Cancer of the thyroid associated with Hashimotoʼs disease

Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto’s thyroiditis: a stem cell hypothesis of papillary carcinoma oncogenesis

“…Various studies place the risk of developing PTC in patients with HT at 0 to 30%. [48][49][50][51][52][53][54][55][56] In the present study, 48.5% of HT cases were associated with SCNs, including squamoid nests, comparable to a previously reported 51% prevalence of SCNs in HT. 33 Of interest, in a series of mucoepidermoid carcinomas (linked etiologically to SCNs, see Discussion above), concurrent Hashimoto's or lymphocytic thyroiditis was found in every case.…”

“…• In contrast to p63 positivity in PTCs, p63-negative follicular epithelium in nodular goiter, follicular adenomas, and follicular carcinomas probably arise from p63-negative mature thyrocytes by unrelated mechanisms. • The existence of residual p63-positive pluripotent stem cells in the developed thyroid may be the biologic basis for the reported clinical predisposition to PTC in patients with HT: [48][49][50][51][52][53][54][55][56] Both disorders may be initiated by the same population of p63-positive pluripotent embryonal remnants.…”

Carcinoma papilífero da tireoide associado à tireoidite de Hashimoto: frequência e aspectos histopatológicos

“…Contudo, também há relato de casos de CP e TH associados à média de idade de 44 anos, sendo todos os casos em mulheres (4) , ou 39,1 anos, semelhante à verificada no nosso estudo, sendo a maioria do sexo feminino (12 mulheres e um homem) (7) . Quanto ao sexo dos pacientes, nosso estudo demonstrou predomínio de mulheres, não existindo diferença significativa em relação a esse aspecto, tal como referido em uma série de 13 pacientes com câncer da tireoide associado a TH (12 desses casos eram CPs e um carcinoma folicular), na qual também a multifocalidade estava presente em seis dos 13 casos (7) .…”

A Hashimoto-thyreoiditisben kialakuló papillaris pajzsmirigy-carcinoma klinikopatológiai jellegzetességei

“…Néhány korábbi kohorszvizsgálat úgy találta, hogy a PPC gyakrabban jelentkezik HT-s betegeknél, mint a HT-ben nem érintett betegek körében [9][10][11][12], azonban mások ezt vitathatónak tartották [13][14][15]. A két betegség közötti asszociációt modernebb szemléletű keresztmetszeti vizsgálatok egyértelműbben támasztják alá, ösz-szességében mára elfogadott tény a PPC és a HT összefüggése [16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”