Cancer Incidence of Schizophrenic Patients Results of Record Linkage Studies in Three Countries

Gulbinat, W.; Dupont, Annelise; Jablensky, Assen; Jensen, Ole Møller; Marsella, Anthony J.; Nakane, Yoshibimi; Sartorius, Norman

doi:10.1192/s0007125000297080

Cited by 98 publications

(85 citation statements)

References 24 publications

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“…As mentioned in the introduction, APO-SUS rats share several characteristics with patients who suffer from schizophrenia (24,(26)(27)(28)(29)(30)(31)39), and there are studies showing that the incidence of cancer is reduced in these patients (18,19). The reduced angiogenic response and the associated reduction in tumor growth or metastasis formation in APO-SUS rats suggest that the APO-SUS rat is a valuable tool in the search for the contribution of genetic and environmental stimuli to the apparent protection of patients with schizophrenia from cancer.…”

Section: Discussionmentioning

confidence: 99%

Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system

et al. 2002

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Outgrowth of solid tumors requires blood supply to the tumor. Tumor angiogenesis is dependent on the interplay between tumor-derived angiogenic factors and stromal cells. Recently, it has been shown that the neurotransmitter dopamine is a potent inhibitor of VEGF-induced angiogenesis. Moreover, there is evidence that patients with schizophrenia have a hyperreactive dopaminergic system and are relatively protected from cancer. We hypothesized that hyperreactivity of the dopaminergic system is related to reduced angiogenesis and tumor development. Therefore, we investigated tumor growth and angiogenesis in two lines of Wistar rats with high (APO-SUS) or low (APO-UNSUS) dopaminergic reactivity. Subcutaneous implants of mammary adenocarcinoma cells (MADB106) in matrigel remained 35% smaller in APO-SUS rats than in APO-UNSUS rats (P<0.01). Moreover, APO-SUS rats developed less lung metastases after i.v. administration of MADB106 tumor cells. Furthermore, hemoglobin content (APO-SUS: 40.6+/-7.6; APO-UNSUS: 76.9+/-13 mg/dl, P<0.05) and expression of the endothelial determinant PECAM-1 in tumors from APO-SUS rats were reduced (APO-SUS: 37+/-18; APO-UNSUS 69+/-25 units, P<0.01), indicating that reduced angiogenesis is responsible for reduced tumor development in APO-SUS rats. These results suggest a novel link between dopaminergic reactivity, angiogenesis, and tumor development and may explain part of the individual differences in cancer progression.

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Section: Discussionmentioning

confidence: 99%

Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system

et al. 2002

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“…Although some studies have found that cancer risk in patients with schizophrenia was higher relative to the general population, others have found either lower cancer risk or no difference . In general, findings vary greatly with regard to the direction and size of the difference according to tumor sites, study sites, racial and/or ethnic groups, and populations …”

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confidence: 95%

“…(9) In general, findings vary greatly with regard to the direction and size of the difference according to tumor sites, (10) study sites, racial and ⁄ or ethnic groups, and populations. (11) Several hypotheses have been proposed to explain the differential cancer risk in the schizophrenic population. Patients with schizophrenia may appear to have lower risk because they are less likely to be screened for cancer, due to their more limited access to health care.…”

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confidence: 99%

Inverse association between cancer risks and age in schizophrenic patients: A 12‐year nationwide cohort study

et al. 2013

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The association between schizophrenia and cancer risk is contentious in the clinical and epidemiological literature. Studies from different populations, tumor sites, or health care systems have provided inconsistent findings. In the present study, we examined a less well-investigated hypothesis that age plays a crucial role in cancer risk in schizophrenia. We conducted a nationwide cohort study using Taiwan In contrast, cancer risks were higher for cancers that have a younger age of onset, such as cancers of the nasopharynx (SIR = 1.18; 95% CI 1.08-1.49), breast (SIR = 1.50; 95% CI 1.44-1.66) and uterine corpus (SIR = 2.15; 95% CI 1.98-2.74). The unique age structures and early aging potential of schizophrenia populations may contribute to the observed inverse relationship between age and cancer risk. Higher cancer comorbidity in young schizophrenic patients deserves more attention. (Cancer Sci 2013; 104: 383-390)

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“…[4][5][6][7][8][9][10][11][12] They may be disadvantaged physically, psychologically, and socially. Patients with psychotic illnesses, particularly schizophrenia, may be most severely affected.…”

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confidence: 99%

Uptake of screening for breast cancer in patients with mental health problems

Werneke

Horn²,

Maryon‐Davis³

et al. 2006

Journal of Epidemiology & Community Health

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Cancer Incidence of Schizophrenic Patients Results of Record Linkage Studies in Three Countries

Cited by 98 publications

References 24 publications

Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system

Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system

Inverse association between cancer risks and age in schizophrenic patients: A 12‐year nationwide cohort study

Uptake of screening for breast cancer in patients with mental health problems

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