Cancer nanotheranostics in the second near‐infrared window

Jiang, Shanshan; Huang, Kai; Qu, Junle; Lin, Jing; Huang, Peng

doi:10.1002/viw.20200075

Cited by 35 publications

(23 citation statements)

References 75 publications

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“…First, biocompatibility is critical for clinical approval, thus the stability and metabolic property should be considered when designing the probes 150 . Especially, for the nanostructures, controlling the hydrodynamic sizes below 5.5 nm can drive them excreted via the urinary system to decrease cumulative toxicity and benefit their potential clinical applications 151 - 153 .…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Activatable NIR-II organic fluorescent probes for bioimaging

Zhang¹,

Li²,

Ma³

et al. 2022

Theranostics

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NIR-II imaging is developed rapidly for noninvasive deep tissue inspection with high spatio-temporal resolution, taking advantage of diminished autofluorescence and light attenuation. Activatable NIR‐II fluorescence probes are widely developed to report pathological changes with accurate targeting, among which organic fluorescent probes achieve significant progress. Furthermore, the activatable NIR‐II fluorescent probes exhibited appealing characteristics like tunable physicochemical and optical properties, easy processability, and excellent biocompatibility. In the present review, we highlight the advances of activatable NIR-II fluorescence probes in design, synthesis and applications for imaging pathological changes like reactive oxygen species (ROS), reactive nitrogen species (RNS), reactive sulfur species (RSS), pH, hypoxia, viscosity as well as abnormally expressed enzymes. This non-invasive optical imaging modality shows a promising prospect in targeting the pathological site and is envisioned for potential clinical translation.

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Section: Conclusion and Perspectivementioning

confidence: 99%

Activatable NIR-II organic fluorescent probes for bioimaging

Zhang¹,

Li²,

Ma³

et al. 2022

Theranostics

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“…In particular, NIR‐II activatable NPSs would not only resolve an issue of low penetration depth but also reduce the overall complexity and cost of the system. [ 132 ] Recently, Huang et al demonstrated an innovative strategy to modulate the plasmonic peak of gold‐based theranostic systems in NIR‐II region to achieve deep‐seated tumor theranostics. [ 133 ] Meanwhile, biocompatible and biodegradable NPSs (e.g., black phosphorus NSs, hybrid‐based NPSs) capable of reducing side toxicity in vivo are greatly needed.…”

Section: Current Challenges and Future Prospectsmentioning

confidence: 99%

Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy

Younis

et al. 2021

Advanced Science

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Inorganic nanomaterials with intrinsic singlet oxygen (1O2) generation capacity, are emerged yet dynamically developing materials as nano‐photosensitizers (NPSs) for photodynamic therapy (PDT). Compared to previously reported nanomaterials that have been used as either carriers to load organic PSs or energy donors to excite the attached organic PSs through a Foster resonance energy transfer process, these NPSs possess intrinsic 1O2 generation capacity with extremely high 1O2 quantum yield (e.g., 1.56, 1.3, 1.26, and 1.09) than any classical organic PS reported to date, and thus are facilitating to make a revolution in PDT. In this review, the recent advances in the development of various inorganic nanomaterials as NPSs, including metal‐based (gold, silver, and tungsten), metal oxide‐based (titanium dioxide, tungsten oxide, and bismuth oxyhalide), metal sulfide‐based (copper and molybdenum sulfide), carbon‐based (graphene, fullerene, and graphitic carbon nitride), phosphorus‐based, and others (hybrids and MXenes‐based NPSs) are summarized, with an emphasis on the design principle and 1O2 generation mechanism, and the photodynamic therapeutic performance against different types of cancers. Finally, the current challenges and an outlook of future research are also discussed. This review may provide a comprehensive account capable of explaining recent progress as well as future research of this emerging paradigm.

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“…To date, although several review articles [ 7,54–57 ] have been published in the area of NIR‐II fluorophores, herein we aim to provide a comprehensive review which highlight the current advances of AIE nanomaterials in molecular design and biomedical applications. AIE nanoprobes either emit NIR‐II light or excited (via multiphoton excitation) by NIR‐II light are included.…”

Section: Introductionmentioning

confidence: 99%

Aggregation‐Induced Emission Nanoprobes Working in the NIR‐II Region: From Material Design to Fluorescence Imaging and Phototherapy

Jiang

Fan

et al. 2021

Advanced Optical Materials

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In recent years, with increasing demands for in vivo fluorescence imaging and photodynamic therapy, light in the second near‐infrared window (NIR‐II; 1000–1700 nm) has attracted tremendous interest because it offers numerous merits, including deep penetration, minimal phototoxicity, diminished tissue autofluorescence, and reduced tissue absorption and scattering. Among the diverse types of nanoparticles, organic nanoprobes with aggregation‐induced emission (AIE) characteristics have emerged as a better option owing to their ultra‐brightness, excellent photostability, low cytotoxicity, and tailorable optical properties. Recent efforts in the AIE realm have revealed advancements in molecular design for long wavelength absorption and multiphoton excitation, which efficiently modulate the working optical region to the NIR‐II region. In this review, the current status of AIE nanoprobes in the NIR‐II window is summarized. Starting with molecular design strategies, recent efforts in fluorescence imaging and photodynamic therapy are then discussed. Finally, perspectives and challenges in this newly emerging field are given. This review hopes to encourage more innovative ideas in material design and biomedical applications for promoting AIE nanoprobes for future clinical translation.

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Cancer nanotheranostics in the second near‐infrared window

Cited by 35 publications

References 75 publications

Activatable NIR-II organic fluorescent probes for bioimaging

Activatable NIR-II organic fluorescent probes for bioimaging

Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy

Aggregation‐Induced Emission Nanoprobes Working in the NIR‐II Region: From Material Design to Fluorescence Imaging and Phototherapy

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