Cancer of the Thyroid

Chesky, V. E.; Hellwig, C. A.; McCUSKER, E. N.; Welch, J. W.

doi:10.1001/archsurg.1959.04320120098011

Cited by 5 publications

(4 citation statements)

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“…Table 6 is a summary of various authors’ findings (4, 18‐22) for the incidence of carcinoma in thyroid glands that were respectively uninodular, multinodular, or diffusely enlarged. Carcinoma was found most frequently in the solitary nodules, the incidence ranging from 8.5 to 63 per cent.…”

Section: Thyroid Carcinoma In Association With Other Thyroid Diseasesmentioning

confidence: 99%

“…Woolner et al (5) found hyperthyroidism in 25 (4.6 per cent) of 541 cases of carcinoma, but nodal metastases in only 2 of the 25 cases. Clark (23) observed thyroiditis in 18 per cent of 60 cases of carcinoma of the thyroid.…”

Section: Thyroid Carcinoma In Association With Other Thyroid Diseasesmentioning

confidence: 99%

“…In a study (23) of 193 routine autopsies, 21 cases of unsuspected carcinoma of the thyroid were found; in 69 of these 193 autopsies the correct diagnosis of thyroid carcinoma had been made during life (23). Mortensen et al (24) in 1000 consecutive routine autopsies found that: 1) one or more thyroid nodules were present in 50 per cent of the cases, 2) 12 per cent of these nodules were solitary, and 3) 21 per cent of the solitary nodules contained carcinoma.…”

Section: Unsuspected Thyroid Carcinomamentioning

confidence: 99%

“…Clark's explanation (23) for intraglandular spread is based on the presence of a rich network of intercommunicating lymph vessels which can transport tumor cells from one lobe to the other. The tumor cell travels through the interfollicular lymphatics to distant areas of the gland until it reaches the capsule which serves as a barrier to extraglandular spread.…”

Section: Multiple Foci and Intraglandular Spreadmentioning

confidence: 99%

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Carcinoma of the Thyroid in Patients Aged 50 or Older*

Hoffman

1974

J American Geriatrics Society

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At the Sinai Hospital of Baltimore, carcinoma of the thyroid was studied in 60 patients whose ages ranged from 50 to 79 years (Series AA). Data on the author's Series A (185 patients of various ages) and data from reports in the literature (children or adults of various ages) are used for comparison. Carcinoma of the thyroid is fairly common in the 50+ age group, constituting 32 per cent of the cases in patients of all ages (Series A). In the patients aged 50 or older (Series AA), the ratio of females to males was 5.7:1.0 versus 3.9:1.0 for patients of all ages. The thyroid carcinoma was multifocal in 18 per cent of the elderly patients. It was found incidentally upon physical examination in almost two‐thirds of the cases. Radioiodine tracing was of little help diagnostically. The best criterion for diagnosis is a high index of suspicion on the part of the physician. If thyroid nodules are treated aggressively, carcinoma can be diagnosed earlier. Often a preoperatively palpable nodule is not the one identified microscopically as containing carcinoma. Frozen‐section diagnosis can be misleading; in 46 per cent of Series AA, the frozen section was reported as benign whereas the permanent sections were reported as carcinoma. The treatment of choice is total thyroidectomy followed by radioiodine therapy if any foci of carcinoma are found by postoperative scanning. Prophylactic removal of lymph nodes is of no value. Thyroid substitution therapy should be started as soon as possible after operation. With use of the author's methods, postoperative tetany and vocal cord paralysis can be avoided. The mortality rate for thyroid carcinoma in the 60 patients of the 50+ age group was 25 per cent. Of the 15 deaths secondary to metastases, 7 were from solid or anaplastic, 5 from follicular, and 3 from papillary or mixed papillary carcinoma. Thus the papillary type is not always benign, as described by some authors. Thirty of the 60 patients were traceable five or more years after surgery. Of these, 10 had died from thyroid carcinoma, 1 had died from another cause, and 3 were alive but with metastases; however, 16 were alive and free of thyroid carcinoma.

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Section: Thyroid Carcinoma In Association With Other Thyroid Diseasesmentioning

confidence: 99%

Section: Thyroid Carcinoma In Association With Other Thyroid Diseasesmentioning

confidence: 99%

Section: Unsuspected Thyroid Carcinomamentioning

confidence: 99%

Section: Multiple Foci and Intraglandular Spreadmentioning

confidence: 99%

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Carcinoma of the Thyroid in Patients Aged 50 or Older*

Hoffman

1974

J American Geriatrics Society

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Anaplastic carcinoma of the thyroid with osteoclast-like giant cells

Esmaili

Hafez

Warner

1983

Cancer

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An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre-existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicular carcinoma with gradual transition to undifferentiated carcinoma. Pleomorphic spindle-shaped cells and giant cells were accompanied by numerous osteoclast-like multinucleated giant cells. Desmosomes and interdigitating cell surfaces were apparent in the differentiated as well as undifferentiated areas on electron microscopy. These findings support an epithelial rather than a mesenchymal origin for this neoplasm.

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Die Schilddrüse

Walthard¹

1969

Spezielle Pathologische Anatomie

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Cancer of the Thyroid

Cited by 5 publications

References 0 publications

Carcinoma of the Thyroid in Patients Aged 50 or Older*

Carcinoma of the Thyroid in Patients Aged 50 or Older*

Anaplastic carcinoma of the thyroid with osteoclast-like giant cells

Die Schilddrüse

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