2024
DOI: 10.3892/ol.2024.14559
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Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation

Ping Xu,
Zusheng Du,
Xiaohong Xie
et al.

Abstract: During the progression of renal cell carcinoma (RCC), tumor growth, metastasis and treatment response heterogeneity are regulated by both the tumor itself and the tumor microenvironment (TME). The aim of the present study was to investigate the role of the TME in RCC and construct a crosstalk network for clear cell RCC (ccRCC). An additional aim was to evaluate whether TNF receptor superfamily member 1A (TNFRSF1A) is a potential therapeutic target for ccRCC. Single-cell data analysis of RCC was performed using… Show more

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