Cancer of the thyroid gland in geriatric age: A single center retrospective study with a 10-year post-operative follow-up

Santangelo, Giuseppe; Giudice, S; Gallucci, F.; Parmeggiani, U; Falco, Massimo De

doi:10.1016/j.ijsu.2014.08.368

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…We found that the tumor size. TNM stage, tumor grade and age are independent risk factors for cancer-specific survival, consistent with most research results [ 31 – 34 ].…”

Section: Discussionsupporting

confidence: 91%

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Development and validation of a nomogram to predict cancer-specific survival in elderly patients with papillary thyroid carcinoma: a population-based study

et al. 2022

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Objective Thyroid carcinoma (TC) is the most common endocrine tumor in the human body. Papillary thyroid carcinoma (PTC) accounts for more than 80% of thyroid cancers. Accurate prediction of elderly PTC can help reduce the mortality of patients. We aimed to construct a nomogram predicting cancer-specific survival (CSS) in elderly patients with PTC. Methods Patient information was downloaded from the Surveillance, Epidemiology, and End Results (SEER) program. Univariate and multivariate Cox regression models were used to screen the independent risk factors for patients with PTC. The nomogram of elderly patients with PTC was constructed based on the multivariate Cox regression model. We used the concordance index (C-index), the area under the receiver operating characteristic curve (AUC) and the calibration curve to test the accuracy and discrimination of the prediction model. Decision curve analysis (DCA) was used to test the clinical value of the model. Results A total of 14,138 elderly patients with PTC were included in this study. Patients from 2004 to 2015 were randomly divided into a training set (N = 7379) and a validation set (N = 3141), and data from 2016 to 2018 were divided into an external validation set (N = 3618). Proportional sub-distribution hazard model showed that age, sex, tumor size, histological grade, TNM stage, surgery and chemotherapy were independent risk factors for prognosis. In the training set, validation set and external validation set, the C-index was 0.87(95%CI: 0.852–0.888), 0.891(95%CI: 0.866–0.916) and 0.931(95%CI:0.894–0.968), respectively, indicating that the nomogram had good discrimination. Calibration curves and AUC suggest that the prediction model has good discrimination and accuracy. Conclusions We constructed a new nomogram to predict CSS in elderly patients with PTC. Internal cross-validation and external validation indicate that the model has good discrimination and accuracy. The predictive model can help doctors and patients make clinical decisions.

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“…We found that the tumor size. TNM stage, tumor grade and age are independent risk factors for cancer-specific survival, consistent with most research results [ 31 – 34 ].…”

Section: Discussionsupporting

confidence: 91%

“…We found that the tumor size. TNM stage, tumor grade and age are independent risk factors for cancer-specific survival, consistent with most research results[31][32][33][34].Age is associated with the prognosis of most malignancies, and thyroid cancer is only cancer in which age…”

supporting

confidence: 89%

Development and validation of a nomogram to predict cancer-specific survival in elderly patients with papillary thyroid carcinoma: a population-based study

et al. 2022

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“…18,20 Although some studies reported higher frequency of MTC in patients older than 75 years others reported no difference. 12,[20][21][22][23] Likely, authors did not find any difference in MTC between geriatric and nongeriatric patients in this study.…”

Section: Discussioncontrasting

confidence: 43%

“…17 Although some studies do not show differences prevalence of well-differentiated histotypes in their ages, PTC and FTC showed others it has been reported that PTC is less common in these patients. [17][18][19] In this study, PTC, the most common type of thyroid cancer in both groups at the same time, is less noticeable in geriatric than in non-geriatric patients. Authors could not find any difference in derivative distribution in geriatric and non-geriatric patients.…”

Section: Discussionmentioning

confidence: 98%

Thyroid cancer surgery in the elderly: a comparative study of 1176 patients

Parlak

Dellal

Ulusoy³

et al. 2018

Int Surg J

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Background: The aim of this study is to compare the results of patients who were treated with two groups (under 65 years and over 65 years) of thyroid cancer.Methods: A retrospective review of 1176 patients undergoing thyroid cancer surgery between January 2007 and December 2016 was performed. Patients were grouped as ≥65 (geriatric group) and <65 years (non-geriatric group).Results: A total of 139 patients (11.8%) were over 65 years of age and 1037 patients (88.2%) were under 65 years of age. There were 104 female (74.8%) and 35 (25.2%) male patients in the geriatric group. In the non-geriatric group, 917 (78%) patients were female and 259 (22%) were male (p = 0.39). FNAB showed a significant increase in malignant potential in the elderly (p = 0.005). In our series, malignant differences between geriatric and non-geriatric groups are less pronounced among thyroid carcinomas other than capsular invasion. Although there was no significant difference in histopathologic examination, malignant cytology was higher in the elderly patients. There was no significant difference between the young and elderly patients in terms of complication.Conclusions: In this study, papillary Thyroid Ca (PTC) was found to be the most common type of cancer and we could not find any difference in cancer type distribution in geriatric and non-geriatric patients. Total/near total thyroidectomy in experienced hands is safe for elderly patients. There is no difference in terms of complication.

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Thyroid and Parathyroid Diseases in Elderly Patients

Canonico

Falco

Santangelo

2017

Surgical Management of Elderly Patients

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Cancer of the thyroid gland in geriatric age: A single center retrospective study with a 10-year post-operative follow-up

Abstract: It would be useful to undertake randomized prospective studies on a large cohort of patients to determine the most effective therapy for geriatric patients suffering from thyroid carcinoma.

Cited by 8 publications

References 31 publications

Development and validation of a nomogram to predict cancer-specific survival in elderly patients with papillary thyroid carcinoma: a population-based study

Development and validation of a nomogram to predict cancer-specific survival in elderly patients with papillary thyroid carcinoma: a population-based study

Thyroid cancer surgery in the elderly: a comparative study of 1176 patients

Thyroid and Parathyroid Diseases in Elderly Patients

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