Cancer of the Small and Large Intestine

Brodsky, Edwin

doi:10.1002/9781119501237.ch142

Cited by 3 publications

(8 citation statements)

References 6 publications

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“…In terms of specific tumor types, lymphoma accounts for nearly 30% of all feline tumors, making it the most common cancer, located primarily in the gastrointestinal tract in most studies, and the number of cases is increasing [1][2][3]36,49,51]. Currently, the median age of onset is 10-12 years [24].…”

Section: Lymphoma In Cats and Dogsmentioning

confidence: 99%

The Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats

Breczko,

Bubak,

Miszczak

2024

Cancers

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Recent advancements have significantly enhanced our understanding of the crucial role animal microbiomes play in veterinary medicine. Their importance in the complex intestinal environment spans immune modulation, metabolic homeostasis, and the pathogenesis of chronic diseases. Dysbiosis, a microbial imbalance, can lead to a range of diseases affecting both individual organs and the entire organism. Microbial disruption triggers inflammatory responses in the intestinal mucosa and disturbs immune homeostasis, increasing susceptibility to toxins and their metabolites. These dynamics contribute to the development of intestinal lymphoma, necessitating rigorous investigation into the role of microbiota in tumorigenesis. The principles explored in this study extend beyond veterinary medicine to encompass broader human health concerns. There are remarkable parallels between the subtypes of lymphoproliferative disorders in animals and humans, particularly Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Understanding the etiology of a cancer of the lymphatic system formation is critical for developing both preventive strategies and therapeutic interventions, with the potential to significantly improve patient outcomes. The aim of this study is to discuss the optimal composition of the microbiome in dogs and cats and the potential alterations in the microbiota during the development of intestinal lesions, particularly intestinal lymphoma. Molecular and cellular analyses are also incorporated to detect inflammatory changes and carcinogenesis. A review of the literature on the connections between the gut microbiome and the development of lymphomas in dogs and cats is presented, along with potential diagnostic approaches for these cancers.

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Section: Lymphoma In Cats and Dogsmentioning

confidence: 99%

The Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats

Breczko,

Bubak,

Miszczak

2024

Cancers

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“…1 They comprise 8% of all neoplasms of this species, and their incidence increases in middle-aged dogs, ranging from 6 to 9 years. 1,2 Gastrointestinal stromal tumours (GIST) have been reported in humans, dogs, domestic cats and other species. [3][4][5][6] They are mesenchymal neoplasms believed to originate from multipotent stem cells that are phenotypically similar to interstitial cells of Cajal (pacemaker cells of the intestinal tract that regulate peristalsis).…”

Section: Introductionmentioning

confidence: 99%

“…13,14 The clinical behaviour of GIST is very broad, and the clinical signs include one or more of the following: anorexia, vomiting, diarrhoea, weight loss, melena and lethargy. 2 However, many patients are asymptomatic, mainly when the tumour is small or has extraluminal growth. In cases where the tumour is at a more advanced stage, abdominal pain, bleeding, abdominal distension, early satiety, fatigue and a palpable mass may occur.…”

Section: Introductionmentioning

confidence: 99%

“…Primary gastrointestinal tumours are rare in dogs and can have epithelial, mesenchymal, neuroendocrine or round cell origin 1 . They comprise 8% of all neoplasms of this species, and their incidence increases in middle‐aged dogs, ranging from 6 to 9 years 1,2 …”

Section: Introductionmentioning

confidence: 99%

“…The clinical behaviour of GIST is very broad, and the clinical signs include one or more of the following: anorexia, vomiting, diarrhoea, weight loss, melena and lethargy 2 . However, many patients are asymptomatic, mainly when the tumour is small or has extraluminal growth.…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal stromal tumour and its systemic effects in a dog

de Souza,

de Dória,

de Leme

et al. 2023

Vet Record Case Reports

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Gastrointestinal stromal tumours are mesenchymal‐origin tumours previously misclassified as leiomyosarcomas in dogs. They are uncommon in dogs; however, their prevalence may have been underestimated. The systemic effects of gastrointestinal stromal tumours in dogs need to be better understood. This case report describes the systemic complications and treatment of a dog with paraneoplastic hypoglycaemia and transient hyperglycaemia caused by gastrointestinal stromal tumours.

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Preventive Effects of Bovine Gallstone on Murine Colon Neoplasia: Room for Improvement?

Demirkan

Kavas²,

Bozkurt

et al. 2023

Journal of Research in Veterinary Medicine

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Bovine gallstone (BGS) has been suggested to be used in the treatment of many diseases including neoplastic maladies in traditional medicine. Thus, this study aimed at evaluating the possible protective effects of BGS in mice colon tumor model. In the experiment, 8 week-old 30 male BALB/c mice weighing 25-30 g were randomly allocated into control group (n=6), tumor group ((n=6; tumor induced by 1,2- dimethylhydrazine? [DMH]), BGS>DMH group (n=6; BGS given prior to DMH challenge), BGS//DMH group (n=6; simultaneous administration of BGS and DMH) and DMH>BGS group (n=6; tumor induced by DMH then BGS given). Colonic tumor was induced by weekly subcutaneous injection of DMH at a 20 mg/kg/mouse dose for consequetive 11 weeks. BGS preparations were given to mice cyclically. Atypical cryptic foci formation in the colon was examined by histopathological staining. The lowest rate of colon tumor was noted in BGS>DMH group where BGS was given prior to tumor challenge. In addition simultaneous administration of DMH and BGS to mice inhibited tumor formation and development more significantly than those in other groups (except for BGS>DMH group). It was concluded that BGS significantly prevented colonic tumor formation if given to subjects before or during tumor challenge however, therapeutic capacity of BGS was not promising in this study.

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Cancer of the Small and Large Intestine

Cited by 3 publications

References 6 publications

The Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats

The Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats

Gastrointestinal stromal tumour and its systemic effects in a dog

Preventive Effects of Bovine Gallstone on Murine Colon Neoplasia: Room for Improvement?

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