Cancer incidence within a cohort occupationally exposed to asbestos: a study of dose–response relationships

Clin, Bénédicte; Morlais, Fabrice; Launoy, Guy; Guizard, Anne‐Valérie; Dubois, Brice; Bouvier, Véronique; Desoubeaux, Nelly; Marquignon, Marie-France; Raffaelli, C; Paris, Christophe; Galateau-Salle, Françoise; Guittet, Lydia; Letourneux, M.

doi:10.1136/oem.2010.059790

Cited by 29 publications

(24 citation statements)

References 24 publications

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“…Later on, a systematic review showed that none of the various methods used to estimate asbestos exposure yielded consistent exposure–response trends and the strength of the associations was consistently weak or non-existent for four forms of gastrointestinal cancers 3. However, recent studies conducted in a French cohort suggested a positive relationship with colorectal, small intestine and oesophageal cancer 4 5. An earlier literature review also showed that a high level of asbestos exposure, as indicated by a standardised mortality ratio (SMR) for lung cancer of at least 2.0, was associated with elevated SMR for gastrointestinal cancer 6.…”

Section: Introductionmentioning

confidence: 99%

Exposure to chrysotile mining dust and digestive cancer mortality in a Chinese miner/miller cohort

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Exposure to chrysotile mining dust and digestive cancer mortality in a Chinese miner/miller cohort

et al. 2014

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“…The most established occupational risk factor for colon cancer is physical inactivity, 39 which certainly does not characterize chimney sweeping. Some studies suggest an association with asbestos exposure, 40 whereas the effect of diet, alcohol, and tobacco is weak and under debate. 41 Occupational asbestos exposure seems to be the most likely explanation if this cancer is work related, although the chimney sweeps' exposure to asbestos was only moderate.…”

Section: Colon Cancermentioning

confidence: 99%

Cancer Incidence in a Cohort of Swedish Chimney Sweeps, 1958–2006

Hogstedt

Jansson²,

Hugosson³

et al. 2013

Am J Public Health

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Objectives. We examined cancer incidence in an expanded cohort of Swedish chimney sweeps. Methods. We added male chimney sweep trade union members (1981–2006) to an earlier cohort (employed 1918–1980) and linked them to nationwide registers of cancer, causes of deaths, and total population. The total cohort (n = 6320) was followed from 1958 through 2006. We estimated standardized incidence ratios (SIRs) using the male Swedish population as reference. We estimated exposure as years of employment and analyzed for exposure–response associations by Poisson regression. Results. A total of 813 primary cancers were observed versus 626 expected (SIR = 1.30; 95% confidence interval = 1.21, 1.39). As in a previous follow-up, SIRs were significantly increased for cancer of the esophagus, liver, lung, bladder, and all hematopoietic cancer. New findings included significantly elevated SIRs for cancer of the colon, pleura, adenocarcinoma of the lung, and at unspecified sites. Total cancer and bladder cancer demonstrated positive exposure–response associations. Conclusions. Exposure to soot and asbestos are likely causes of the observed cancer excesses, with contributions from adverse lifestyle factors. Preventive actions to control work exposures and promote healthier lifestyles are an important priority.

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“…Despite these differences in environmental exposure, asbestos-related stomach cancer following occupational exposure is the best validated to date [10,33–35,52–55]. Recently, asbestos exposure is linked with colorectal cancer in 285 cases of cancers while confirming the established relationship between asbestos exposure and pleuropulmonary and peritoneal cancers [56]. Some studies have concluded that a positive association may exist between asbestos exposure and GI cancer [41,44,56–61].…”

Section: Epidemiological Evidence: Gastrointestinal Cancers With Asbementioning

confidence: 97%

Asbestos-Induced Gastrointestinal Cancer: An Update

Kim

Williams

Cheresh

et al. 2013

J Gastrointest Dig Syst

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Asbestos-related diseases, such as malignancies and asbestosis, remain a significant occupational and public health concern. Asbestos is still widely used in many developing countries despite being a recognized carcinogen that has been banned over 50 countries. The prevalence and mortality from asbestos-related diseases continue to pose challenges worldwide. Many countries are now experiencing an epidemic of asbestos-related disease that is the legacy of occupational exposure during the 20th century because of the long latency period (up to 40 years) between initial asbestos exposure and exhibition of disease. However, the gastrointestinal (GI) cancers resulting from asbestos exposure are not as clearly defined. In this review, we summarize some of the recent epidemiology of asbestos-related diseases and then focus on the evidence implicating asbestos in causing GI malignancies. We also briefly review the important new pathogenic information that has emerged over the past several years that may account for asbestos-related gastrointestinal cancers. All types of asbestos fibers have been implicated in the mortality and morbidity from GI malignancies but the collective evidence to date is mixed. Although the molecular basis of GI cancers arising from asbestos exposure is unclear, there have been significant advances in our understanding of mesothelioma and asbestosis that may contribute to the pathophysiology underlying asbestos-induced GI cancers. The emerging new evidence into the pathogenesis of asbestos toxicity is providing insights into the molecular basis for developing novel therapeutic strategies for asbestos-related diseases in future management.

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Cancer incidence within a cohort occupationally exposed to asbestos: a study of dose–response relationships

Abstract: While confirming the established relationship between asbestos exposure and pleuropulmonary and peritoneal cancers, this study also suggests a causal relationship between asbestos exposure and colorectal cancer.

Cited by 29 publications

References 24 publications

Exposure to chrysotile mining dust and digestive cancer mortality in a Chinese miner/miller cohort

Exposure to chrysotile mining dust and digestive cancer mortality in a Chinese miner/miller cohort

Cancer Incidence in a Cohort of Swedish Chimney Sweeps, 1958–2006

Asbestos-Induced Gastrointestinal Cancer: An Update

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