Cancer of appendix as a presenting feature of Crohn's disease

Sonwalkar, Sunil; Denyer, Mark; Verbeke, Caroline; Guillou, Pierre J.

doi:10.1097/00042737-200209000-00017

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…Involvement of the appendix in CD is not uncommon, 27, 28 however, few appendiceal adenocarcinoma in CD have been previously described. 29, 30 While this finding is undoubtedly important, it is unclear whether the colonic dysplasia was at all related to the appendiceal cancer or whether this was a coincidence. However, given this patient’s history of pancolitis involving the cecum, it is reasonable to believe that the adenocarcinoma was preceded by long standing CD involving the appendix.…”

Section: Discussionmentioning

confidence: 94%

Surveillance of IBD Using High Definition Colonoscopes Does Not Miss Adenocarcinoma in Patients with Low-grade Dysplasia

Cleveland

Colman

Rodriquez

et al. 2016

Inflammatory Bowel Diseases

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Background Historically, limits to the ability to detect dysplasia in chronic inflammatory bowel disease (IBD)-associated colitis resulted in the recommendation that neoplasia of any grade be treated by proctocolectomy. We hypothesized that with improved optical technologies, most neoplasia in colitis is now detectable and reassessed the prevalence of colitis-associated neoplasia. Methods We retrospectively reviewed all our patients with IBD who had pathologist-confirmed neoplasia on surveillance colonoscopy and underwent a subsequent colectomy. We included patients whose index lesions were found between 2005 and 2014 (the dates of our high definition equipment) and recorded the location and grade of these lesions. These findings were compared to the surgical specimens, and in patients with partial colectomies, included follow-up. Results Thirty-six patients with IBD (19 [53%] ulcerative colitis, 17 [47%] Crohn’s disease) were found to have neoplastic lesions on surveillance colonoscopy and underwent a subsequent partial colectomy or total proctocolectomy. Fourty-four index lesions were identified by colonoscopy (29 white light and 7 methylene blue chromoscopy): 30 low-grade dysplasia, 6 high-grade dysplasia, and 8 adenocarcinoma. None of the low-grade dysplasia or adenocarcinoma index lesions were associated with synchronous carcinoma at colectomy. One of the patients with high-grade dysplasia had adenocarcinoma of the appendix. Conclusions In this experience with high definition colonoscopes in chronic colitis, no synchronous adenocarcinomas were found when colectomy was performed for low grade dysplasia and only 1 adenocarcinoma in the appendix was found in the setting of high-grade dysplasia. These findings suggest that active surveillance or subtotal colectomy, may be safe options for patients with IBD and some grades of neoplasia.

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Section: Discussionmentioning

confidence: 94%

Surveillance of IBD Using High Definition Colonoscopes Does Not Miss Adenocarcinoma in Patients with Low-grade Dysplasia

Cleveland

Colman

Rodriquez

et al. 2016

Inflammatory Bowel Diseases

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“…AMNs remain a rare clinical entity in IBD patients: to this date, current evidence relies on 22 [ 18 , 19 , 21 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ] case reports and only 1 retrospective case–control study [ 14 ]. To our knowledge, this is the very first review of cases of AMN in IBD patients.…”

Section: Discussionmentioning

confidence: 99%

Appendiceal Mucinous Neoplasms and Inflammatory Bowel Disease: Systematic Review of the Literature

Bonomi,

Ferrario,

Frontali

et al. 2023

JCM

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There is no clear evidence on the prevalence and clinical presentation of appendiceal mucinous neoplasm (AMN) among patients with inflammatory bowel disease (IBD), so a systematic review was performed to investigate the diagnosis, management and treatment of AMN in these patients. PubMed, Medline, Scopus and the Cochrane Library were searched for articles published up to September 2023. Twenty-three studies reporting data about 34 AMN patients were included. UC patients had a median age of 52 years and a median length of disease of 10 years; CD patients had a median age of 40.5 years and a median length of disease of 5 years. A pre-operative diagnosis was achieved in 44% of patients. Most patients were symptomatic (82.6%) and showed moderate–severe disease activity (61%). Surgical procedures were performed: laparoscopic appendectomy, ileocecal resection, right hemicolectomy and colectomy/proctocolectomy. Of the patients, 73.5% were diagnosed with low-grade mucinous neoplasm (LAMN) and nine with adenocarcinoma. Synchronous colorectal dysplasia/carcinoma was present in 23.5% of patients. IBD patients with long-standing disease should be routinely screened, not only for colorectal cancer but also for AMN, during gastro-enterologic follow-up. Laparoscopic appendectomy of unruptured LAMN as well as right hemicolectomy of non-metastatic adenocarcinoma are safe procedures in IBD patients.

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Appendiceal Mucinous Cystadenoma is a Neoplastic Complication Of IBD: Case-Control Study of Primary Appendiceal Neoplasms

Orta

Trindade

Luo

et al. 2009

Inflammatory Bowel Diseases

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Cancer of appendix as a presenting feature of Crohn's disease

Cited by 5 publications

References 16 publications

Surveillance of IBD Using High Definition Colonoscopes Does Not Miss Adenocarcinoma in Patients with Low-grade Dysplasia

Surveillance of IBD Using High Definition Colonoscopes Does Not Miss Adenocarcinoma in Patients with Low-grade Dysplasia

Appendiceal Mucinous Neoplasms and Inflammatory Bowel Disease: Systematic Review of the Literature

Appendiceal Mucinous Cystadenoma is a Neoplastic Complication Of IBD: Case-Control Study of Primary Appendiceal Neoplasms

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