6). It is not clear why SLE women are less careful in performing age-related cancer screening in agreement with recommendations. These results might be attributed to the tedious-SUMMARY The aim of the study was to evaluate the adherence of systemic sclerosis (SSc) female patients to cervix and breast cancer screening procedures, as suggested by local guidelines. A cohort of 84 SSc women was asked if they had undergone mammography and Pap test during the previous 2-and 3-year intervals, as indicated according to the Italian recommendations. The results were compared with those collected in patients affected by other chronic rheumatic disorders and in the general population. More than 85% of SSc women declared to comply with an age-related cervix and breast cancer screening schedule. The data were similar to those collected in patients affected by other chronic rheumatic disorders, whereas the subjects belonging to the general population reported to undergo breast cancer screening more frequently. Among SSc women, neither the educational level, nor the lung and skin involvement influenced their cancer screening program compliance. Only a positive history of ischemic digital ulcers seemed to interfere with mammography. Our study reported a very high percentage of SSc female patients who adhered to programs for the early detection of cervical and breast cancer. The significant adherence to guidelines may be due to the schedule adopted by the local health public service, which regularly invites eligible subjects by mail to undergo cancer screening at no charge.

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Cancer Incidence in Systemic Sclerosis: Meta‐Analysis of Population‐Based Cohort Studies

Cited by 164 publications

References 44 publications

Refractory anemia in systemic sclerosis: myelodisplastic syndrome

Refractory anemia in systemic sclerosis: myelodisplastic syndrome

Cutaneous Paraneoplastic Manifestation (Morphea, Lichen Sclerosus) – Two Case Reports

Adherence to recommendations for cervical and breast cancer screening in systemic sclerosis

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