Cancer of Other Origin

Davidson, Ben; Michael, Claire; Firat, Pınar

doi:10.1007/978-3-319-76478-8_7

Cited by 5 publications

(8 citation statements)

References 137 publications

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“…They might also take the shape of signet ring cells, a characteristic of breast lobular carcinoma and gastric adenocarcinoma, or form papillae, which are common in lung, breast, and thyroid cancers. When it comes to metastatic adenocarcinoma, the predominant origins are the lungs, followed by the digestive system, the pancreatic and biliary regions, and finally, the genitourinary system [6,7]. In males, the primary locations where malignant pleural effusions frequently occur include the lungs, lymphatic system, digestive organs, and pancreas [6,7].…”

Section: Discussionmentioning

confidence: 99%

Cytopathological Features of Extensive Bilateral Pleural Effusions in Metastatic Prostate Cancer: Report of a Rare Case

Huang,

Yap

2024

Cureus

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Section: Discussionmentioning

confidence: 99%

Cytopathological Features of Extensive Bilateral Pleural Effusions in Metastatic Prostate Cancer: Report of a Rare Case

Huang,

Yap

2024

Cureus

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“…Given the fact that LGSC is often diagnosed in young women, considerable efforts have been made in recent years to identify molecular targets amenable to therapy, with the hope of extending survival and improving outcomes (reviewed in [3][4][5]). Cancer cells in serous effusions are molecularly different from their counterparts in solid lesions, 22 and there is, therefore, an obvious need to characterise the genomic profile of LGSC at this anatomical site. A small series of surgical specimens was additionally studied, with an emphasis on metastatic lesions.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Dissemination of tubo-ovarian carcinoma within the peritoneal cavity, and less frequently the pleural cavity, in the form of malignant effusion commonly occurs, particularly with advanced-stage serous carcinoma. 22 Thus, despite the fact that LGSC is an uncommon tumour, its relative incidence in serous effusions is somewhat higher.…”

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confidence: 99%

Molecular characteristics of low‐grade serous carcinoma in effusions

et al. 2023

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Objective The molecular characteristics of low‐grade serous carcinoma (LGSC) in serous effusions have not been studied previously. The present study analysed the molecular profile of LGSC at this anatomical site. Methods Specimens consisted of a series of 17 serous effusions (15 peritoneal, 2 pleural) from 16 patients, of which 15 were LGSC and 2 serous borderline tumour (SBT) who later progressed to LGSC. For comparative purposes, 9 surgical specimens from 6 patients with LGSC were analysed. Fresh‐frozen cell pellets and surgical specimens underwent targeted next‐generation sequencing covering 50 unique genes. Results Mutations were found in tumours from 14 of the 22 patients, of whom 4 had 2 different mutations and 10 had a single mutation. Overall, the most common mutations were in KRAS (n = 3) and BRAF (n = 3), followed by NRAS (n = 2), CDK2NA (n = 2), TP53 (n = 2), ATM (n = 2). Mutations in MET, STK11, ERBB2 and FLT3 were found in one case each. Patient‐matched specimens had the same molecular profile. Both effusions with TP53 mutation had concomitant ATM mutation, and both stained immunohistochemically with a wild‐type pattern. The absence of mutations was associated with a trend for shorter overall survival in univariate analysis (p = 0.072). Conclusions The molecular alterations in LGSCs in serous effusions are consistent with those found in solid tumours, with frequent alterations in the mitogen‐activated protein kinase pathway. Mutations in LGSC may be a marker of better outcomes.

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“…Cell blocks from effusion pellets were prepared using the thrombin clot protocol. Effusions were diagnosed based on smear and cell block morphology and immunohistochemistry (IHC) by an experienced cytopathologist (BD) applying established guidelines [5]. Surgical specimens were similarly diagnosed based on morphology and IHC by an experienced gynecologic pathologist (BD) based on established guidelines [2].…”

Section: Patients and Specimensmentioning

confidence: 99%

Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance

dos Santos,

Holth,

Bischof

et al. 2023

Clin Exp Metastasis

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The objective of this study was to analyze the expression and prognostic role of the tight junction protein occludin in high-grade serous carcinoma (HGSC). Occludin protein expression by immunohistochemistry was analyzed in 602 HGSC (417 effusions, 185 surgical specimens). Expression in mesothelioma (n = 87; 45 effusions, 42 surgical specimens) was studied for comparative purposes. Occludin protein expression was found in 587/602 (98%) HGSC vs. 40/87 (46%) mesotheliomas and was predominantly limited to < 5% of cells in the latter (p < 0.001). Occludin was additionally overexpressed in HGSC effusions compared to surgical specimens (p < 0.001) and was overexpressed in post-chemotherapy effusions compared to chemo-naive effusions tapped at diagnosis (p = 0.015). Occludin expression in HGSC surgical specimens was associated with poor chemoresponse (p < 0.001) and primary resistance (p = 0.001). Expression in effusions and surgical specimens was unrelated to survival (p > 0.05). In conclusion, occludin expression is higher in HGSC compared to mesothelioma, and this protein is overexpressed in HGSC effusions, possibly reflecting changes in adhesion related to anchorage-independent growth in this microenvironment. Overexpression in post-chemotherapy compared to chemo-naïve effusions suggest a role in disease progression. Occludin expression in surgical specimens may be related to chemoresistance.

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Cancer of Other Origin

Cited by 5 publications

References 137 publications

Cytopathological Features of Extensive Bilateral Pleural Effusions in Metastatic Prostate Cancer: Report of a Rare Case

Cytopathological Features of Extensive Bilateral Pleural Effusions in Metastatic Prostate Cancer: Report of a Rare Case

Molecular characteristics of low‐grade serous carcinoma in effusions

Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance

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