Cancer Metastatic to the Orbit

Abstract

The most common primary cancers that metastasize to the orbit are breast, prostate gland, and lung cancer. In 19%, there is no history of cancer when the patient presents with ophthalmic symptoms and in 10% the primary site remains obscure despite systemic evaluation. The systemic prognosis is generally poor.

Metastatic prostatic adenocarcinoma to the orbit diagnosed by prostate-specific antigen staining

“…In Shields' series, the primary tumour remained obscure despite systemic evaluation in 10% of metastatic orbital tumours. 6 In the current case, immunoperoxidase stains for PSA in orbital lesions and abnormal serum PSA provide us a hint to make an effort to explore the primary prostate carcinoma by thorough evaluations and repeat biopsies. Although the survival rate for patients with metastatic prostate cancer at diagnosis is relatively poor (median survival was 2.5 years), 7 timely intervention based on early diagnosis may improve their prognosis.…”

Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

“…Complications include retinal detachment, uveitis, papilledema and secondary glaucoma. 1,2,8,29 Appropriate investigations require consideration of the patient's clinical status and goals. If the patient has a previously-confirmed cancer diagnosis, it would be reasonable to defer further workup in favour of immediate treatment.…”

“…1,5,31 Alternatively, if the tumour is accessible and wellcircumscribed, excisional biopsy could be considered. 2 …”

“…In 25% of these, it is the presenting sign of malignancy. [1][2][3][4] Frequently, this presents a diagnostic challenge and represents a poor prognosis. 5 We present an unusual case of proptosis as the index sign of malignancy and review the literature surrounding orbital and ocular metastases in prostate cancer and renal cell carcinoma (RCC).…”

Metástase orbital como primeira manifestação clínica de hepatocarcinoma

“…A ocorrência de doença metastática na órbita varia de um a treze por cento entre todos os tumores orbitários (2) . Os sítios primários mais comuns de metástases orbitais são: mama (em mulheres), pulmão e próstata (em homens) (3)(4) .…”