Cancer morbidity in alcohol abusers

Tønnesen, Hanne; Møller, Henrik; Andersen, Jens Rikardt; Jensen, Eric H.; Juel, Knud

doi:10.1038/bjc.1994.59

Cited by 90 publications

(58 citation statements)

References 62 publications

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“…In the present investigation, there was a positive, dose-responsive relationship between alcohol consumption and HSIL risk and this has been supported by other studies [44]. Smoking was also positively associated with HSIL risk and this is also consistent with previous studies [45].…”

Section: Discussionsupporting

confidence: 82%

Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B₁₂

Hernandez

McDuffie

Wilkens

et al. 2003

Cancer Causes Control

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Objective: A case-control study was conducted among a population of multiethnic women identified from clinics on Oahu, Hawaii between 1992 and 1996 to explore the relationship between diet and cervical dysplasia. Methods: Two-hundred and fourteen women with biopsy-confirmed high and low grade squamous intraepithelial lesions of the cervix (SIL) and 271 controls were identified. Exfoliated cervical cells were collected for HPV DNA testing. Surveys were administered to assess non-dietary risk factors and intake of nutrients from over 250 specific food items as well as nutritional supplements. Results: Riboflavin and thiamin from food sources, vitamin B 12 supplements, and total (food and supplements) folate displayed inverse, dose-responsive associations with high-grade SIL (HSIL). Riboflavin from food sources and total folate also demonstrated inverse, dose-responsive associations with low-grade SIL (LSIL). The odds ratios for LSIL and HSIL were reduced by 50-90% for the highest compared to the lowest levels of intake of these nutrients. A number of major food sources of these vitamins, including all types of breads, bran cereal, and fruit juice, also demonstrated inverse associations with HSIL. There was some evidence that the increased risk of HSIL associated with low nutrient intake was most pronounced among drinkers and smokers. Conclusions: This investigation provides evidence that thiamin, riboflavin, folate, and vitamin B 12 may play a protective role in cervical carcinogenesis.

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Section: Discussionsupporting

confidence: 82%

Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B₁₂

Hernandez

McDuffie

Wilkens

et al. 2003

Cancer Causes Control

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“…A cohort study of more than 3,000 Danish women in treatment for alcohol abuse followed for a mean of 9.4 years found no increased risk of endometrial or ovarian cancer, compared with the entire female Danish population. 221 A similar Swedish study also found no association. 222 In addition, a populationbased cohort study 223 and a number of case-control studies [224][225][226][227][228] have found no significant adverse association between relatively low-level alcohol consumption and endometrial cancer 224,[226][227][228] or ovarian cancer.…”

Section: Alcohol-related Consequences Unique To Womenmentioning

confidence: 64%

“…The Danish cohort study mentioned above observed an increased risk of cervical cancer in women treated for alcohol-related problems (RR 2.0; 95% CI 1.2, 3.0) compared with the general Danish population. 221 A similar Swedish retrospective cohort study also found an association between cervical, vaginal, and vulvar cancers in women registered with temperance boards. 222 However, both these studies, and another smaller one reporting a similar association, 232 were unable to control for known risk factors for cervical cancer or rates of Pap screening.…”

Section: Alcohol-related Consequences Unique To Womenmentioning

confidence: 86%

Medical risks for women who drink alcohol

et al. 1998

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OBJECTIVE:To summarize for clinicians recent epidemiologic evidence regarding medical risks of alcohol use for women.METHODS: MEDLINE and PsychINFO, 1990 through 1996, were searched using key words "women" or "woman," and "alcohol." MEDLINE was also searched for other specific topics and authors from 1980 through 1996. Data were extracted and reviewed regarding levels of alcohol consumption associated with mortality, cardiovascular disease, alcoholrelated liver disease, injury, osteoporosis, neurologic symptoms, psychiatric comorbidity, fetal alcohol syndrome, spontaneous abortion, infertility, menstrual symptoms, breast cancer, and gynecologic malignancies. Gender-specific data from cohort studies of general population or large clinical samples are primarily reviewed. MAIN RESULTS:Women develop many alcohol-related medical problems at lower levels of consumption than men, probably reflecting women's lower total body water, gender differences in alcohol metabolism, and effects of alcohol on postmenopausal estrogen levels. Mortality and breast cancer are increased in women who report drinking more than two drinks daily. Higher levels of alcohol consumption by women are associated with increased menstrual symptoms, hypertension, and stroke. Women who drink heavily also appear to have increased infertility and spontaneous abortion. Adverse fetal effects occur after variable amounts of alcohol consumption, making any alcohol use during pregnancy potentially harmful. CONCLUSIONS:In general, advising nonpregnant women who drink alcohol to have fewer than two drinks daily is strongly supported by the epidemiologic literature, although specific recommendations for a particular woman should depend on her medical history and risk factors. L ess than three quarters of women in the UnitedStates drink alcohol, and those who do drink consume fewer drinks and less absolute alcohol than men. 1 However, at similar levels of self-reported alcohol consumption, the risk of psychosocial problems or dependence is greater for women than men (for definitions, see Appendix A). [2][3][4][5][6] Women also appear to develop alcohol abuse and dependence after fewer years of drinking than men. 7 Although only 4% to 5% of women in the U.S. general population meet criteria for past-year alcohol abuse or dependence, 8,9 9% of female primary care patients in some studies have reported recent heavy drinking or alcohol-related problems. 10,11 Many heavy drinkers decrease consumption following brief interventions that include explicit advice about safe drinking limits. [12][13][14] In addition, offering feedback about specific risks or consequences of their drinking to patients who drink heavily can help motivate them to decrease alcohol consumption or seek treatment. 15,16 Physicians report they would be more likely to advise patients about safe drinking practices if they were more confident of their knowledge about safe levels of alcohol consumption. 17 Women who drink more than two drinks daily on average, or who frequently drink five or more d...

