Cancer Induction in Hamsters by Human Type 12 Adenovirus. Effect of Age and of Virus Dose.

Yabe, Yoshiro; Trentin, John J.; Taylor, Grant

doi:10.3181/00379727-111-27786

Cited by 47 publications

(24 citation statements)

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“…For instance, HAdV subgroup A types, such as HAdV type 12, are highly oncogenic [28][29][30] with the ability to induce tumors in new born rodents within 4 months. On the other hand, HAdV subgroup B are weakly oncogenic, and fi nally HAdV subgroups C, E, and F are not known to be oncogenic.…”

Section: Adenovirus: Biology Classification and Associated Diseasesmentioning

confidence: 99%

Human adenovirus: Viral pathogen with increasing importance

Ghebremedhin¹

2014

European Journal of Microbiology and Immunology

292

242

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The aim of this review is to describe the biology of human adenovirus (HAdV), the clinical and epidemiological characteristics of adenoviral epidemic keratoconjunctivitis and to present a practical update on its diagnosis, treatment, and prophylaxis. There are two well-defined adenoviral keratoconjunctivitis clinical syndromes: epidemic keratoconjunctivitis (EKC) and pharyngoconjunctival fever (PCF), which are caused by different HAdV serotypes. The exact incidence of adenoviral conjunctivitis is still poorly known. However, cases are more frequent during warmer months. The virus is endemic in the general population, and frequently causes severe disease in immunocompromised patients, especially the pediatric patients. Contagion is possible through direct contact or fomites, and the virus is extremely resistant to different physical and chemical agents. The clinical signs or symptoms of conjunctival infection are similar to any other conjunctivitis, with a higher incidence of pseudomembranes. In the cornea, adenoviral infection may lead to keratitis nummularis. Diagnosis is mainly clinical, but its etiology can be confirmed using cell cultures, antigen detection, polymerase chain reaction or immunochromatography. Multiple treatments have been tried for this disease, but none of them seem to be completely effective. Prevention is the most reliable and recommended strategy to control this contagious infection.

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Section: Adenovirus: Biology Classification and Associated Diseasesmentioning

confidence: 99%

Human adenovirus: Viral pathogen with increasing importance

Ghebremedhin¹

2014

European Journal of Microbiology and Immunology

292

242

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“…Adenovirus is a human DNA virus that currently includes 51 serotypes and six species (Benko 2000; Shenk and Horwitz 2001) and has been shown to induce multiple tumors in newborn hamsters including neuroectodermal tumors and medulloblastoma (Yabe et al 1962; Hohlweg et al 2004). Kosulin et al recently screened a series of 538 solid tumors and leukemias/lymphomas for the presence of adenovirus subtypes by real-time PCR and ISH (Kosulin et al 2007).…”

Section: Detection Of Adenovirus In Primary Cns Malignanciesmentioning

confidence: 99%

Chronic Viral Infection and Primary Central Nervous System Malignancy

Saddawi‐Konefka

Crawford

2010

J Neuroimmune Pharmacol

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Primary central nervous system (CNS) tumors cause significant morbidity and mortality in both adults and children. While some of the genetic and molecular mechanisms of neuro-oncogenesis are known, much less is known about possible epigenetic contributions to disease pathophysiology. Over the last several decades, chronic viral infections have been associated with a number of human malignancies. In primary CNS malignancies, two families of viruses, namely polyomavirus and herpesvirus, have been detected with varied frequencies in a number of pediatric and adult histological tumor subtypes. However, establishing a link between chronic viral infection and primary CNS malignancy has been an area of considerable controversy, due in part to variations in detection frequencies and methodologies used among researchers. Since a latent viral neurotropism can be seen with a variety of viruses and a widespread seropositivity exists among the population, it has been difficult to establish an association between viral infection and CNS malignancy based on epidemiology alone. While direct evidence of a role of viruses in neuro-oncogenesis in humans is lacking, a more plausible hypothesis of neuro-oncomodulation has been proposed. The overall goals of this review are to summarize the many human investigations that have studied viral infection in primary CNS tumors, discuss potential neuro-oncomodulatory mechanisms of viral-associated CNS disease and propose future research directions to establish a more firm association between chronic viral infections and primary CNS malignancies.

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“…Over 100 Ad family members have been identified and characterized in a wide range of host organisms, from a variety of mammals and birds, to reptiles and amphibians (3). In the early 1960s, researchers showed that some human Ads can cause tumours in rodents (4,5), which led to a surge in studies of the molecular biology, genetics and physiology of Ads which continues to this day. Since Ads must manipulate the host cell to promote a microenvironment conducive to virus replication, studies of basic Ad biology have contributed a great deal of novel insight into all fields of cellular biology, including DNA replication, tumourigenesis and control of gene expression in the host cell.…”

Section: Introductionmentioning

confidence: 99%

Chromatin structure of adenovirus DNA throughout infection

Giberson

Davidson

Parks

2011

Nucleic Acids Research

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For more than half a century, researchers have studied the basic biology of Adenovirus (Ad), unraveling the subtle, yet profound, interactions between the virus and the host. These studies have uncovered previously unknown proteins and pathways crucial for normal cell function that the virus manipulates to achieve optimal virus replication and gene expression. In the infecting virion, the viral DNA is tightly condensed in a virally encoded protamine-like protein which must be remodeled within the first few hours of infection to allow for efficient expression of virus-encoded genes and subsequent viral DNA replication. This review discusses our current knowledge of Ad DNA–protein complex within the infected cell nucleus, the cellular proteins the virus utilizes to achieve chromatinization, and how this event contributes to efficient gene expression and progression of the virus life cycle.

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Cancer Induction in Hamsters by Human Type 12 Adenovirus. Effect of Age and of Virus Dose.

Cited by 47 publications

References 0 publications

Human adenovirus: Viral pathogen with increasing importance

Human adenovirus: Viral pathogen with increasing importance

Chronic Viral Infection and Primary Central Nervous System Malignancy

Chromatin structure of adenovirus DNA throughout infection

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