Cancer incidence in western region of Libya: Report of the year 2009 from tripoli pathology-based cancer registry

Elzouki, Islam; Benyasaad, Taha; Altrjoman, Firyous; Elmarghani, Ahmad; Abubaker, Kamal; Elzagheid, Adam

doi:10.4103/ljms.ljms_17_18

Cited by 8 publications

(4 citation statements)

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“…The second most occurred type of cancer was colorectal cancer which was more diagnosed in men. In contrast, the previous analyses of the BMC data in 2003 (8) , and the Western study in 2009 (6) found that lung cancer was the most frequent among men. As such, colorectal cancer was the most common cancer in men in Tubrok's study (7) .…”

Section: Discussionmentioning

confidence: 67%

“…Moreover, our results found a slightly higher number of women with cancer compared with men. Whereas, and the Western study in 2009 (6) found higher cancer incidence rates in men than in women. This study has several limitations, being cross-sectional based on a retrospective review of a systematic sample of patient files may affect the validity and generalizability of results.…”

Section: Discussionmentioning

confidence: 85%

“…lung cancer was common in men, and breast cancer in women in the Western region. [6] A study from Tobruk in the Eastern region [7] found Breast and uterine cancers were the most common cancers in women, and bladder and colorectal cancer were the most common cancers in men, followed by colorectal cancer in both genders. A previous study [8] from the BMC indicated that lung cancer and colorectal cancer followed by cancers of the head, neck, and bladder were the most frequently diagnosed malignancies in males Among females, they were breast cancer, cancer of the colon and rectum, uterus, and non-Hodgkin lymphoma.…”

Section: Introductionmentioning

confidence: 99%

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Cancer Patterns among Patients Admitted to the Oncology Department at Benghazi Medical Center, Libya (2013-2017)

Hussein,

Omar

2023

JMAHS

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Background: Cancer is a major public health problem that faces health managers and decision-makers in many countries. Cancer is constantly growing and is one of the major causes of mortality in Libya. Aim: To estimate the geographical distribution and patterns of cancer among patients admitted to the Oncology Department at Benghazi Medical Center (BMC). Methods: A retrospective cross-sectional study was conducted from March to April 2019. A total of 4649 patients’ files with a diagnosis of cancer at the BMC were extracted as hard copies due to the absence of electronic medical files. A sampling approach was performed to facilitate the analyses. The sample size was (206) files out of (4649) files, which was determined via a statistical software program (Epi Info7) Data was collected retrospectively from patients’ files; on age, gender, address, and classification of the cancer diagnosis which was made according to (ICD–Oncology) for a specific period (5 years – from January 1st, 2013 to December 31st, 2017). Results: The results revealed that more than half of the cancer cases admitted to Benghazi Medical Center were from Benghazi City and (52.4%) of cases were females whereas (47.6%) were males, (18.9 %) were (<40y), (49.5 %) were between (40 to 65y), and (31.6%) were > 65y. The most common cancers among females were breast cancer (28.6%) and endometrial cancer (7.3%), whereas among males were colorectal cancer (8.3%), prostate cancer (6.8%), gastrointestinal (6.3%) and lung cancer (6.3%). Conclusion: The most common cancer among women was breast cancer and among men was colorectal and prostate cancer. The majority of cases were from Benghazi. Further studies are required to confirm such results. Educating people about the risk factors that could increase cancer incidence, especially lifestyle, and dietary patterns.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Cancer Patterns among Patients Admitted to the Oncology Department at Benghazi Medical Center, Libya (2013-2017)

Hussein,

Omar

2023

JMAHS

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“…The most common cancer of women in Libya is breast cancer (20.6%) (Elzouki et al , 2018). Most Libyan patients present with advanced disease and are often younger than in Europe, in line with the pattern common in North Africa (Boder et al , 2011).…”

Section: Introductionmentioning

confidence: 99%

Investigation of BRCA1 exon 11 genetic variations in breast cancer among Libyan women

Elshwekh,

Alhudiri,

Abdul Jalil

et al. 2023

Preprint

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Introduction The majority of hereditary breast and ovarian cancers are associated with mutations in two genes, breast cancer type 1 and 2 susceptibility genes (BRCA1 and BRCA2). Here, we describe for the first time analysis of BRCA1 exon 11 in 48 Libyan breast cancer patients with a family history of cancer. Methods All patients had a family history of cancer and were included in the study only if they have a family history of breast or ovarian cancer, male breast cancer, or triple negative tumors. PCR was performed using specific primer pairs spanning BRCA1 exon 11 followed by Sanger sequencing. Genetic analysis was done using Sequencher 5.1. Results We identified 12 genetic variants in BRCA1 exon 11. Three variants were novel (c.1019T>C, c.2363T>G, and c.3192T>C). c.2363T>G was predicted by SIFT as damaging. Six variants were of unknown significance (c.918T>C, c.1853G>C, c.1886G>A, c.2215A>G, c.2612C>T, c.3113A>C and c.3784T>C), and 3 were classified as benign in ClinVar database (c.918T>C, c.2082C>T and c.2311T>C). Conclusions Scanning of the entire BRCA1 is needed to identify any associated deleterious mutations. Although the clinical importance of unclassified variants is unknown, the association of certain variants with deleterious mutations and contralateral breast cancer warrants genetic testing and counseling in the Libyan population.

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Factors Associated with Recurrence of Breast Cancer Using Cox Proportional Hazard Model

Ashleik,

Shembesh,

Saad

et al. 2023

2023 IEEE 11th International Conference on Systems and Control (ICSC)

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Cancer incidence in western region of Libya: Report of the year 2009 from tripoli pathology-based cancer registry

Cited by 8 publications

References 0 publications

Cancer Patterns among Patients Admitted to the Oncology Department at Benghazi Medical Center, Libya (2013-2017)

Cancer Patterns among Patients Admitted to the Oncology Department at Benghazi Medical Center, Libya (2013-2017)

Investigation of BRCA1 exon 11 genetic variations in breast cancer among Libyan women

Factors Associated with Recurrence of Breast Cancer Using Cox Proportional Hazard Model

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