Cancer of the buccal mucosa: a tale of two continents

Pathak, Kumar Alok; Nason, Richard W.; Talole, Sanjay; Abdoh, Ahmed A.; Pai, Prathamesh; Deshpande, Mandar; Chaturvedi, Pankaj; Chaukar, Devendra A; D’Cruz, Anil; Bhalavat, R.

doi:10.1016/j.ijom.2008.07.009

Cited by 15 publications

(14 citation statements)

References 22 publications

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“…This is concordant with the median age reported from the Asian countries [5,6] but a decade less than that reported in the United States of America and Europe. [7] In recent years, increasing number of patients throughout the world are being diagnosed with oral cavity squamous carcinoma at a young age (less than 40 years).…”

Section: Patient Demographicssupporting

confidence: 90%

Analysis of prognostic factors in 1180 patients with oral cavity primary cancer treated with definitive or adjuvant radiotherapy

et al. 2010

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Section: Patient Demographicssupporting

confidence: 90%

Analysis of prognostic factors in 1180 patients with oral cavity primary cancer treated with definitive or adjuvant radiotherapy

et al. 2010

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“…Men and women are also almost equally affected in high prevalence regions such as South East Asia [21] [22]. Reversals in the male to female ratios have been reported such as documented by Pathak et al (2009) in Canada where a male to female ratio of 0.9:1 was noted [22]. This study focused on buccal OSCC at a Canadian Cancer centre where the high incidence of the buccal mucosa OSCC among women has been attributed to their use of snuff more than men.…”

Section: Discussionmentioning

confidence: 97%

“…The male to female pattern of affliction has, however, been shown to vary depending on geographical location and anatomical site [20]. Men and women are also almost equally affected in high prevalence regions such as South East Asia [21] [22]. Reversals in the male to female ratios have been reported such as documented by Pathak et al (2009) in Canada where a male to female ratio of 0.9:1 was noted [22].…”

Section: Discussionmentioning

confidence: 99%

Oral Squamous Cell Carcinoma: A 6-Month Clinico-Histopathologic Audit in a Kenyan Population

Muange¹,

Chindia²,

Njiru³

et al. 2014

OJST

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Objective: To determine the clinico-histopathologic variations and etiological factors associated with oral squamous cell carcinoma (OSCC). Methods: A descriptive cross-sectional hospital based study was conducted at the University of Nairobi Dental Hospital (UNDH) and Kenyatta National Hospital (KNH) between September 2008 and February 2009. Eighty-two (82) patients presenting with lesions confirmed as OSCC were evaluated for habits identified as risk factors such as tobacco use, alcohol use and betel quid chewing. Demographic features including age and gender as well as clinical parameters such as site of the primary lesion, tumour size and nodal involvement were documented. Incisional biopsies were performed for all patients to confirm the diagnosis and histopathological features noted. Results: The mean age of the patients was 58.49 (range = 14 to 90 years), with a male to female ratio of 1.6:1. Remarkably, 13.4% of the patients were aged 40 years and below. The peak incidence was found to have been in the 6 th-7 th decades. Tobacco use was the main associated etiological factor (73.2%) followed by alcohol use (57.3%). Notably, 25.6% of the cases had no identifiable risk factor. The tongue was the most common site (35%) followed by the palate (22%) (p = 0.03). The least commonly affected site was the floor of the mouth (10%). The most common stage at presentation was stage IV (52.4%) and; the poorly differentiated OSCC was the most common histopathologic variant (48.8%) followed by the well differentiated (30.5%) and moderately differentiated OSCC (20.7%). Conclusion: In the present investigation it is evident that OSCC has a male predilection with a peak incidence in the 6 th-7 th decades and most commonly manifests in the tongue at stage IV with the poorly differentiated subtype being the most common. Of the cases diagnosed 13.4% were aged 40 years and below.

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“…After adjusting for age, there was no difference in overall survival (Hazard Ratio = 0.84; 95% CI = 0.51-1.40; P = 0.509). 29,30 OSMF is a unique potentially malignant disorder limited to the Indian subcontinent. Murti et al found a malignant transformation rate of 4.5% over 15 years of observation period (median 8 years).…”

Section: Ethnic Differences In Head Neck Cancersmentioning

confidence: 99%

“…The study found both groups of patients to have similar cause specific survival (76.4% vs. 74.2%, P = 0.69). After adjusting for age, there was no difference in overall survival (Hazard Ratio = 0.84; 95% CI = 0.51‐1.40; P = 0.509) …”

Section: Introductionmentioning

confidence: 96%

Head and neck cancers in India

Dandekar¹,

Tuljapurkar

Dhar

et al. 2017

Journal of Surgical Oncology

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Head and neck cancers constitute a third of the cancer burden in India. These cancers have unique patient characteristics, presentation, and etiological differences from those in the West. Socioeconomic constraints, large patient population, scarcity of trained health workers, and inadequate infrastructure are major challenges faced in the management of these cancers. Despite these constraints, patients are treated with evidence based guidelines that are tailored to the local scenario.

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Cancer of the buccal mucosa: a tale of two continents

Cited by 15 publications

References 22 publications

Analysis of prognostic factors in 1180 patients with oral cavity primary cancer treated with definitive or adjuvant radiotherapy

Analysis of prognostic factors in 1180 patients with oral cavity primary cancer treated with definitive or adjuvant radiotherapy

Oral Squamous Cell Carcinoma: A 6-Month Clinico-Histopathologic Audit in a Kenyan Population

Head and neck cancers in India

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