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“…However, owing to small case numbers, previous prospective studies have typically collapsed cancers of the head and neck and the aesophagus into a single broad category of upper-gastrointestinal tract sites (Gronbaek et al, 1998;Kjaerheim et al, 1998;Boeing, 2002). Few prospective studies have examined the association between alcohol and individual head and neck cancer sub-sites, such as the larynx, oral cavity, or pharynx (Schottenfeld et al, 1974;Boffetta and Garfinkel, 1990;Adami et al, 1992;Tonnesen et al, 1994;Sigvardsson et al, 1996;Boffetta et al, 2001). Most of these studies have not adjusted for tobacco use, an important potential confounder of the relation between alcohol and head and neck cancer (Boffetta and Garfinkel, 1990).…”

mentioning

confidence: 99%

Alcohol and head and neck cancer risk in a prospective study

et al. 2007

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We investigated the relation between head and neck cancer risk and alcohol consumption in the NIH-AARP Diet and Health Study. During 2 203 500 person-years of follow-up, 611 men and 183 women developed head and neck cancer. With moderate drinking (up to one alcoholic drink per day) as the referent group, non-drinkers showed an increased risk of head and neck cancer (men: hazard ratio (HR) 1.68, 95% confidence interval (95% CI) 1.37 -2.06; women: 1.46, 1.02 -2.08). Among male and female alcohol drinkers, we observed a significant dose -response relationship between alcohol consumption and risk. The HR for consuming 43 drinks per day was significantly higher in women (2.52, 1.46 -4.35) than in men (1.48, 1.15 -1.90; P for interaction ¼ 0.0036). The incidence rates per 100 000 person-years for those who consumed 43 drinks per day were similar in men (77.6) and women (75.3). The higher HRs observed in women resulted from lower incidence rates in the referent group: women (14.7), men (34.4). In summary, drinking 43 alcoholic beverages per day was associated with increased risk in men and women, but consumption of up to one drink per day may be associated with reduced risk relative to non-drinking. British Journal of Cancer (2007) Each year, more than 600 000 individuals are diagnosed with squamous cancers of the head and neck worldwide (Parkin et al, 2005). Head and neck cancer has multiple anatomic sub-sites, including the oral cavity, pharynx, and larynx, which may have distinct aetiologies.Alcohol use has consistently been indicated as a risk factor for head and neck cancer (Sturgis et al, 2004). However, owing to small case numbers, previous prospective studies have typically collapsed cancers of the head and neck and the aesophagus into a single broad category of upper-gastrointestinal tract sites (Gronbaek et al, 1998;Kjaerheim et al, 1998;Boeing, 2002). Few prospective studies have examined the association between alcohol and individual head and neck cancer sub-sites, such as the larynx, oral cavity, or pharynx (Schottenfeld et al, 1974;Boffetta and Garfinkel, 1990;Adami et al, 1992;Tonnesen et al, 1994;Sigvardsson et al, 1996;Boffetta et al, 2001). Most of these studies have not adjusted for tobacco use, an important potential confounder of the relation between alcohol and head and neck cancer (Boffetta and Garfinkel, 1990). Also, few studies (Franceschi et al, 1994;Gronbaek et al, 1998;Hayes et al, 1999;Castellsague et al, 2004;Polesel et al, 2005) have examined non-drinkers and those that drink less than two drinks per day separately, an important comparison as consumption of less than two drinks per day may reduce cardiovascular disease risk (Maclure, 1993).Although men are 2 -7 times more likely to develop these cancers than women (depending on sub-site) (Parkin et al, 2005), few epidemiological studies have compared the association of alcohol and head and neck cancer in men to that in women (Blot et al, 1988;Franceschi et al, 1994;Hayes et al, 1999;Boffetta et al, 2001). These studies generally indicate...

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Cancer morbidity in alcohol abusers

Cited by 90 publications

References 62 publications

Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B₁₂

Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B₁₂

Medical risks for women who drink alcohol

Alcohol and head and neck cancer risk in a prospective study

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Cancer morbidity in alcohol abusers

Cited by 90 publications

References 62 publications

Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12

Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12

Medical risks for women who drink alcohol

Alcohol and head and neck cancer risk in a prospective study

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Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B₁₂

Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B₁₂