Cancer of the gallbladder—Chilean statistics

Olivares, Luis Villanueva

doi:10.3332/ecancer.2016.704

Cited by 16 publications

(7 citation statements)

References 14 publications

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“…The highest recorded incidence rates are in Chile with 9.7 new cases for every 100,000 persons each year and in the regions of Los Lagos and Los Ríos, rates as high as 28.5 per 100,000 women. 17 The results of this study show variations in pattern and trend of GBC in different populations within Saudi Arabia. So, they highlight that GBC should not be ignored because of the overall low incidence-mortality rate (age-standardised).…”

Section: Discussionmentioning

confidence: 65%

<p>Epidemiology of Gallbladder Cancer in Saudi Arabia</p>

Alqahtani

Alghamdi

2020

CMAR

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Background: Gallbladder cancer is generally rare but can be more common in some populations. The aim of this study was to present an analysis of gallbladder cancer epidemiology in Saudi Arabia. Materials and Methods: A retrospective study of gallbladder cancer cases in Saudi Arabia from 2004 to 2015 was conducted. The gallbladder cancer data were accessed through the Saudi Cancer Registry (SCR) reports for 13 administrative regions. The number of gallbladder cancer cases with percentage, the crude incidence rate (CIR) and the agestandardised incidence rate (ASIR), stratified by regions, gender, and the years of diagnoses were analysed. Results: A total of 1678 gallbladder cancer cases, 702 in males and 976 in females, were registered between 2004 and 2015. Saudi women and men in the 75 and above age-group were found to have the highest diagnosis rate of gallbladder cancer. In males, the overall ASIR among Saudi males was 1.1 per 100,000 (95% CI, 0.9 to 1.2). The Eastern region had the highest overall ASIR at 1.5 per 100,000 males, followed by Tabuk and Riyadh at 1.4 and 1.3 higher than other regions (F(12,143)=1.930, P<0.001). The overall ASIR among Saudi females was 1.6 per 100,000 (95% CI, 1.4 to 1.7). Riyadh had the highest overall ASIR at 2.4 per 100,000 females, followed by the Eastern region, and Qassim at 1.9 and 1.5, respectively, all higher than other provinces of the country (F(12,143)=2.496, P<0.005). The ASIR and CIR were lower among males than females (ratio 0.7). Conclusion: Gallbladder cancer incidence is relatively low in Saudi Arabia. The rates were higher in females than males. ASIR showed variations between different provinces of Saudi Arabia. In females, the highest ASIR was in Riyadh. In males, ASIR was highest in the Eastern region of Saudi Arabia.

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Section: Discussionmentioning

confidence: 65%

<p>Epidemiology of Gallbladder Cancer in Saudi Arabia</p>

Alqahtani

Alghamdi

2020

CMAR

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“…As the present study showed different associations with bile sCD14 for GBC cases compared to gallstone controls, similar to the previous results for plasma sCD14 14 , it supports the potential value of circulating sCD14 in identifying risk of GBC among those with gallstones, similar to HCC risk among those with cirrhosis. Early detection is particularly important in high-risk regions, such as Chile, which has the highest GBC incidence rate and mortality rate 51 . Because bile sCD14 was shown to be associated with stage I/II cancers, it offers potential for identifying GBC early, when it is more readily treatable.…”

Section: Discussionmentioning

confidence: 99%

Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China

Brun

Corbel

Hsing

et al. 2021

Sci Rep

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Elevated systemic levels of soluble cluster of differentiation 14 (sCD14) have been associated with gallbladder cancer (GBC), but the association with sCD14 levels within the gallbladder has not been investigated. Here, we evaluated sCD14 in the bile of 41 GBC cases and 117 gallstone controls with data on 65 bile inflammation markers. We examined the relationship between bile sCD14 levels and GBC using logistic regression and stratified the analysis by stage. We included GBC-associated inflammatory biomarkers in the model to evaluate the influence of local inflammation. Bile sCD14 levels (third versus first tertile) were associated with GBC (adjusted odds ratio [OR]: 3.0, 95% confidence interval [CI]: 1.2–8.0). The association was equally strong for stage I/II (OR: 3.3, 95% CI: 0.9–15.6) and stage III/IV (OR: 3.2, 95% CI: 1.0–12.4) cancers. Including the GBC-associated inflammatory markers in the model removed the association between bile sCD14 and GBC (OR: 1.0, 95% CI: 0.3–3.5). The findings suggest that immune activation within the gallbladder may be related to GBC development, and the effect of sCD14 is influenced by inflammation. Similar associations across tumor stages suggest that elevated bile sCD14 levels may reflect changes early in GBC pathogenesis. Associations between GBC and sCD14 levels in both bile and plasma suggest sCD14 could be a potential biomarker for GBC.

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“…Similarly, some cancer types are more prevalent in certain subpopulations. For example, gallbladder cancer is disproportionally more common in Southern Chile, particularly in individuals of Mapuche ancestry, which is also associated with increased gallbladder cancer mortality ( Andia et al, 2008 ; Lorenzo Bermejo et al, 2017 ; Olivares, 2016 ). There is also evidence to suggest that increasing the genetic ancestry diversity of reference panels can directly translate into better patient stratification.…”

Section: Differences In Cancer Incidence and Biomarkers Across Popula...mentioning

confidence: 99%

Tackling the lack of diversity in cancer research

Molina-Aguilar,

Robles-Espinoza

2023

Disease Models &Amp; Mechanisms

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Despite the clear benefit of studying biological samples from diverse genetic backgrounds and geographical locations, our current knowledge of disease is mostly derived from the study of European-descent individuals. In the cancer field, this is reflected in the poor representation of African and Amerindian/Latino samples in most large public data repositories. This lack of diversity is due to several reasons, but here we focus on (1) the lack of support for studies on non-European populations that are performed in low- and middle-income countries (LMICs), and (2) unequal partnerships between scientists in LMICs and those in high-income countries. We argue that expanding access to research funding, increasing the participation of underrepresented scientists in editorial boards and international conferences, facilitating the publication of studies conducted in these countries, and properly acknowledging LMIC researchers' contributions in publications and grant applications will promote equity for scientists working in LMICs. We envisage that this will translate to more impactful research in these countries, which will include more samples from diverse populations. For the cancer field, this will broaden our understanding of pathomechanisms and may help to improve the treatment of patients from all backgrounds.

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Cancer of the gallbladder—Chilean statistics

Cited by 16 publications

References 14 publications

<p>Epidemiology of Gallbladder Cancer in Saudi Arabia</p>

<p>Epidemiology of Gallbladder Cancer in Saudi Arabia</p>

Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China

Tackling the lack of diversity in cancer research

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