Cancer of the nasopharynx. Its clinical and radiotherapeutic considerations

Wang, C. C.; Little, John B.; Schulz, Milford D.

doi:10.1002/1097-0142(196209/10)15:5<921::aid-cncr2820150506>3.0.co;2-3

Cited by 36 publications

(6 citation statements)

References 18 publications

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“…The pathogenesis of OME has been attributed to either organic obstruction or functional impairment of the tube. 24,25 Preirradiated NPC patients had less common organic obstruction due to nearly normal passive opening pressure but had impairment in active tubal opening. Prevalence of OME increased once the tumor extended to the parapharyngeal space.…”

Section: Otitis Media With Effusionmentioning

confidence: 99%

Irradiated ears in nasopharyngeal carcinoma survivors: A review

Young

2018

The Laryngoscope

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This article reviews the literature on otological complications in nasopharyngeal carcinoma (NPC) survivals after irradiation during the past three decades. Symptoms of the irradiated ears were assessed from the external ear canal, through the middle ear cavity including the Eustachian tube, and to the inner ear compartments. The development of radioimaging diagnostic techniques, the introduction from adjuvant chemotherapy to concurrent chemoradiotherapy, and the invention of radiotherapeutic equipment to intensity-modulated radiotherapy (IMRT) have increased the survival rate of NPC patients during the past 30 years. The prevalence of cochlear and vestibular deficits has decreased a lot, whereas middle ear complications (i.e., otitis media with effusion and radiation-induced otitis media) do not decline in NPC survivors even in the IMRT era, probably because the medial half of the Eustachian tube receives > 95% of the total dose despite 2DRT or IMRT. Laryngoscope, 2018.

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Section: Otitis Media With Effusionmentioning

confidence: 99%

Irradiated ears in nasopharyngeal carcinoma survivors: A review

Young

2018

The Laryngoscope

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“…Die Haufigkeit der Fernmetastasierung wurde von anderen Autoren unterschiedlich angegeben. Godtfredsen [138] beobachtete unter 118 Lymphoepitheliomen und Transitionalzellkarzinomen etwa 19% Fernmetastasen, Wang [425] bei 115 malignen Nasenrachentumoren (96 Karzinome) 59% und van Andel [417] bei 89 Karzinomen 49% Fernmetastasen. Diese stark differierenden Angaben kommen wahrscheinlich dadurch zustande, daB die Patienten in unterschiedlichen Stadien der Krankheit untersucht wurden.…”

Section: Fernmetastasenunclassified

“…Dann folgen mit 38% nasale, mit 35% otologische und mit 31 % ophthalmo-neurologische Symptome. Eine gleiche Reihenfolge der Symptomatik wurde auch in einer anderen Literaturzusammenstellung [341], die insgesamt1171 FaIle umfaBt, vorgefunden [33,138,148,283,313,340,343,425]. Nach dieser Statistik kamen Lymphknotenmetastasen in 47%, nasale Symptome in 34%, otologische Symptome in 33% und ophthalmoneurologische Symptome in 26,5% der FaIle vor.…”

Section: Symptomeunclassified

Klinik virusbedingter Tumoren

Sesterhenn

1983

Teil I: Referate

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“…Bezieht man die Titerh6he auf den histologischen Differenzierungsgrad unserer Nasopharynxkarzinome, so zeigt das lymphoepitheliale Karzinom um den Faktor 2-3 h6here Titer als das undifferenzierte oder gering differenzierte, nicht verhornende Plattenepithelkarzinom. Dies wiirde bedeuten, daB es sich beim lymphoepithelialen Karzinom um einen eigenstandigen Tumor handelt, entsprechend der klinischen Erfahrung, daB die lymphoepithelialen Karzinome besser auf eine Bestrahlung ansprechen als andere Karzinome und daB die Uberlebensrate dieser Patienten deutlich h6her ist (Wang et al 1962;von Ilberg et al 1976;D6hnert 1977).…”

Section: Antikorperspektren Bei Tumorpatientenunclassified

Virale Krankheiten im HNO-Bereich

Wilmes¹,

Deinhardt

1983

Teil I: Referate

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Viral infections cause many diseases in the mucous membranes, the upper respiratory and digestive tract, the salivary glands and the ear.Recent advances in the pathogenesis of viral diseases brought about an increasing interest of otolaryngologists.The general part of this paper presents the fundamental properties of viruses, their structure and replication, and the pathogenesis of the different forms of viral infections.The section of viral diagnosis describes laboratory methods and their limits as well as the clinical interpretation of viral tests.An overview of prophylaxis and therapy of viral infections is given.The specialized section of the paper describes viral infections important for the otorhinolaryngologist. It includes infections of the aero-digestive tract, the ear and the salivary glands.Because of its special importance, Epstein-Barr virus and its associated diseases, and hypotheses about the oncogenesis of EBV -correlated tumours are presented in detail.The topic of the third part is the actual knowledge about interferon and its antiviral and antitumour effects. The findings of important clinical studies are discussed.The last chapter concerns with virushepatitis.Zusammenfassung. Virale Infektionen sind die Ursache einer Vielzahl von Erkrankungen im Bereich der Schleimhiiute des oberen Respirations-und Digestionstraktes, der Speiche1driisen und des Ohres.Neue Erkenntnisse der letzten Jahre tiber die Pathogenese viraler Erkrankungen fiihren zum wachsenden Interesse des HNO-Facharztes an deren Diagnostik und Therapie.Der allgemeine Teil dieses Referates macht mit wichtigen virologischen Grundlagen vertraut:Es wird auf die Struktur und die Vermehrung der Viren eingegangen sowie

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Cancer of the nasopharynx. Its clinical and radiotherapeutic considerations

Cited by 36 publications

References 18 publications

Irradiated ears in nasopharyngeal carcinoma survivors: A review

Irradiated ears in nasopharyngeal carcinoma survivors: A review

Klinik virusbedingter Tumoren

Virale Krankheiten im HNO-Bereich

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