Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts

Marie-Egyptienne, Delphine T.; Chaudary, Naz; Kalliomäki, Tuula; Hedley, David W.; Hill, Richard P.

doi:10.18632/oncotarget.13625

Cited by 9 publications

(9 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CA9 was found to be overexpressed in many cancers and suggested as a common feature of cancer cells 30 , 33 - 42 . It indicated that CA9 was required for tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix

et al. 2018

View full text Add to dashboard Cite

This study aimed to explore the involvement of carbonic anhydrase 9 (CA9) single nucleotide polymorphisms (SNPs) in the development of invasive cancer of uterine cervix for Taiwanese women. Ninety-seven patients with cervical invasive squamous cell carcinoma and 88 with preinvasive squamous cell lesions as well as 324 control women were recruited. Two CA9 SNPs in exons, including rs2071676 (+201, G/A) in exon 1 and rs3829078 (+1081, A/G) in exon 7, rs1048638 (+1584, C/A) in 3′-untranslated region of exon 11, as well as an 18-base pair deletion/insertion (376deltion393) in exon 1 were selected and their genotypic distributions were determined by real-time polymerase chain reaction. Haplotype was then constructed with rs2071676, 376del393, rs3829078 and rs1048638 in order. The results revealed that Taiwanese women with genotypes CA or CA/AA in CA9 SNP rs1048638 displayed a more risk in developing cervical invasive cancer, assigning wild genotype CC as a reference. AA in SNP rs2071676 tended to increase the risk of developing cervical invasive cancer, using GG/GA as a reference. When women had the diplotypes, carrying at least one haplotype A1AA (one mutant allele A in rs2071676, no deletion in 376del393, no mutant allele A in rs3829078 and one mutant allele A in rs1048638), they were significantly susceptible to cervical invasive cancer. In conclusion, CA9 SNP rs1048638 and haplotype A1AA are associated with the susceptibility of cervical invasive squamous cell carcinoma for Taiwanese women.

show abstract

“…CA9 was found to be overexpressed in many cancers and suggested as a common feature of cancer cells 30 , 33 - 42 . It indicated that CA9 was required for tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix

et al. 2018

View full text Add to dashboard Cite

show abstract

“…On the other hand, survival of microenvironmental stresses including hypoxia and acidosis depend on the enzyme activity of the catalytic domain as described above. It is believed that metastatic lesions are generated by cancer stem cells and CA IX expression was shown to be associated with stem-like phenotype [80, 81].…”

Section: Ca IX Contributions To Key Steps Of Cancer Developmentmentioning

confidence: 99%

The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond

Pastoreková

Gillies

2019

Cancer Metastasis Rev

305

214

View full text Add to dashboard Cite

Cancer development is a complex process that follows an intricate scenario with a dynamic interplay of selective and adaptive steps and an extensive cast of molecules and signaling pathways. Solid tumor initially grows as an avascular bulk of cells carrying oncogenic mutations until diffusion distances from the nearest functional blood vessels limit delivery of nutrients and oxygen on the one hand and removal of metabolic waste on the other one. These restrictions result in regional hypoxia and acidosis that select for adaptable tumor cells able to promote aberrant angiogenesis, remodel metabolism, acquire invasiveness and metastatic propensity, and gain therapeutic resistance. Tumor cells are thereby endowed with capability to survive and proliferate in hostile microenvironment, communicate with stroma, enter circulation, colonize secondary sites, and generate metastases. While the role of oncogenic mutations initializing and driving these processes is well established, a key contribution of non-genomic, landscaping molecular players is still less appreciated despite they can equally serve as viable targets of anticancer therapies. Carbonic anhydrase IX (CA IX) is one of these players: it is induced by hypoxia, functionally linked to acidosis, implicated in invasiveness, and correlated with therapeutic resistance. Here, we summarize the available experimental evidence supported by accumulating preclinical and clinical data that CA IX can contribute virtually to each step of cancer progression path via its enzyme activity and/or non-catalytic mechanisms. We also propose that targeting tumor cells that express CA IX may provide therapeutic benefits in various settings and combinations with both conventional and newly developed treatments.

show abstract

“…It is known that CtBPs promote the formation of SCLC cells [35,40,49] and CAIX has also been clearly demonstrated to be an important marker of cells with a stem cell-like phenotype [66,78]. In this light, we investigated the role of glycolysis-CtBP-NADH axis in the formation of SCLC cells in MCF-7 breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Glycolysis, via NADH‐dependent dimerisation of CtBPs, regulates hypoxia‐induced expression of CAIX and stem‐like breast cancer cell survival

et al. 2020

View full text Add to dashboard Cite

Adaptive responses to hypoxia are mediated by the hypoxia‐inducible factor (HIF) family of transcription factors. These responses include the upregulation of glycolysis to maintain ATP production. This also generates acidic metabolites, which require HIF‐induced carbonic anhydrase IX (CAIX) for their neutralisation. C‐terminal binding proteins (CtBPs) are coregulators of gene transcription and couple glycolysis with gene transcription due to their regulation by the glycolytic coenzyme NADH. Here, we find that experimental manipulation of glycolysis and CtBP function in breast cancer cells through multiple complementary approaches supports a hypothesis whereby the expression of known HIF‐inducible genes, and CAIX in particular, adapts to available glucose in the microenvironment through a mechanism involving CtBPs. This novel pathway promotes the survival of stem cell‐like cancer (SCLC) cells in hypoxia.

show abstract

Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts

Cited by 9 publications

References 72 publications

Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix

Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix

The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond

Glycolysis, via NADH‐dependent dimerisation of CtBPs, regulates hypoxia‐induced expression of CAIX and stem‐like breast cancer cell survival

Contact Info

Product

Resources

About