Cancer‐Mitochondria Dual‐Targeting Glycol/Ferrocenium‐Based Polydopamine Nanoparticles for Synergistic Photothermal and Photodynamic Therapy

Abstract

A cancer-mitochondria dual-targeting nanoparticle based on lactose and ferrocenium derivatives conjugated polydopamine (PDA@Lac/Fc/Hyp) was constructed, which exhibited cancertargeting and mitochondria-targeting ability deriving from lactose and ferrocenium derivatives due to the specific carbohydrate-protein interaction and cationic species properties, respectively. Moreover, PDA@Lac/Fc/Hyp showed great biocompatibility and phototherapeutic efficiency. This work displays a good example of constructing cancer-mitochondria dual-targeting nanoparticle for synergistic phototherapy.

Fabrication of Poly Dopamine@poly (Lactic Acid-Co-Glycolic Acid) Nanohybrids for Cancer Therapy via a Triple Collaboration Strategy

“…Unlike widely used metal-and carbon-based photothermal materials, PDA nanoparticles have excellent biocompatibility, good photothermal stability, negligible cytotoxicity, and can greatly reduce inflammatory reactions [27][28][29]. In addition, PDA nanoparticles have rich aromatic rings on their surface, which can load chemical drugs on their surface through π-π stacking and/or hydrogen bonding [30,31]. They also have chemically active catechol and quinone groups on their surfaces to facilitate further modifications for other functions, such as enhanced blood circulation or cell targeting [32].…”

A disulfide-induced supra-amphiphilic co-assembly for glycosylated pro-drug-photosensitizer nanoparticles in combination therapies

“…Herein, a hydrophilic dimer lactose molecule (Lac-SS-Lac) 22 was synthesized from the lactose and diethylene glycol extended disulfide bond. The EGFR-targeted drug gefitinib (Gef) 23 and the new generation of dual phototherapy (photodynamic therapy and photothermal therapy) photosensitizer Aza-BODIPY (BOD) 24 were selected as two drugs with different functions to synthesize a disulfide bond containing hydrophobic heterodimer prodrug molecules (pro-drug-photosensitizer, BG 25 ).…”