Cancer-Induced Bone Pain Management Through Buddhist Beliefs

Cheng, Fung Kei

doi:10.1007/s10943-017-0401-5

Cited by 8 publications

(4 citation statements)

References 96 publications

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“…Patients in hospice care who volunteered to practice Buddhist wisdom were found to have a decreased fear of death 38 . The same was found for a bone cancer patient 39 .…”

Section: The Association Between Nonself Desire and Death Anxiety: Fr...supporting

confidence: 79%

Death anxiety as mediator of relationship between renunciation of desire and mental health as predicted by Nonself Theory

Kuo

Chang

Lin

et al. 2022

Sci Rep

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In the present paper, we report two studies examining the relationships among renunciation of desires, death anxiety, and mental health. In the first study, we constructed the Desire Questionnaire (DQ), which measures success in renouncing certain desire. The DQ has satisfactory psychometric properties. In the second study, 501 adults from a Chinese society ranging in age from 17 to 84 years (M = 35.58, SD = 14.76) completed the DQ, the Death Anxiety Scale (DAS), and the Chinese Health Questionnaire (CHQ), which measures mental health and the presence of psychiatric symptoms. As predicted, DQ had significant negative correlations with both DAS (p < 0.05) and CHQ (p < 0.01). DAS had a significant positive correlation with CHQ (p < 0.01). In the linear mediation model, DAS was found to partially mediate the relationship between DQ and CHQ (β = − 0.18, p < 0.001). These results suggest that the negative effect of poor control of desires on mental health can be partially accounted for by death anxiety. These findings imply that training in eliminating desires can be a successful strategy to improve mental health. These results also support the Nonself Theory as a theory of death anxiety and show its relevance to the relationship between nonself and mental health.

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“…Patients in hospice care who volunteered to practice Buddhist wisdom were found to have a decreased fear of death 38 . The same was found for a bone cancer patient 39 .…”

Section: The Association Between Nonself Desire and Death Anxiety: Fr...supporting

confidence: 79%

Death anxiety as mediator of relationship between renunciation of desire and mental health as predicted by Nonself Theory

Kuo

Chang

Lin

et al. 2022

Sci Rep

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“…CIBP is a most difficult pain condition [ 22 ]. It is estimated that approximately 60–84% of cancer patients are suffering from different degrees of bone pain [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway

Tang

Chen

Yang

et al. 2022

BMC Musculoskelet Disord

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Objective Cancer-induced bone pain (CIBP) is a kind of pain with complex pathophysiology. Proteinase-activated receptor 2 (PAR-2) is involved in CIBP. This study explored the effects of PAR-2 on CIBP rats. Methods CIBP rat model was established by injecting Walker 256 rat breast cancer cells into the left tibia of female Sprague-Dawley rats and verified by tibial morphology observation, HE staining, and mechanical hyperalgesia assay. CIBP rats were injected with PAR-2 inhibitor, ERK activator, and CREB inhibitor through the spinal cord sheath on the 13th day after operation. CIBP behaviors were measured by mechanical hyperalgesia assay. On the 14th day after operation, L4-5 spinal cord tissues were obtained. PAR-2 expression, co-expression of PAR-2 and astrocyte marker GFAP, GFAP mRNA and protein levels and the ERK pathway-related protein levels were detected by Western blot, immunofluorescence double staining, RT-qPCR, and Western blot. Results CIBP rats had obvious mechanical hyperalgesia and thermal hyperalgesia from the 7th day after modeling; mechanical hyperalgesia threshold and thermal threshold were decreased; PAR-2 was increased in spinal cord tissues and was co-expressed with GFAP. PAR-2 silencing alleviated rat CIBP by inhibiting astrocyte activation. p-ERK/t-ERK and p-CREB/t-CREB levels in CIBP spinal cord were elevated, the ERK/CREB pathway was activated, while the ERK/CREB pathway was inhibited by PAR-2 silencing. The alleviating effect of PAR-2 inhibitor on hyperalgesia behaviors in CIBP rats were weakened by ERK activator, while were partially restored by CREB inhibitor. Conclusions PAR-2 knockdown inhibited the ERK/CREB pathway activation and astrocyte activation, thus alleviating CIBP in rats.

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“…Buddhism has lower POF level than non-believers, positive religious coping styles in Buddhists' life signi ed an internalized secure spiritual relationship and well-integrated copying resources on which they could rely across a variety of stress situations [49] . Previous study have shown Buddhist beliefs could treat bone pain caused by cancer in a study conducted in Hong Kong, we infer that the Buddhists may also turn to their faith for coping using private prayer, meditation, or Chanting when facing uncontrollable fatigue related to endoscopy [50] .…”

Section: Discussionmentioning

confidence: 82%

Developing a nomogram for predicting patients’ 24h-fatigue after digestive endoscopy with anesthesia assistance: a cross-sectional study

Wu,

Fang,

Jia

et al. 2024

Preprint

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Background Postoperative fatigue (POF) widely exists in patients underwent digestive endoscopy under anesthesia, seriously affecting patients’ postoperative rehabilitation and quality of life, there is few predicted tools for POF. We aim to identify predictors of 24 hours-postoperative fatigue (24h-POF) in patients underwent digestive endoscopy with anesthesia assistance and develop a nomogram. Methods This cross-sectional study involved 1306 patients underwent digestive endoscopy in The Second Affiliated Hospital Zhejiang University School of Medicine from May to November in 2023. Christensen Fatigue Scale was used to evaluate POF. Multiple linear regression analysis was utilized to ascertain independent predictors, and a nomogram was developed based on these findings. The area under the curve (AUC), calibration curve and decision curve analysis (DCA) were employed to evaluate the predictive model’s performance. Results 528 patients (40.43%) reported experiencing 24h-POF. Five modifiable factors (preoperative anxiety, average dosage of propofol, change rates of heart rate, fatigue 30 min after endoscopy, intraoperative hypotension) and nine non-modifiable factors (age, gender, drinker, numbers of comorbidities, degree of education, marital, Buddhist, endoscopic treatment, intraoperative tracheal intubation) were independently associated with 24h-POF in patients undergoing digestive endoscopy. The model exhibited good discrimination with an AUC of 0.865 and 0.891 in training cohort and validation cohort, respectively. The calibration curves and DCA curves demonstrated excellent calibration and clinical practicability. Conclusion The nomogram can effectively predict 24h-POF of digestive endoscopic patients, providing valuable assistance for early intervention to expedite patient recovery.

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Cancer-Induced Bone Pain Management Through Buddhist Beliefs

Cited by 8 publications

References 96 publications

Death anxiety as mediator of relationship between renunciation of desire and mental health as predicted by Nonself Theory

Death anxiety as mediator of relationship between renunciation of desire and mental health as predicted by Nonself Theory

Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway

Developing a nomogram for predicting patients’ 24h-fatigue after digestive endoscopy with anesthesia assistance: a cross-sectional study

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